Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Christopher K Barlow"'
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Publikováno v:
eLife, Vol 12 (2023)
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://doaj.org/article/4e8722171a41474ebb674b4e800efafa
Autor:
Kang-Yu Peng, Christopher K Barlow, Helene Kammoun, Natalie A Mellett, Jacquelyn M Weir, Andrew J Murphy, Mark A Febbraio, Peter J Meikle
Publikováno v:
Metabolites, Vol 11, Iss 3, p 188 (2021)
There is a strong association between hepatocyte phospholipid homeostasis and non-alcoholic fatty liver disease (NAFLD). The phosphatidylcholine to phosphatidylethanolamine ratio (PC/PE) often draws special attention as genetic and dietary disruption
Externí odkaz:
https://doaj.org/article/5ce77a6cc4864340ad96bdf2249349c3
Autor:
Milena M. Awad, Chathura D. Suraweera, Callum J. Vidor, Auberon Y. Ye-Lin, Galain C. Williams, Steven J. Mileto, Christopher K. Barlow, Sheena McGowan, Dena Lyras
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion.
Externí odkaz:
https://doaj.org/article/4a446196e3d143f6a77c4fab0b7aaa47
Autor:
Felipe Martelli, Annelise Quig, Sarah Mele, Jiayi Lin, Tahlia L. Fulton, Mia Wansbrough, Christopher K. Barlow, Ralf B. Schittenhelm, Travis K. Johnson, Matthew D. W. Piper
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and s
Externí odkaz:
https://doaj.org/article/1402184d5678404da39f83a9a59792eb
Autor:
Peter J Meikle, Piyushkumar A Mundra, Gerard Wong, Khairunnessa Rahman, Kevin Huynh, Christopher K Barlow, Alastair M P Duly, Paul S Haber, John B Whitfield, Devanshi Seth
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130346 (2015)
Liver disease is the greatest cause of death related to alcohol and a major public health problem. While excessive alcohol intake results in hepatosteatosis in most individuals, this can progress in some to more severe forms of liver disease includin
Externí odkaz:
https://doaj.org/article/5b0154d2f2b647658d03e4da340b4482
Autor:
Mei-Ling Han, Yasser Alsaadi, Jinxin Zhao, Yan Zhu, Jing Lu, Xukai Jiang, Wendong Ma, Nitin A. Patil, Rhys A. Dunstan, Anton P. Le Brun, Hasini Wickremasinghe, Xiaohan Hu, Yimin Wu, Heidi H. Yu, Jiping Wang, Christopher K. Barlow, Phillip J. Bergen, Hsin-Hui Shen, Trevor Lithgow, Darren J. Creek, Tony Velkov, Jian Li
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114410- (2024)
Summary: Polymyxins are often the only effective antibiotics against the “Critical” pathogen Acinetobacter baumannii. Worryingly, highly polymyxin-resistant A. baumannii displaying dependence on polymyxins has emerged in the clinic, leading to di
Externí odkaz:
https://doaj.org/article/ecbb468e0c314b388fb60a1edfa978ee
Autor:
Peter J Meikle, Gerard Wong, Christopher K Barlow, Jacquelyn M Weir, Melissa A Greeve, Gemma L MacIntosh, Laura Almasy, Anthony G Comuzzie, Michael C Mahaney, Adam Kowalczyk, Izhac Haviv, Narelle Grantham, Dianna J Magliano, Jeremy B M Jowett, Paul Zimmet, Joanne E Curran, John Blangero, Jonathan Shaw
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74341 (2013)
The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids might improve the understa
Externí odkaz:
https://doaj.org/article/856340692ae64f699386a345f52d7cc9
Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes.
Autor:
Gerard Wong, Christopher K Barlow, Jacquelyn M Weir, Jeremy B M Jowett, Dianna J Magliano, Paul Zimmet, Jonathan Shaw, Peter J Meikle
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76577 (2013)
A significant proportion of individuals with diabetes or impaired glucose tolerance have fasting plasma glucose less than 6.1 mmol/L and so are not identified with fasting plasma glucose measurements. In this study, we sought to evaluate the utility
Externí odkaz:
https://doaj.org/article/ed1b6a9ef553478aac7a445bb7385c85
Autor:
Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K. Barlow, Jefferson Paril, Ralf B. Schittenhelm, John Christodoulou, Hugo J. Bellen, Matthew D.W. Piper, Travis K. Johnson
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113861- (2024)
Summary: Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored becaus
Externí odkaz:
https://doaj.org/article/37055522b2c8443f94ea3b03560bb55f
Autor:
Mei-Ling Han, Sue C. Nang, Yu-Wei Lin, Yan Zhu, Heidi H. Yu, Hasini Wickremasinghe, Christopher K. Barlow, Darren J. Creek, Simon Crawford, Gauri Rao, Chongshan Dai, Jeremy J. Barr, Kim Chan, Robert Turner Schooley, Tony Velkov, Jian Li
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 485-495 (2022)
Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy is a promising alternative. However, phage monotherapy often rapidly causes resistance and few studies have examined antibiotic-phage co
Externí odkaz:
https://doaj.org/article/2a60c041def3434ca1a2990b05797555