Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Christopher K. Macgowan"'
Autor:
Jack R. T. Darby, Dimitra Flouri, Steven K. S. Cho, Georgia K. Williams, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Anna L. David, Christopher K. Macgowan, Mike Seed, Andrew Melbourne, Janna L. Morrison
Publikováno v:
Experimental Physiology, Vol 109, Iss 6, Pp 980-991 (2024)
Abstract Increasing placental perfusion (PP) could improve outcomes of growth‐restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)‐5 inhibitors, which induce vasodilatation of vascular beds. We used a combination o
Externí odkaz:
https://doaj.org/article/b70c5383fcda4f8096488728f82dba8b
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Placental function plays a crucial role in fetal development, as it serves as the primary interface for delivery of nutrients and oxygen from the mother to fetus. Magnetic resonance imaging (MRI) has significantly improved our ability to visualize an
Externí odkaz:
https://doaj.org/article/f9af9da7265e4f549821a7a5cb8973c0
Autor:
Jack R. T. Darby, Brahmdeep S. Saini, Stacey L. Holman, Sarah J. Hammond, Sunthara Rajan Perumal, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe fetal haemodynamic response to acute episodes of hypoxaemia are well characterised. However, how these responses change when the hypoxaemia becomes more chronic in nature such as that associated with fetal growth restriction (FGR), is
Externí odkaz:
https://doaj.org/article/3e5e45377bfd4531afb0d08f7547afd1
Autor:
Jenna Hanrahan, Katherine L. Steeves, Drew P. Locke, Thomas M. O’Brien, Alexandre S. Maekawa, Roshanak Amiri, Christopher K. Macgowan, Ahmet A. Baschat, John C. Kingdom, André J. Simpson, Myrna J. Simpson, John G. Sled, Karl J. Jobst, Lindsay S. Cahill
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract While microplastics have been recently detected in human blood and the placenta, their impact on human health is not well understood. Using a mouse model of environmental exposure during pregnancy, our group has previously reported that expo
Externí odkaz:
https://doaj.org/article/0a17cb70679b41b08cf3a81a4f2df2f1
Autor:
Jack R. T. Darby, Georgia K. Williams, Steven K. S. Cho, Ashley S. Meakin, Stacey L. Holman, Megan Quinn, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Publikováno v:
Physiological Reports, Vol 11, Iss 12, Pp n/a-n/a (2023)
Abstract Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratro
Externí odkaz:
https://doaj.org/article/97005ba9184b4e3eb4484b0a9f643b81
Autor:
Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility
Externí odkaz:
https://doaj.org/article/41d944f0f2624c8aa1881cb341321ea5
Autor:
Dakshita Jagota, Hannah George, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Lena Serghides, W. Tony Parks, Ahmet A. Baschat, Christopher K. Macgowan, John G. Sled, John C. Kingdom, Lindsay S. Cahill
Publikováno v:
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-6 (2021)
Abstract Background Fetal sex is known to affect pregnancy outcomes. In current clinical practice, monitoring of fetal well-being is based on Doppler ultrasound measurements of major placental and fetal vessels. The objective of this study was to inv
Externí odkaz:
https://doaj.org/article/535d116cfd5c4d909e6f5d302c959268
Autor:
Leah Paranavitana, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Lena Serghides, W. Tony Parks, Ahmet A. Baschat, Christopher K. Macgowan, John G. Sled, John C. Kingdom, Lindsay S. Cahill
Publikováno v:
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-6 (2021)
Abstract Background There is growing evidence of sex differences in placental vascular development. The objective of this study was to investigate the effect of fetal sex on uterine artery pulsatility index (PI) throughout gestation in a cohort of no
Externí odkaz:
https://doaj.org/article/b616dab2eeaa456381d8998dfa1d4712
Autor:
Daniel Salehi, Liqun Sun, Katarina Steding-Ehrenborg, Sebastian Bidhult, Fabian Kording, Christian Ruprecht, Christopher K. Macgowan, Michael Seed, Anthony H. Aletras, Håkan Arheden, Erik Hedström
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-15 (2019)
Abstract Introduction Fetal cardiovascular magnetic resonance (CMR) imaging is used clinically and for research, but has been previously limited due to lack of direct gating methods. A CMR-compatible Doppler ultrasound (DUS) gating device has resolve
Externí odkaz:
https://doaj.org/article/c3ba589089884fd2b5b4c9bac2563fcc
Autor:
Eric M. Schrauben, Jack R. T. Darby, Mary J. Berry, Brahmdeep S. Saini, Megan Quinn, Stacey L. Holman, Emma L. Bradshaw, Mitchell C. Lock, Sunthara R. Perumal, Steven K. S. Cho, Tanroop Aujla, Mike Seed, Christopher K. Macgowan, Janna L. Morrison
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract The ductus arteriosus (DA) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes. The thorough and explicit measurement and visualization of the right and lef
Externí odkaz:
https://doaj.org/article/dd843328b05b4f098c3539acbd75d33e