Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Christopher J. Tonkin"'
Autor:
Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-31 (2024)
Abstract Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that o
Externí odkaz:
https://doaj.org/article/dd19e4fc213b4406a1fdbe90f4f928eb
Autor:
Tamara L. Baker, Alessandro D. Uboldi, Christopher J. Tonkin, David K. Wright, Anh Vo, Trevor Wilson, Richelle Mychasiuk, Stuart J. McDonald, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
IntroductionPost-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI), and neuroinflammation is implicated in increased seizure susceptibility and epileptogenesis. However, how common clinical factors, such as in
Externí odkaz:
https://doaj.org/article/4592529e97cd40d78e368d66a3902479
Autor:
Tamara L. Baker, Mujun Sun, Bridgette D. Semple, Shiraz Tyebji, Christopher J. Tonkin, Richelle Mychasiuk, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In particular, the degree of neuro
Externí odkaz:
https://doaj.org/article/f8e8f34c58dd4a44bc9eaeddbae91438
Autor:
V. Vern Lee, Louise M. Judd, Aaron R. Jex, Kathryn E. Holt, Christopher J. Tonkin, Stuart A. Ralph
Publikováno v:
mSystems, Vol 6, Iss 2 (2021)
ABSTRACT Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the gene product. However, this has been poorly characterized in apicomplexans, a major phylum of some of the most im
Externí odkaz:
https://doaj.org/article/5e6e2bd160d641ada2a753d8ee4b707c
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be pass
Externí odkaz:
https://doaj.org/article/1b9b32f3fb3b4f9e9e7a4bed4df0308b
Autor:
Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K. Thompson, Alexei A. Kouzmitchev, Hayley E. Bullen, Paul R. Gilson, Alan F. Cowman, Christopher J. Tonkin
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry is enabled by
Externí odkaz:
https://doaj.org/article/e57a13863f35463ca89cb2fe9e8b1b58
Autor:
Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew I. Webb, Christopher J. Tonkin
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Toxoplasma gondii infects approximately 30% of the world’s population, causing disease primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma secretes and exports effector proteins that modulate the host dur
Externí odkaz:
https://doaj.org/article/ea7a3291199047328178731b63d09cfa
Autor:
Adit Naor, Michael W. Panas, Nicole Marino, Michael J. Coffey, Christopher J. Tonkin, John C. Boothroyd
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT The obligate intracellular parasite Toxoplasma gondii controls its host cell from within the parasitophorous vacuole (PV) by using a number of diverse effector proteins, a subset of which require the aspartyl protease 5 enzyme (ASP5) and/or
Externí odkaz:
https://doaj.org/article/7435798edd5842b18076726fbe510eb7
Autor:
Melanie J. Williams, Hernan Alonso, Marta Enciso, Saskia Egarter, Lilach Sheiner, Markus Meissner, Boris Striepen, Brian J. Smith, Christopher J. Tonkin
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a ty
Externí odkaz:
https://doaj.org/article/d0c460df28c34814998e886ac78c3a7f
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1 (2013)
Externí odkaz:
https://doaj.org/article/9b38d9b00d434f238291f18a87ac9061