Zobrazeno 1 - 10
of 935
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Autor:
Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Formaldehyde is a potent toxic electrophile at high concentrations; however its potential regulatory roles remain unknown. Here, the authors report that formaldehyde can react with terminal proline-containing proteins to generate stable 5,5-bicyclic
Externí odkaz:
https://doaj.org/article/2a8406e75d014635a9536287ad9f6a51
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian regulation in plants and humans and is involved in embryonic development and cell proliferation. JMJD5 is a 2-oxoglutarate (2OG) and Fe(II) dependent oxygenase o
Externí odkaz:
https://doaj.org/article/13be38b6f6d444ab8e90b762575e7b19
Autor:
Stefan Krco, Samuel J. Davis, Pallav Joshi, Liam A. Wilson, Marcelo Monteiro Pedroso, Andrew Douw, Christopher J. Schofield, Philip Hugenholtz, Gerhard Schenk, Marc T. Morris
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
β-Lactams are the most widely employed antibiotics in clinical settings due to their broad efficacy and low toxicity. However, since their first use in the 1940s, resistance to β-lactams has proliferated to the point where multi-drug resistant orga
Externí odkaz:
https://doaj.org/article/36419f8473744304b285ada2a5f77a80
Autor:
Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The development of IDH variant inhibitors is a breakthrough as it is the first time metabolism has been successfully targeted by small molecule drugs in cancer. Here the authors report studies on resistance to the pioneer drug ivosidenib leading to i
Externí odkaz:
https://doaj.org/article/e3e859d6d730417f8d6ec356de38fe1b
Autor:
Rasheduzzaman Chowdhury, Martine I. Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J. Schofield
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The JmjC family of 2-oxoglutarate dependent oxygenases catalyse a range of hydroxylation and demethylation reactions in humans and other animals. Jumonji domain-containing 7 (JMJD7) is a JmjC (3S)-lysyl-hydroxylase that catalyses the modific
Externí odkaz:
https://doaj.org/article/77195d9f25814b63ac7af57680c41a8a
Autor:
Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
N ε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone N ε-methyllysine readers and erasers can manifest selectivity is of fundamental and
Externí odkaz:
https://doaj.org/article/099bbfd2e1894d158c026e859ca05b14
Autor:
Vida Štrancar, Katarina P. van Midden, Daniel Krahn, Kyoko Morimoto, Marko Novinec, Christiane Funk, Simon Stael, Christopher J. Schofield, Marina Klemenčič, Renier A.L. van der Hoorn
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105247- (2022)
Summary: Metacaspases are essential cysteine proteases present in plants, fungi, and protists that are regulated by calcium binding and proteolytic maturation through mechanisms not yet understood. Here, we developed and validated activity-based prob
Externí odkaz:
https://doaj.org/article/24c8f0d0a12d4df987ff05d968906b07
Autor:
Shuang Liu, Martine I. Abboud, Tobias John, Victor Mikhailov, Ingvild Hvinden, John Walsby-Tickle, Xiao Liu, Ilaria Pettinati, Tom Cadoux-Hudson, James S. O. McCullagh, Christopher J. Schofield
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that a
Externí odkaz:
https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e6
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The human 2-oxoglutarate (2OG) oxygenases FIH and AspH are relevant drug targets. Here, the authors show that synthetic and naturally occurring 2OG derivatives can selectively modulate FIH and AspH activities, suggesting that these compounds may serv
Externí odkaz:
https://doaj.org/article/f65c6124dc4f4697b8a6aadeea9cfc56