Výsledky vyhledávání - "Christopher J. Pazoles"

The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress

Autor: Alberto J. Montero, C. Marcela Diaz-Montero, Christopher J. Pazoles, Wei Feng, Lijian Shao, Daohong Zhou, Yong Wang, Abdel-Aziz A. Zidan

Publikováno v: Free Radical Biology and Medicine. 52:1560-1568

The oxidized glutathione mimetic NOV-002, is a unique anti-tumor agent that not only has the ability to inhibit tumor cell proliferation, survival, and invasion, but in some settings can also ameliorate cytotoxic chemotherapy-induced hematopoietic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5217d91cf09aa456a05eab2178125735
https://doi.org/10.1016/j.freeradbiomed.2012.02.007

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S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs

Autor: Yefim Manevich, Danyelle M. Townsend, Joachim D. Uys, Woodrow J. Coker, Kenneth D. Tew, Christina L. Grek, Christopher J. Pazoles

Publikováno v: Cancer Research. 72:2383-2393

Many cancer drugs impact cancer cell redox regulatory mechanisms and disrupt redox homeostasis. Pharmacodynamic biomarkers that measure therapeutic efficacy or toxicity could improve patient management. Using immunoblot analyses and mass spectrometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee65c25db9abb85bd5d5a117a41b65b0
https://doi.org/10.1158/0008-5472.can-11-4088

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Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic

Autor: Joachim D. Uys, Kenneth D. Tew, Yefim Manevich, Danyelle M. Townsend, Christopher J. Pazoles, Lindsay DeVane, Tracy E. Garret, Lin He

Publikováno v: Biomedicine & Pharmacotherapy. 64:493-498

NOV-002 is a glutathione disulfide (GSSG) mimetic that is in Phase III clinical trials for the treatment of advanced non-small cell lung cancer and other oncology indications. GSSG is reduced by glutathione reductase (GR) to form glutathione (GSH), t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfea3f7f240bea23ffa8050934201e5
https://doi.org/10.1016/j.biopha.2010.01.003

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Novel Role for Glutathione S-Transferase π

Autor: Yefim Manevich, Danyelle M. Townsend, Christopher J. Pazoles, Kenneth D. Tew, Lin He, Steven Hutchens

Publikováno v: Journal of Biological Chemistry. 284:436-445

Glutathione S-transferase Pi (GSTπ) is a marker protein in many cancers and high levels are linked to drug resistance, even when the selecting drug is not a substrate. S-Glutathionylation of proteins is critical to cellular stress response, but char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::100fd5b6a772c641d138f4a72aa2de2f
https://doi.org/10.1074/jbc.m805586200

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NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance

Autor: Danyelle M. Townsend, Tracy E. Garrett, Christopher J. Pazoles, Steven Hutchens, Lin He, Kenneth D. Tew

Publikováno v: Cancer Research. 68:2870-2877

NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor response) and improved tolerance to chemotherapy (e.g., hematologic rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ce197791fb2ad48f83acf2e557a57c
https://doi.org/10.1158/0008-5472.can-07-5957

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Role of Intracellular Proteins in the Regulation of Calcium Action and Transmitter Release During Exocytosis

Autor: Carl E. Creutz, Oren Zinder, Harvey B. Pollard, Christopher J. Pazoles

A central problem in cellular neurobiology is how the process of exocytosis of transmitters and hormones is regulated at the molecular level. Calcium is important in the process and may act by initiating the formation of fusion complexes of secretory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4947dcda5694205df593595b57eaae11
https://doi.org/10.1159/000388818

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Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy

Autor: John S. Kuo, Mohammed Farhoud, Jamey P. Weichert, Benjamin Titz, Perry J. Pickhardt, Kyle I. Swanson, Paul A. Clark, Christopher J. Pazoles, Irawati Kandela, Abram M. Vaccaro, John M. Floberg, Anne M. Traynor, Anatoly Pinchuk, Joseph Grudzinski, Lance T. Hall, William T. Clarke, Marc Longino, Hong En Chen

Publikováno v: Science Translational Medicine. 6

Many solid tumors contain an overabundance of phospholipid ethers relative to normal cells. Capitalizing on this difference, we created cancer-targeted alkylphosphocholine (APC) analogs through structure-activity analyses. Depending on the iodine iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd01fbcfb07e22ec38e8ef7b3657b2
https://doi.org/10.1126/scitranslmed.3007646

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