Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christopher J. Stairiker"'
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Christopher J. Stairiker, Sophia Xiao Pfister, Eleanore Hendrickson, Wenjing Yang, Tao Xie, Catherine Lee, Haikuo Zhang, Christopher Dillon, Graham D. Thomas, Shahram Salek-Ardakani
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Enhancer of Zeste Homolog 2 (EZH2) inhibitors (EZH2i) are approved to treat certain cancer types. Previous studies have suggested the potential to combine EZH2i with immune checkpoint blockade targeting coinhibitory receptors like PD-(L)1 and CTLA-4,
Externí odkaz:
https://doaj.org/article/b009c34667ac4334bd59e24939d35690
Autor:
Roberto Tinoco, Emily N. Neubert, Christopher J. Stairiker, Monique L. Henriquez, Linda M. Bradley
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Effective T cell differentiation during acute virus infections leads to the generation of effector T cells that mediate viral clearance, as well as memory T cells that confer protection against subsequent reinfection. While inhibitory immune checkpoi
Externí odkaz:
https://doaj.org/article/b9bcee28e3d24f1e9ef09d6a55c91578
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Enhancer of zeste 2 (EZH2) is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) that mediates di- and trimethylation of histone 3 lysine 27 effectively precluding successful gene transcription at these loci. This class of epigenetic m
Externí odkaz:
https://doaj.org/article/9c18db78ad944140a8fb906df86396e2
Autor:
Jennifer L. Hope, Panagiota I. Spantidea, Caoimhe H. Kiernan, Christopher J. Stairiker, Laurine C. Rijsbergen, Marjan van Meurs, Inge Brouwers-Haspels, Yvonne M. Mueller, Delia J. Nelson, Linda M. Bradley, Joachim G. J. V. Aerts, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The immune system, and in particular, cytotoxic CD8+ T cells (CTLs), plays a vital part in the prevention and elimination of tumors. In many patients, however, CTL-mediated tumor killing ultimately fails in the clearance of cancer cells resulting in
Externí odkaz:
https://doaj.org/article/244d90e4006c4431ab1b57e407dbf2cf
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Effective adaptive immune responses are characterized by stages of development and maturation of T and B cell populations that respond to disturbances in the host homeostasis in cases of both infections and cancer. For the T cell compartment, this be
Externí odkaz:
https://doaj.org/article/69cfb3667b96436ab3b9bffae796676b
Autor:
Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importan
Externí odkaz:
https://doaj.org/article/045e79ae899f4457b4050ae3c4bfc370
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f2bca13f38066d8dc8b044c3fbbe6
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Monique L. Henriquez, Hyungseok Seo, Xue Lei, Eric S. Wang, Roberto Tinoco, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Summary/AbstractWe previously identified the adhesion molecule PSGL-1 as a T cell intrinsic immune checkpoint regulator of T cell exhaustion. Here we show that the ability of PSGL-1 to restrain TCR sginaling correlates with decreased expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb51d4fbb8372cd62d613e21bec9d52
https://doi.org/10.1101/2022.01.24.477602
https://doi.org/10.1101/2022.01.24.477602
Autor:
Haikuo Zhang, Shahram Salek-Ardakani, Catherine Lee, Wenjing Yang, Christopher P. Dillon, Sophia Pfister, Eleanore Hendrickson, Christopher J. Stairiker, Tao Xie, Graham D. Thomas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Enhancer of Zeste Homolog 2 (EZH2) inhibitors (EZH2i) are approved to treat certain cancer types. Previous studies have suggested the potential to combine EZH2i with immune checkpoint blockade targeting coinhibitory receptors like PD-(L)1 and CTLA-4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d8949c39840d92a5560137d4a2c1a0
https://doi.org/10.3389/fimmu.2021.770080
https://doi.org/10.3389/fimmu.2021.770080