Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christopher John Markworth"'
Autor:
Bruce M. Bechle, Stephen Martin Denton, Sebastien Galan, David James Rawson, Marcel J. de Groot, Brian E. Marron, Matthew S Johnson, Jo Hannam, Shoko Nakagawa, Dave Batchelor, Nigel Alan Swain, Steven M Reister, David Ellis, Mark L. Chapman, David Printzenhoff, Sarah J Ransley, Beaudoin Serge, David S. Millan, Christopher W. West, Kenneth John Butcher, R. Ian Storer, Stephen M Gaulier, Stupple Paul Anthony, Andrew Pike, Alan Daniel Brown, Christopher John Markworth, Bruce Brown, Zhixin Lin, Sasaki Kosuke, Paul A. Bradley, Ian Gurrell, Richard P. Butt, Mel Glossop, Ben S. Greener
Publikováno v:
Journal of medicinal chemistry. 60(16)
A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.7 inhibitors is described. Optimization of early lead matter focused on removal of structural alerts, improving metabolic stability and reducing cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78a3f0b6803242d1ea5f4b0b677ac41
https://pubmed.ncbi.nlm.nih.gov/28682065
https://pubmed.ncbi.nlm.nih.gov/28682065
Autor:
Hanson Gunnar J, Philip F. Hughes, Barta Thomas E, Amy F. Barabasz, Briana Foley, James Marvin Veal, Jeffrey M. Partridge, Christopher John Markworth, Andy J. Ommen, Melanie Silinski, Steven E. Hall, John W. Rice, Paul M. Steed, Emilie D. Smith, Patrick Fadden, Kenneth He Huang, Wei Ma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2550-2554
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by compound 15 (SNX-683
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7762235091c8d574857ff8ee4a9462
https://doi.org/10.1016/j.bmcl.2012.01.137
https://doi.org/10.1016/j.bmcl.2012.01.137
Autor:
Jeron Eaves, Meredith Lewis, Steven E. Hall, Amy F. Barabasz, Mei Hu, Andy J. Ommen, James Marvin Veal, Barta Thomas E, James C. Otto, Matthew Jenks, Bert Pronk, Jeffrey M. Partridge, John W. Rice, Melanie Silinski, Katleen Verleysen, Lindsay Hinkley, Jon-Paul Strachan, Briana Foley, Angela R. Woodward, Geng Lifeng, Anisa Scott, Emilie D. Smith, Wei Ma, Paul M. Steed, Tiffany Freed, Laura G. Dubois, W. Stephen Mccall, Hanson Gunnar J, Philip F. Hughes, Patrick Fadden, Kenneth He Huang, Christopher John Markworth
Publikováno v:
Journal of medicinal chemistry. 52(14)
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library. These indol-4-one and indazol-4-one derived 2-aminobenzamides showed strong binding affinity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf784b70aab9057c00338842d52013b
https://pubmed.ncbi.nlm.nih.gov/19552433
https://pubmed.ncbi.nlm.nih.gov/19552433