Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher John Brown"'
Autor:
Anja Charlotte Lundgren Mortensen, Diana Spiegelberg, Christopher John Brown, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The tumor suppressor p53 is a key mediator of cellular stress and DNA damage response cascades and is activated after exposure to ionizing radiation. Amplifying wild-type p53 expression by targeting negative regulators such as MDM2 in combination wit
Externí odkaz:
https://doaj.org/article/625d8ae824cf4fb8841b5f0c06ec12c1
Autor:
Wei Mei Guo, Kiat Whye Kong, Christopher John Brown, Soo Tng Quah, Hui Ling Yeo, Shawn Hoon, Yiqi Seow
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Development of DNA aptamer screens that are both simple and informative can increase the success rate of DNA aptamer selection and induce greater adoption. High eIF4e levels contribute to malignancies, thus eIF4e presents itself as a valuable target
Externí odkaz:
https://doaj.org/article/ab266facd68b4c91ac904f9c7717649b
Autor:
Michael Prime, Samantha Green, Celia Dominguez, Edith Monteagudo, Malcolm Taylor, Akihiro Takano, Longbin Liu, Adrian Kotey, Wayne Thomas, Zhisheng Jia, Anthony P Dickie, Catherine Greenaway, Samuel Coe, Miklós Tóth, John Wityak, Vinod Khetarpal, Sergio Menta, Simone Esposito, Katarina Vanräs, Andreas Ebneth, John E. Mangette, Ian Wigginton, Todd Herbst, Peter Johnson, Sabine Schaertl, Vladimir Stepanov, Jonathan Bard, Sebastien Galan, Elise Gadouleau, Randall Davis, Christopher John Brown, Frank Herrmann, Richard W Marston, Darshan Gunvant Vaidya, Laura Orsatti, Xuemei Chen, Martina Nibbio, Manuela Heßmann, Joanne Sproston, Matthew R Mills, Ignacio Munoz-Sanjuan, Daniel Clark-Frew, Derek Alexander Weddell, Ladislav Mrzljak, Christoph Scheich, Xinjie Gai, Christer Halldin, Sangram Nag, Lee Matthew, Patricia Miranda-Azpiazu, Paul Giles, Thomas Krulle, Alexander Kiselyov, Marie Svedberg, Sarah Hayes
Publikováno v:
Journal of medicinal chemistry. 63(15)
Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington's disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bbb7331f2e0517d6d294883abdcc6f
https://pubmed.ncbi.nlm.nih.gov/32662649
https://pubmed.ncbi.nlm.nih.gov/32662649
Autor:
Leticia Toledo-Sherman, Catherine M. O'Connell, Christopher John Yarnold, Michael Prime, Suganathan Selvaratnam, Ignacio Munoz-Sanjuan, Ladislav Mrzljak, Arash Rassoulpour, Kimberly L Matthews, Patricia Wheelan, Laura Reed, Wolfgang Reindl, Alan Beresford, Estelle Hamelin-Flegg, Derek Alexander Weddell, William L. Mitchell, Dawn Yates, Maria Beconi, Weslyn Ward Friley, Christopher John Brown, Christin Winkler, Stephen Martin Courtney, Valerie Kempf, John Wityak, Naomi Went, Celia Dominguez, Isabell Cardaun, Kendall D. Powell, Ulrike Dijkman, Peter Johnson, Frederick Arthur Brookfield, Dirk Winkler, De Aguiar Pena Paula C, Kathy Lyons
Publikováno v:
Journal of medicinal chemistry. 58(3)
We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699f24106f0a18d2d3d4ac5e1d3ff8ca
https://pubmed.ncbi.nlm.nih.gov/25590515
https://pubmed.ncbi.nlm.nih.gov/25590515
Autor:
Christopher John Brown, Lee Hui Jun, Deepa Srinivasan, David P. Lane, David Coomber, Chandra S. Verma
Publikováno v:
Cell Cycle. 7:608-610
Florescence anisotropy measurements using FAM-labelled p53 peptides showed that the binding of the peptides to MDM2 was dependant upon the phosphorylation of p53 at Thr18 and that this binding was modulated by the electrostatic properties of MDM2. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed92e9389684f40ea945ff4d4ec5a50
https://doi.org/10.4161/cc.7.5.5488
https://doi.org/10.4161/cc.7.5.5488
Publikováno v:
Day 1 Mon, September 30, 2013.
Managed Pressure Drilling (MPD) has been used around the world to help drill wells where there is a tight mud weight (MW) window, due to the ability of the technology to more accurately control annular bottom hole pressure (BHP) while drilling, tripp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f704f332d6986fdb3edeac46aa98b29
https://doi.org/10.2118/166170-ms
https://doi.org/10.2118/166170-ms
Publikováno v:
Discovery medicine. 12(63)
A common step in human cancer is the inactivation of the p53 tumor suppressor pathway. This occurs either by mutations in the coding region of the p53 gene itself, or equally commonly, by inactivation of pathways that are required for p53 to exert it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50302161e29f26f16f40d100fac60059
https://pubmed.ncbi.nlm.nih.gov/21878188
https://pubmed.ncbi.nlm.nih.gov/21878188