Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christopher K Murphy"'
Autor:
Callum AH Docherty, Anuruddika J Fernando, Sarah Rosli, Maggie Lam, Roland E Dolle, Manuel A Navia, Ronald Farquhar, Danny La France, Michelle D Tate, Christopher K Murphy, Adriano G Rossi, Ashley Mansell
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Objectives Inflammasomes induce maturation of the inflammatory cytokines IL‐1β and IL‐18, whose activity is associated with the pathophysiology of a wide range of infectious and inflammatory diseases. As validated therapeutic targets fo
Externí odkaz:
https://doaj.org/article/f402fa42dc57419ea86338a42ffe4836
Publikováno v:
The Journal of Antibiotics. 60:572-576
We describe novel rifamycins that have improved activity, compared with rifampin, against clinical isolates of staphylococci and streptococci, with MIC(90)s of 0.008 and 0.0005 microg/ml, respectively. This enhanced antibacterial activity, along with
Autor:
Chester W. Price, Hélène Cérémonie, Nancy Su, Philip Youngman, Christopher K. Murphy, Paul Fawcett
Publikováno v:
Molecular Microbiology. 41:757-774
Bacteria respond to diverse growth-limiting stresses by producing a large set of general stress proteins. In Bacillus subtilis and related Gram-positive pathogens, this response is governed by the sigma(B) transcription factor. To establish the range
Publikováno v:
Journal of Biological Chemistry. 275:40128-40133
Enoyl-[acyl-carrier-protein] (ACP) reductase is a key enzyme in type II fatty-acid synthases that catalyzes the last step in each elongation cycle. The FabI component of Bacillus subtilis (bsFabI) was identified in the genomic data base by homology t
Autor:
Patrick J. Carroll, Gajendran Sundarababu, Franklin A. Davis, ‡ and Bang-Chi Chen, Ping Zhou, Christopher K. Murphy, Hongyan Qi, Robert M. Przeslawski, Wei Han
Publikováno v:
The Journal of Organic Chemistry. 63:2273-2280
The asymmetric “electrophilic” fluorination of tertiary enolates by nonracemic N-fluoro-2,10-camphorsultams 3 affords quaternary α-fluoro carbonyl compounds in modest yield and ee. The highest asymmetric induction was observed for the fluorinati
Publikováno v:
The Journal of Organic Chemistry. 60:4730-4737
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 60:277-283
Autor:
Aurora S. Pepito, Robert P. Discordia, Donald C. Dittmer, Yanzhi Zhang, Yuesheng Wang, Archana Kumar, Christopher K. Murphy
Publikováno v:
The Journal of Organic Chemistry. 58:718-731
Good yields of enantiomeric allylic alcohols can be obtained in high enantiomeric excess (ee) by combining the Sharpless-Katsuli asymmetric epoxidation process (SAE) with tellurium chemistry. The advantages of the tellurium process are as follows: (1
Autor:
Donald C. Dittmer, Yanzhi Zhang, Christopher K. Murphy, Archana Kumar, A. S. Pepito, Robert P. Discordia, Y. Wang
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 22