Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher J. Tame"'
Autor:
Han Dai, Robert P. Law, John P. Evans, Gillian F. Watt, Chun-wa Chung, Markus A. Queisser, John D. Harling, Antonia J. Lewis, Marcus Bantscheff, João Osvaldo Rodrigues Nunes, Adam Flinders, Paul Scott-Stevens, Andrew B. Benowitz, Peter Stacey, Christopher J. Tame, Karol Buda, Diana Klimaszewska, Marcel Muelbaier, Nico Zinn
Publikováno v:
Angewandte Chemie. 133:23515-23522
Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology indications. We report the design and characterisation of GSK215, a poten
Autor:
Dongming Qian, Christopher J. Tame, Agnieszka Konopacka, Han Dai, Ian Churcher, Chun-wa Chung, John D. Harling, Esther Fernández, Gillian F. Watt, Markus A. Queisser, Christopher P. Tinworth, Andrew B. Benowitz, Jane Denyer, Jenni Cryan, Fan Jiang
Publikováno v:
ACS chemical biology. 15(9)
The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family inhibitors and FDA approved drugs. Recently
Publikováno v:
Tetrahedron: Asymmetry. 28:1384-1393
The absolute configuration of two novel αvβ6 integrin inhibitors was established via degradation to the corresponding C3-aryl substituted butyrolactone. The configuration of the resulting lactones was established by asymmetric synthesis using 1,4-a
Our synthesis of the CDE ring fragment of pectenotoxin-4 utilised two key steps to make the complex bicyclic ketal unit: (i) a rhodium-catalysed vinyl group 1,4-addition as the major C-C bond forming step; (ii) a stereoselective Sharpless Asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5bafe23220b5f7df266e4c9b5d91e8
https://doi.org/10.1039/c9sc01761e
https://doi.org/10.1039/c9sc01761e
Autor:
Sorif Uddin, Graham G. A. Inglis, Paul Rowland, Christopher J. Tame, Christopher N. Luscombe, Nick Barton, Natalie Wellaway, Anthony William James Cooper, Josie Morrell, Giovanni Vitulli, David Perez, Augustin Amour, Simon Peace, Craig Jamieson
Publikováno v:
Journal of Medicinal Chemistry. 59:7239-7251
A four step process of high quality modelling of existing data, deconstruction, identification of replacement cores and an innovative synthetic re-growth strategy led to the rapid discovery of a novel oral series of PI3K δ inhibitors with promising
Autor:
Tom D. Sheppard, Christopher J. Tame, Helen C. Hailes, Dejan-Krešimir Bučar, Robert W. Foster
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
L-Arabinose is an abundant resource available as a waste product of the sugar beet industry. Through use of a hydrazone-based strategy, L-arabinose was selectively dehydrated to form a chiral tetrahydrofuran on a multi-gram scale without the need for
Autor:
Helen C. Hailes, Christopher J. Tame, Laure Benhamou, Dejan-Krešimir Bučar, Robert W. Foster, Michael J. Porter, Tom D. Sheppard
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
The [4+2] cycloaddition of 3-alkoxyfurans with N-substituted maleimides provides the first general route for preparing endo-cantharimides. Unlike the corresponding reaction with 3H furans, the reaction can tolerate a broad range of 2-substitued furan
Publikováno v:
Advanced Synthesis & Catalysis. 355:2353-2360
(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, the presence
Autor:
Augustin Amour, Nick Barton, Anthony W. J. Cooper, Graham Inglis, Craig Jamieson, Christopher N. Luscombe, Josie Morrell, Simon Peace, David Perez, Paul Rowland, Christopher J. Tame, Sorif Uddin, Giovanni Vitulli, Natalie Wellaway
Publikováno v:
Journal of medicinal chemistry. 59(17)
Autor:
Robert W. Foster, Tom D. Sheppard, Dejan-Krešimir Bučar, Helen C. Hailes, Christopher J. Tame
Publikováno v:
ChemInform. 47
L-Arabinose is an abundant resource available as a waste product of the sugar beet industry. Through use of a hydrazone-based strategy, L-arabinose was selectively dehydrated to form a chiral tetrahydrofuran on a multi-gram scale without the need for