Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Christopher J. R. Illingworth"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The transmission bottleneck describes the number of viral particles that initiate an infection in a new host. Previous studies have used genome sequence data to suggest that transmission bottlenecks for influenza and SARS-CoV-2 involve few v
Externí odkaz:
https://doaj.org/article/54dff7b242dc4b99aea5535ed74d21d9
Autor:
Sema Nickbakhsh, Joseph Hughes, Nicolaos Christofidis, Emily Griffiths, Sharif Shaaban, Jessica Enright, Katherine Smollett, Kyriaki Nomikou, Natasha Palmalux, Lily Tong, Stephen Carmichael, Vattipally B. Sreenu, Richard Orton, Emily J. Goldstein, Rachael M. Tomb, The COVID-19 Genomics UK (COG-UK) Consortium, Kate Templeton, Rory N. Gunson, Ana da Silva Filipe, Catriona Milosevic, Emma Thomson, David L. Robertson, Matthew T. G. Holden, Christopher J. R. Illingworth, Alison Smith-Palmer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks a
Externí odkaz:
https://doaj.org/article/8c19f7f6230d4d829cce31344f4ca724
Autor:
Steven A. Kemp, Mark T. K. Cheng, William L. Hamilton, Kimia Kamelian, The Indian SARS-CoV-2 Genomics Consortium (INSACOG), Sujit Singh, Partha Rakshit, Anurag Agrawal, Christopher J. R. Illingworth, Ravindra K. Gupta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-va
Externí odkaz:
https://doaj.org/article/7f735d646c19466da91bc5f852af5b82
Autor:
Stephen R. Doyle, Christopher J. R. Illingworth, Roz Laing, David J. Bartley, Elizabeth Redman, Axel Martinelli, Nancy Holroyd, Alison A. Morrison, Andrew Rezansoff, Alan Tracey, Eileen Devaney, Matthew Berriman, Neil Sargison, James A. Cotton, John S. Gilleard
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and compa
Externí odkaz:
https://doaj.org/article/553c0dd727ea4f46b528685296917943
Autor:
Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis
Publikováno v:
Nature. 615:134-142
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t
Autor:
Christopher J R Illingworth, Jayna Raghwani, David Serwadda, Nelson K Sewankambo, Merlin L Robb, Michael A Eller, Andrew R Redd, Thomas C Quinn, Katrina A Lythgoe
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008171 (2020)
In the absence of effective antiviral therapy, HIV-1 evolves in response to the within-host environment, of which the immune system is an important aspect. During the earliest stages of infection, this process of evolution is very rapid, driven by a
Externí odkaz:
https://doaj.org/article/237886b505ae4ec4aa2c15eb448850d5
Autor:
Paul Flowers, Ruth Leiser, Fiona Mapp, Julie McLeod, Oliver Stirrup, Christopher J. R. Illingworth, James Blackstone, Judith Breuer
Publikováno v:
British Journal of Health Psychology.
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006905 (2019)
The mechanism by which hepatitis C virus (HCV) gains entry into cells is a complex one, involving a broad range of host proteins. Entry is a critical phase of the viral lifecycle, and a potential target for therapeutic or vaccine-mediated interventio
Externí odkaz:
https://doaj.org/article/67c7751607794c20b1be115032dd29b5
The transmission bottleneck describes the number of viral particles that found an infection in a new host. Previous studies have used genome sequence data to suggest that transmission bottlenecks for influenza and SARS-CoV-2 involve few viral particl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5f82c0ef6a71ba1f033879462c0025
https://doi.org/10.1101/2023.04.14.536864
https://doi.org/10.1101/2023.04.14.536864
Autor:
Christopher J. R. Illingworth, Alexandra Y. Kreins, Adriana Margarit-Soler, Tim Best, Patricia Dyal, Giovanna Lucchini, Kanchan Rao, Rachel Williams, Austen Worth, Judith Breuer
Antiviral drugs causing viral mutagenesis have shown value against a broad range of RNA viruses causing respiratory illnesses. While drug-induced accumulation of mutations generally decreases viral fitness, the potential for mutagenesis to generate e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48388f1d87af31a37fa9b263c5c92187
https://doi.org/10.1101/2022.09.02.22279474
https://doi.org/10.1101/2022.09.02.22279474