Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher J. Wegerski"'
Autor:
C. Edwin Garner, Christopher J. Wegerski, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller, Suramya Waidyanatha
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 883-892 (2020)
2′,2′′′-Dithiobisbenzanilide (DTBBA) is a high-production-volume chemical used as a peptizing agent for rubber. The disposition and metabolism of [14C]DTBBA were determined in male and female rats and mice following oral (4, 40, or 400 mg/kg)
Externí odkaz:
https://doaj.org/article/ccfc7d63e08048ffa968a1f99f964164
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1650a320f50adfe95d94d63fa8b72d9e
https://doi.org/10.1158/1535-7163.c.6542892.v1
https://doi.org/10.1158/1535-7163.c.6542892.v1
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
Tables S1-S3, Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b76301f84d3ad65de199ac1ded585c
https://doi.org/10.1158/1535-7163.22521054.v1
https://doi.org/10.1158/1535-7163.22521054.v1
Autor:
Haleigh Howard, Eric Sung, Samuel Sperry, Christopher J. Wegerski, Tran Chinh Viet, Adina Gerson-Gurwitz, Gary G. Chiang, Garrick Packard, Andres Nevarez, Paul A. Sprengeler, Joan Chen, Jocelyn Staunton, Kevin R. Webster, Maria Barrera, Reich Siegfried Heinz, Ana Parra, Nathan P Young, Alan Xiang, Justin T. Ernst, Sarah Fish, Theodore Michels, Peggy A. Thompson, Christian Nilewski, Jeff Clarine, Boreth Eam
Publikováno v:
Molecular Cancer Therapeutics. 20:26-36
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14e9801128ca86bd9b7b59cc4c5bb4e
https://doi.org/10.1158/1535-7163.mct-19-0973
https://doi.org/10.1158/1535-7163.mct-19-0973
Autor:
Peggy A. Thompson, Garrick Kenneth Packard, Theodore Michels, Boreth Eam, Alan X. Xiang, Reich Siegfried Heinz, Sarah Fish, Christian Nilewski, Paul A. Sprengeler, Justin T. Ernst, Christopher J. Wegerski
Publikováno v:
Organic Letters. 22:6257-6261
Rocaglates, rocaglamides, and related flavagline natural products exert their remarkable anticancer activity through inhibition of eukaryotic initiation factor 4A (eIF4A) but generally display suboptimal drug-like properties. In our efforts to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6c6ced9312dfa787e7deaa5389be5
https://doi.org/10.1021/acs.orglett.0c01944
https://doi.org/10.1021/acs.orglett.0c01944
Autor:
J. Michael Sanders, Jacob D. McDonald, Benjamin C. Moeller, Suramya Waidyanatha, Melanie Doyle-Eisele, C. Edwin Garner, Christopher J. Wegerski
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 883-892 (2020)
Toxicology Reports, Vol 7, Iss, Pp 883-892 (2020)
Highlights • 2′,2′′′-Dithiobisbenzanilide (DTBBA) is a chemical used as a peptizing agent for rubber. • Humane exposure to DTBBA is possible via oral and dermal routes. • DTBBA is well-absorbed in rodents following oral and dermal admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f63b86461156a14666608432afce413
http://europepmc.org/articles/PMC7390853
http://europepmc.org/articles/PMC7390853
Autor:
Christopher J. Wegerski, Jacob D. McDonald, Suramya Waidyanatha, Barry S. McIntyre, C. Edwin Garner, Melanie Doyle-Eisele, Esra Mutlu
Publikováno v:
Xenobiotica
1. 2-Hydroxy-4-methoxybenzophenone (HMB) is a common ingredient in personal care products and used as an UV stabilizer. In these studies, disposition and metabolism of [(14)C]HMB in rats and mice was assessed following single gavage administration (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cd32be81d4d3ca85107ba1d4622ac5
https://doi.org/10.1080/00498254.2019.1680906
https://doi.org/10.1080/00498254.2019.1680906
Autor:
Nathan P Young, Paul A. Sprengeler, Christopher J. Wegerski, Samuel Sperry, Tran Chinh Viet, Andres Nevarez, Kevin R. Webster, Jocelyn Staunton, Haleigh Howard, Gary G. Chiang, Jim R Appleman, Alan Xiang, Theodore Michels, Reich Siegfried Heinz, Jolene Molter, Garrick Packard, Jeff Clarine, Christian Nilewski, Sarah Fish, Justin T. Ernst, Peggy A. Thompson, Boreth Eam, Joan Chen
Publikováno v:
Journal of medicinal chemistry. 63(11)
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66b781e59583b73ced8e0594522c507
https://pubmed.ncbi.nlm.nih.gov/32470302
https://pubmed.ncbi.nlm.nih.gov/32470302
Autor:
Nathan P. Young, Gary G. Chiang, Andres Nevarez, Joan Chen, Tran Chinh Viet, Reich Siegfried Heinz, Theodore Michels, Eric Sung, Haleigh Howard, Christopher J. Wegerski, Ana Parra, Gregory S. Parker, Boreth Eam, Alan Xiang, Samuel Sperry, Jocelyn Staunton, Maria Barrera, Christian Nilewski, Kevin R. Webster, Garrick Packard, Sarah Fish, Jeff Clarine, Paul A. Sprengeler, Peggy A. Thompson, Ivy Nj Hung, Justin T. Ernst
Publikováno v:
Cancer Research. 78:DDT02-05
eFT226: A Selective and Highly Potent Inhibitor of Eukaryotic Initiation Factor 4A (eIF4A), a Novel Approach for the Treatment of Cancer Siegfried H Reich, Peggy A Thompson, Justin T Ernst, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Maria Bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23be4e92a65700d1d634cbd6a08772ef
https://doi.org/10.1158/1538-7445.am2018-ddt02-05
https://doi.org/10.1158/1538-7445.am2018-ddt02-05
Autor:
C. Edwin Garner, Kristen Ryan, Christopher J. Wegerski, Suramya Waidyanatha, Jacob D. McDonald, Melanie Doyle-Eisle, J. Michael Sanders
Publikováno v:
Toxicology and Applied Pharmacology. 339:151-160
β-N-methylamino-l-alanine (L-BMAA) is produced by cyanobacteria (blue-green algae). Human exposure to L-BMAA occurs via consumption of L-BMAA-contaminated water and food. It is speculated that exposure to L-BMAA, and subsequent brain accumulation, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea81a5cad39a8129c4c3e90e73b35978
https://doi.org/10.1016/j.taap.2017.12.008
https://doi.org/10.1016/j.taap.2017.12.008