Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Christopher J. Pazoles"'
Autor:
Kenneth D. Tew, Christopher J. Pazoles, Woodrow J. Coker, Yefim Manevich, Joachim D. Uys, Danyelle M. Townsend, Christina L. Grek
PDF file - 84K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2224690926e40ac9db5c6316788503c7
https://doi.org/10.1158/0008-5472.22395419
https://doi.org/10.1158/0008-5472.22395419
Autor:
Kenneth D. Tew, Christopher J. Pazoles, Woodrow J. Coker, Yefim Manevich, Joachim D. Uys, Danyelle M. Townsend, Christina L. Grek
PDF file - 5MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213f612ef4e0e1baba491e4c8d5a1e3d
https://doi.org/10.1158/0008-5472.22395422.v1
https://doi.org/10.1158/0008-5472.22395422.v1
Autor:
Kenneth D. Tew, Christopher J. Pazoles, Woodrow J. Coker, Yefim Manevich, Joachim D. Uys, Danyelle M. Townsend, Christina L. Grek
PDF file - 2.1MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374afc556a4f5fac4466ed98857d3cb8
https://doi.org/10.1158/0008-5472.22395425
https://doi.org/10.1158/0008-5472.22395425
Autor:
Alberto J. Montero, C. Marcela Diaz-Montero, Christopher J. Pazoles, Wei Feng, Lijian Shao, Daohong Zhou, Yong Wang, Abdel-Aziz A. Zidan
Publikováno v:
Free Radical Biology and Medicine. 52:1560-1568
The oxidized glutathione mimetic NOV-002, is a unique anti-tumor agent that not only has the ability to inhibit tumor cell proliferation, survival, and invasion, but in some settings can also ameliorate cytotoxic chemotherapy-induced hematopoietic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5217d91cf09aa456a05eab2178125735
https://doi.org/10.1016/j.freeradbiomed.2012.02.007
https://doi.org/10.1016/j.freeradbiomed.2012.02.007
Autor:
Yefim Manevich, Danyelle M. Townsend, Joachim D. Uys, Woodrow J. Coker, Kenneth D. Tew, Christina L. Grek, Christopher J. Pazoles
Publikováno v:
Cancer Research. 72:2383-2393
Many cancer drugs impact cancer cell redox regulatory mechanisms and disrupt redox homeostasis. Pharmacodynamic biomarkers that measure therapeutic efficacy or toxicity could improve patient management. Using immunoblot analyses and mass spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee65c25db9abb85bd5d5a117a41b65b0
https://doi.org/10.1158/0008-5472.can-11-4088
https://doi.org/10.1158/0008-5472.can-11-4088
Autor:
Joachim D. Uys, Kenneth D. Tew, Yefim Manevich, Danyelle M. Townsend, Christopher J. Pazoles, Lindsay DeVane, Tracy E. Garret, Lin He
Publikováno v:
Biomedicine & Pharmacotherapy. 64:493-498
NOV-002 is a glutathione disulfide (GSSG) mimetic that is in Phase III clinical trials for the treatment of advanced non-small cell lung cancer and other oncology indications. GSSG is reduced by glutathione reductase (GR) to form glutathione (GSH), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfea3f7f240bea23ffa8050934201e5
https://doi.org/10.1016/j.biopha.2010.01.003
https://doi.org/10.1016/j.biopha.2010.01.003
Autor:
Yefim Manevich, Danyelle M. Townsend, Christopher J. Pazoles, Kenneth D. Tew, Lin He, Steven Hutchens
Publikováno v:
Journal of Biological Chemistry. 284:436-445
Glutathione S-transferase Pi (GSTπ) is a marker protein in many cancers and high levels are linked to drug resistance, even when the selecting drug is not a substrate. S-Glutathionylation of proteins is critical to cellular stress response, but char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100fd5b6a772c641d138f4a72aa2de2f
https://doi.org/10.1074/jbc.m805586200
https://doi.org/10.1074/jbc.m805586200
Autor:
Danyelle M. Townsend, Tracy E. Garrett, Christopher J. Pazoles, Steven Hutchens, Lin He, Kenneth D. Tew
Publikováno v:
Cancer Research. 68:2870-2877
NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor response) and improved tolerance to chemotherapy (e.g., hematologic rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ce197791fb2ad48f83acf2e557a57c
https://doi.org/10.1158/0008-5472.can-07-5957
https://doi.org/10.1158/0008-5472.can-07-5957
A central problem in cellular neurobiology is how the process of exocytosis of transmitters and hormones is regulated at the molecular level. Calcium is important in the process and may act by initiating the formation of fusion complexes of secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4947dcda5694205df593595b57eaae11
https://doi.org/10.1159/000388818
https://doi.org/10.1159/000388818
Autor:
John S. Kuo, Mohammed Farhoud, Jamey P. Weichert, Benjamin Titz, Perry J. Pickhardt, Kyle I. Swanson, Paul A. Clark, Christopher J. Pazoles, Irawati Kandela, Abram M. Vaccaro, John M. Floberg, Anne M. Traynor, Anatoly Pinchuk, Joseph Grudzinski, Lance T. Hall, William T. Clarke, Marc Longino, Hong En Chen
Publikováno v:
Science Translational Medicine. 6
Many solid tumors contain an overabundance of phospholipid ethers relative to normal cells. Capitalizing on this difference, we created cancer-targeted alkylphosphocholine (APC) analogs through structure-activity analyses. Depending on the iodine iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd01fbcfb07e22ec38e8ef7b3657b2
https://doi.org/10.1126/scitranslmed.3007646
https://doi.org/10.1126/scitranslmed.3007646