Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christopher J. Wraight"'
Autor:
Susan M. Freier, Lynne M. Atley, Michael E. Cox, Christopher J. Wraight, Martin E. Gleave, Eigan Peralta, Junya Furukawa, Brett P. Monia
Publikováno v:
The Prostate. 70:206-218
OBJECTIVE Altered expression of insulin-like growth factor receptor (IGF-1R) is associated with castrate-resistant prostate cancer (CRPC) progression. We hypothesize that increased expression and/or responsiveness of IGF-IR may promote disease progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45de944a96935672facd36d0d8f7f68a
https://doi.org/10.1002/pros.21054
https://doi.org/10.1002/pros.21054
Autor:
Christopher J. Wraight, George A. Werther, Susan P. Thumiger, Timothy E. Adams, Stephanie R. Edmondson
Publikováno v:
Growth Factors. 23:151-159
The insulin-like growth factor receptor (IGF-IR) is critical in epidermal development and IGF binding protein-3 (IGFBP-3), a modulator of cellular activity with or without IGF-dependence, co-localises with epidermal IGF-IRs. We have investigated whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961ab3a64489b183fc42fcaee927f91f
https://doi.org/10.1080/08977190500153680
https://doi.org/10.1080/08977190500153680
Publikováno v:
Expert Opinion on Biological Therapy. 4:75-81
Antisense oligonucleotides are emerging as an exciting therapeutic strategy for treating skin diseases such as psoriasis. Potential antisense targets are proteins upregulated in psoriatic skin, in particular those associated with inflammation (interc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d19e4cb633649db978a447adb04afb
https://doi.org/10.1517/14712598.4.1.75
https://doi.org/10.1517/14712598.4.1.75
Publikováno v:
Endocrine Reviews. 24:737-764
GH and IGF-I and -II were first identified by their endocrine activity. Specifically, IGF-I was found to mediate the linear growth-promoting actions of GH. It is now evident that these two growth factor systems also exert widespread activity througho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba40c38d86369b7669a219b469105ae
https://doi.org/10.1210/er.2002-0021
https://doi.org/10.1210/er.2002-0021
Autor:
Andrew C. Gray, Rhys Fogarty, Paul J. White, Christopher J. Wraight, Rodney Sinclair, George A. Werther, Susan P. Thumiger
Publikováno v:
Journal of Investigative Dermatology. 118(6):1003-1007
We have previously shown that antisense oligonucleotides effectively reduced insulin-like growth factor I receptor expression in human psoriatic skin grafted on to nude mice when injected intradermally. We therefore investigated the penetration of C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1a98c84899dcff5152a0ca3f71101f
Publikováno v:
Journal of Investigative Dermatology. 116:491-497
The insulin-like growth factor (IGF) system is essential for epidermal homeostasis. Insulin-like growth factor binding protein 3 (IGFBP-3), a modulator of IGF action that also exhibits IGF-independent activity, is localized to selected keratinocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133b15e363f54b5cc4968a8a039fe006
https://doi.org/10.1046/j.0022-202x.2001.temp.doc.x
https://doi.org/10.1046/j.0022-202x.2001.temp.doc.x
Autor:
Paul J. White, Stephanie R. Edmondson, Christopher J. Wraight, Sandra C. McKean, Daryl J. Venables, Ingrid J. Liepe, George A. Werther, Rhys Fogarty
Publikováno v:
Nature Biotechnology. 18:521-526
Epidermal hyperplasia is a key feature of the common skin disorder psoriasis. Stimulation of epidermal keratinocytes by insulin-like growth factor I (IGF-I) is essential for cell division, and increased sensitivity to IGF-I may occur in psoriasis. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dddb4b936915483d3adc736edc8d16
https://doi.org/10.1038/75382
https://doi.org/10.1038/75382
Autor:
Paul J. White, Christopher J. Wraight, Ingrid J. Liepe, Rhys Fogarty, George A. Werther, Peter M Delaney
Publikováno v:
Journal of Investigative Dermatology. 112(6):887-892
Anti-sense oligonucleotide uptake by keratinocytes in human skin grafts on athymic mice was examined using live confocal microscopy. Fluorescein isothiocyanate-labeled 15-mer C-5 propyne modified phosphorothioate anti-sense oligonucleotide (10-50 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35566043e8bb3403ef27c9273945939f
Autor:
Rhys Fogarty, George A. Werther, Daryl J. Venables, Paul J. White, Sandra C. McKean, Christopher J. Wraight
Publikováno v:
Journal of Investigative Dermatology. 112:699-705
The success of anti-sense strategies has been limited, at least in part, by the poor uptake of these agents into the target cells. In keratinocytes, there is conflicting evidence as to the amount and location of oligonucleotide uptake into these cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e595e752e8f7edf831afb706d84d1b
https://doi.org/10.1046/j.1523-1747.1999.00578.x
https://doi.org/10.1046/j.1523-1747.1999.00578.x
Autor:
George A. Werther, Andrew C. McFarlane, Stephanie R. Edmondson, Vincenzo C. Russo, Christopher J. Wraight
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:1638-1644
Melanocytes, highly differentiated neural crest-derived cells, are located in the basal layer of the epidermis, where they play a role in protecting against UV damage in the skin. Previous studies suggest that both growth hormone (GH) and the insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dba279b01c64570d55bdb243b3b3fdf
https://doi.org/10.1210/jcem.84.5.5692
https://doi.org/10.1210/jcem.84.5.5692