Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Christopher J. Whelan"'
Autor:
Jennifer B. Permuth, Margaret A. Park, Dung-Tsa Chen, Toni Basinski, Benjamin D. Powers, Clement K. Gwede, Kaleena B. Dezsi, Maria Gomez, Shraddha L. Vyas, Tiago Biachi, Elena M. Cortizas, Sylvia Crowder, Maria Genilo-Delgado, B.Lee Green, Anna Greene, Christopher Gregg, Sarah E. Hoffe, Kun Jiang, Bora Kim, Vanitha Vasudevan, Jeronimo Garcialopez De Llano, Anjana A. Menon, Qianxing Mo, Lina M. MorenoUrazan, Shaffer Mok, Nathan Parker, Sahana Rajasekhara, Ghulam Rasool, Andrew Sinnamon, Lauren Sparks, Paul A. Stewart, Kenneth Tardif, Alexandra F. Tassielli, Jamie K. Teer, Dan Viet Tran, Kea L. Turner, Susan T. Vadaparampil, Christopher J. Whelan, Wade G. Douglas, Vic Velanovich, Andreas Karachristos, Adrian Legaspi, Kenneth Meredith, Manual A. Molina-Vega, Kevin L. Huguet, Juan P. Arnoletti, Mark Bloomston, Jose Trevino, Nipun B. Merchant, Jose M. Pimiento, Pamela J. Hodul, Mokenge Malafa, Jason Fleming, Sarah M. Judge, Daniel K. Jeong, Andrew Judge
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionCancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to ident
Externí odkaz:
https://doaj.org/article/99b382aea6824ea3b6624e0a14f602fd
Autor:
Margaret A. Park, Christopher J. Whelan, Sabeen Ahmed, Tabitha Boeringer, Joel Brown, Sylvia L. Crowder, Kenneth Gage, Christopher Gregg, Daniel K. Jeong, Heather S. L. Jim, Andrew R. Judge, Tina M. Mason, Nathan Parker, Smitha Pillai, Aliya Qayyum, Sahana Rajasekhara, Ghulam Rasool, Sara M. Tinsley, Matthew B. Schabath, Paul Stewart, Jeffrey West, Patricia McDonald, Jennifer B. Permuth
Publikováno v:
Cancers, Vol 16, Iss 13, p 2364 (2024)
For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance an
Externí odkaz:
https://doaj.org/article/20f668adb9ab499fb6b1f37284980d17
Autor:
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 461 (2024)
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize t
Externí odkaz:
https://doaj.org/article/5a610c872c3d4c0c81b99911fe84d7cd
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
Externí odkaz:
https://doaj.org/article/dec007baa85d4e4e91b6bac2af9bca15
Autor:
Dominique Abrahams, Arig Ibrahim-Hashim, Robert S. Ackerman, Joel S. Brown, Christopher J. Whelan, Megan B. Garfinkel, Robert A. Gatenby, Aaron R. Muncey
Publikováno v:
PLoS ONE, Vol 18, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/5b129c4e2b514cb7935c8765635f9de3
Autor:
Sarah C. Brüningk, Jeffrey Peacock, Christopher J. Whelan, Renee Brady-Nicholls, Hsiang-Hsuan M. Yu, Solmaz Sahebjam, Heiko Enderling
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Recurrent high grade glioma patients face a poor prognosis for which no curative treatment option currently exists. In contrast to prescribing high dose hypofractionated stereotactic radiotherapy (HFSRT, $$\ge 6$$ ≥ 6 Gy $$\times$$ × 5 in
Externí odkaz:
https://doaj.org/article/12d49fafccfc40e1a90b56b55317294b
Autor:
Mariyah Pressley, Jill A. Gallaher, Joel S. Brown, Michal R. Tomaszewski, Punit Borad, Mehdi Damaghi, Robert J. Gillies, Christopher J. Whelan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Tumors experience temporal and spatial fluctuations in oxygenation. Hypoxia inducible transcription factors (HIF-α) respond to low levels of oxygen and induce re-supply oxygen. HIF-α stabilization is typically facultative, induced by hypox
Externí odkaz:
https://doaj.org/article/80fe1800dde0464a95b640975ccb6ff5
Publikováno v:
Frontiers in Ecology and Evolution, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/b3ef8fb1df944f259c74b32f3a231b7c
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
Dormancy is an inactive period of an organism’s life cycle that permits it to survive through phases of unfavorable conditions in highly variable environments. Dormancy is not binary. There is a continuum of dormancy phenotypes that represent some
Externí odkaz:
https://doaj.org/article/7f8efb9bd7d14a93afb2d0aaf9a8dfd0
Autor:
Joy Peplinski, Margaret A. Malone, Katherine J. Fowler, Emily J. Potratz, Alexander G. Pergams, Kristie L. Charmoy, Kiran Rasheed, Stanislav S. Avdieiev, Christopher J. Whelan, Joel S. Brown
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
In nature, many multicellular and unicellular organisms use constitutive defenses such as armor, spines, and noxious chemicals to keep predators at bay. These defenses render the prey difficult and/or dangerous to subdue and handle, which confers a s
Externí odkaz:
https://doaj.org/article/0142a796e60444bf9776e078889b963a