Výsledky vyhledávání - "Christopher J. Sleigh"

Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods

Autor: Lyrelle S. Lloyd, Steven R. Coombes, Richard J. Lewis, Ryan E. Mewis, Christopher J. Sleigh, Ralph W. Adams, Gary G. R. Green, Michael A. Bernstein, Simon B. Duckett

Publikováno v: Journal of the American Chemical Society. 134:12904-12907

The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5a98171eeb1ac8e535399307e9097b
https://doi.org/10.1021/ja3051052

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Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates

Autor: Rhona Sinclair, Nicholas I. Pedge, Christopher J. Sleigh, James E. M. Booker, Edward Way, Marijan Štefinović, Debra Ainge, Luis-Manuel Vaz

Publikováno v: Organic Process Research & Development. 14:72-84

The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranylmethoxy)phenyl ester (2), utilising a SNAr coupling, the hydrogenation of a nitro moiety and the conversion of a chiral aceton

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https://doi.org/10.1021/op900172t

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Optimising reaction performance in the pharmaceutical industry by monitoring with NMR

Autor: Michael A. Bernstein, Marijan Štefinović, Christopher J. Sleigh

Publikováno v: Magnetic Resonance in Chemistry. 45:564-571

Quality assurance and process understanding are assuming increasing importance in the production of Active Pharmaceutical Ingredients (APIs). NMR has the potential to report on physical processes, quantities, structures, and speciation as chemical re

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https://doi.org/10.1002/mrc.2007

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Ruthenium Dihydride Complexes: NMR Studies of Intramolecular Isomerization and Fluxionality Including the Detection of Minor Isomers by Parahydrogen-Induced Polarization

Autor: Danièle Schott, Martin G. Partridge, Simon B. Duckett, Roger J. Mawby, John P. Lowe, Christopher J. Sleigh

Publikováno v: Inorganic Chemistry. 41:2960-2970

NMR studies reveal that complexes Ru(CO)(2)(H)(2)L(2) (L = PMe(3), PMe(2)Ph, and AsMe(2)Ph) can have three geometries, ccc, cct-L, and cct-CO, with equilibrium ratios that are highly dependent on the electronic properties of L; the cct-L form is favo

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https://doi.org/10.1021/ic011255w

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Activation of H2 by halocarbonyl bis-phosphine and bis-arsine iridium(i) complexes. The use of parahydrogen induced polarisation to detect species present at low concentration and investigate their reactivityBased on the presentation given at Dalton Discussion No. 4, 10–13th January 2002, Kloster Banz, Germany

Autor: Simon B. Duckett, Christopher J. Sleigh, Graham K. Barlow, Sarah K. Hasnip, Diana R. Taylor, Simon A. Colebrooke, Michael J. Taylor

Publikováno v: Journal of the Chemical Society, Dalton Transactions. :743-751

The iridium phosphine complexes Ir(CO)Cl(L)2 [L = PPh3, PMe3, AsPh3 and PPh2Cl, and L2 = (PPh2Cl)(PPh3)] add H2 to form the corresponding dihydrides IrH2(CO)Cl(L)2. These products are detected at enhanced levels of sensitivity through the 1H NMR sign

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https://doi.org/10.1039/b107444j

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NMR Studies of Ru3(CO)10(PMe2Ph)2 and Ru3(CO)10(PPh3)2 and Their H2 Addition Products: Detection of New Isomers with Complex Dynamic Behavior

Autor: Damir Blazina, Simon B. Duckett, Brian F.G. Johnson, Joost A. B. Lohman, Paul J. Dyson, Christopher J. Sleigh

Publikováno v: Journal of the American Chemical Society. 123:9760-9768

The clusters Ru(3)(CO)(10)L(2), where L = PMe(2)Ph or PPh(3), are shown by NMR spectroscopy to exist in solution in at least three isomeric forms, one with both phosphines in the equatorial plane on the same ruthenium center and the others with phosp

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https://doi.org/10.1021/ja004245n

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Observation of New Intermediates in the Reaction of Dihydrogen with Iridium, Rhodium, and Mixed Metal A-Frame Complexes with Parahydrogen-Induced Polarization

Autor: Christopher J. Sleigh, Susan M. Oldham, Simon B. Duckett,‡ and, James F. Houlis, Richard Eisenberg

Publikováno v: Organometallics. 19:2985-2993

The reaction of hydrogen with iridium and rhodium μ-S A-frame complexes has been investigated using parahydrogen-induced polarization (PHIP) NMR spectroscopy. The reaction of Ir2(μ-S)(CO)2(dppm)2 where dppm = bis(diphenylphosphino)methane with hydr

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https://doi.org/10.1021/om000391q

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Luminescent Iridium(I) Diethyldithiocarbamate Complexes: Synthesis, Structure, and Reactivity Including Stereoselective Hydrogen Oxidative Addition

Autor: Earl W. Reed, Christopher J. Sleigh, Simon B. Duckett, and Joost A. B. Lohman, Gianfranco Suardi, Brian P. Cleary, Richard Eisenberg, Melinda S. Rau

Publikováno v: Journal of the American Chemical Society. 119:7716-7725

A series of neutral Ir(I) complexes IrLL‘(Et2dtc) (L = L‘ = CO PPh3, P(OPh)3; L = CO, L‘ = PPh3; L + L‘ = 1,2-bis(diphenylphosphino)ethane, 1,5-cyclooctadiene, 1,2-bis(di(pentafluorophenyl)phosphin...

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https://doi.org/10.1021/ja970208t

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A comparison of capillary-scale LC-NMR with alternative techniques: spectroscopic and practical considerations

Autor: Michael A. Bernstein, Richard J. Lewis, Christopher J. Sleigh, Sara J. Duncan

Publikováno v: Magnetic resonance in chemistry : MRC. 43(9)

Experimental and practical details for the use of capillary LC (CapLC)–NMR are reported. The capillary NMR probe has high sensitivity and excellent flow characteristics and we found CapLC–NMR to be best suited to samples that are truly mass limit

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https://pubmed.ncbi.nlm.nih.gov/16049949

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