Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher John Davis"'
Autor:
Alasdair I. McKay, Michael C. Willis, Christopher John Davis, Antoine de Gombert, Katherine M Wheelhouse
Publikováno v:
Journal of the American Chemical Society
Pyridine and related heterocyclic sulfinates have recently emerged as effective nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with (hetero)aryl halides. These sulfinate reagents are straightforward to prepare, stable
Autor:
Chau Mak, Luca Settimo, Guy Brenchley, Francoise Pierard, Andrew Miller, Dean Boyall, Philip N. Collier, Adam Tanner, Heather Twin, Clare M. Bolton, Peter Chiu, Juan-Miguel Jimenez, Shazia Keily, Elisabeth Doyle, Adam P. Curnock, Ronald Knegtel, Christopher John Davis
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKCθ plays an important role in T cell biology and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were designed and synthesized starting from a HTS hit compound. Cell activit
Autor:
Somhairle Maccormick, Steven Durrant, Anisa Nizarali Virani, Christopher John Davis, Steve Young, Golec Julian M C, Storck Pierre Henri, Philip Michael Reaper, David Kay, John Pollard, Michael O'donnell, Heather Twin, Jean-Damien Charrier, Peter Littlewood, Matthew R. Griffiths, Joanne Pinder, Ronald Knegtel
Publikováno v:
Journal of medicinal chemistry. 62(11)
The DNA damage response (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of radiotherapy and DNA-damaging chemotherapy, commonly used treatment modalities in cancer. Two related kinases, ataxia telangiectasia m
Autor:
Jørgen Villadsen, Christopher John Davis, John Bruntse Larsen, Andrea Burattin, Rasmus Hjardem-Hansen
Publikováno v:
Business Process Management Workshops ISBN: 9783030374525
Business Process Management Workshops
Business Process Management Workshops
Agent-based simulation is a method for simulating complex systems by breaking them down into autonomous interacting agents. However, to create an agent-based simulation for a real-world environment it is necessary to carefully design the agents. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80683af229ddcd7ba6a0ff4bdc012c4
https://doi.org/10.1007/978-3-030-37453-2_46
https://doi.org/10.1007/978-3-030-37453-2_46
Autor:
Christopher John Davis
Publikováno v:
Tenso. 30:2-24
Autor:
Damien Fraysse, Peter Chiu, Philip N. Collier, Heather Twin, Luca Settimo, Francoise Pierard, Dean Boyall, Shazia Keily, Claire M. Bolton, Christopher John Davis, Guy Brenchley, Adam P. Curnock, Jaclyn Henderson, Adam Tanner, Juan-Miguel Jimenez, Andrew Miller, Stephen Clinton Young
Publikováno v:
Journal of medicinal chemistry. 56(5)
Protein kinase C θ (PKCθ) has a central role in T cell activation and survival; however, the dependency of T cell responses to the inhibition of this enzyme appears to be dictated by the nature of the antigen and by the inflammatory environment. St
Autor:
Ronald Knegtel, Ian Ager, Luca Settimo, Stephen Clinton Young, Dean Boyall, Richele K Rasmussen, Claire M. Bolton, Peter Chiu, Adam P. Curnock, Christopher John Davis, Adam Tanner, Juan-Miguel Jimenez, Damien Fraysse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
The identification of a novel series of PKCθ inhibitors and subsequent optimization using docking based on a crystal structure of PKCθ is described. SAR was rapidly generated around an amino pyridine-ketone hit; (6-aminopyridin-2-yl)(2-aminopyridin
Publikováno v:
Synlett. 2002:1874-1876
The naturally occurring benzoquinones primin 1 and pallasone B 2 were synthesised by a simple protocol involving microwave accelerated Claisen rearrangement of allyl ethers 4, followed by hydrogenation of the side chain alkene, and oxidation to the q
Publikováno v:
ChemInform. 36