Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher J. Patten"'
Autor:
Fawziah E. Almutairi, Kathrin Klein, Hongyan Sheng, David J. Greenblatt, Ulrich M. Zanger, Joanne Bourgea, Suwagmani Hazarika, Christopher J. Patten, Awewura Kwara, Michael H. Court
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4145-4152
Efavirenz is commonly used to treat patients coinfected with human immunodeficiency virus and tuberculosis. Previous clinical studies have observed paradoxically elevated efavirenz plasma concentrations in patients with the CYP2B6*6/*6 genotype (but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b46a9d57aa1bd6b6a0ff5e4107f1ee
https://doi.org/10.1128/aac.02532-14
https://doi.org/10.1128/aac.02532-14
Characterization of a Novel 'Thaw and Go' Cell‐based Transporter Model for Studying SLC Transporters
Publikováno v:
The FASEB Journal. 29
Objective: Development and characterization of a novel cell-based transporter model to study regulatory agencies (USFDA/EMA) recommended and industry important SLC transporters. Methods: Cryopreser...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e06c650b979020cd68fd83b06b2d02a3
https://doi.org/10.1096/fasebj.29.1_supplement.lb527
https://doi.org/10.1096/fasebj.29.1_supplement.lb527
Autor:
Rongjun Zuo, Sweta Parikh, Christopher J. Patten, Charles L. Crespi, Ronald A. Faris, Kirsten Cooper, Feng Li, Jin Liu, Na Li, Mercyanne Andes
Publikováno v:
The FASEB Journal. 29
Increasing evidence shows that drug transporters play an important role in drug-induced hepatotoxicity and adverse drug-drug interactions. Regulatory agencies (USFDA and EMA) recommend in their dru...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe57548db9081ab07665cbcec9192e18
https://doi.org/10.1096/fasebj.29.1_supplement.lb526
https://doi.org/10.1096/fasebj.29.1_supplement.lb526
Autor:
Christopher J. Patten
Publikováno v:
Drug Discovery Today: Technologies. 3:73-78
UDP-glucuronosyltransferases (UGT) are important hepatic xenobiotic metabolizing enzymes. As with the cytochrome P450 class of enzymes, a multiplicity of UGT forms exists in human liver and extra-hepatic tissues. The lack of a comprehensive set of UG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a31e722e4d93a4033080e5f9c84a83
https://doi.org/10.1016/j.ddtec.2006.03.007
https://doi.org/10.1016/j.ddtec.2006.03.007
Autor:
John C. L. Erve, Charles L. Crespi, Stephanie D. Turner, Andrew P. Blanchard, David M. Stresser, Christopher J. Patten, Raman Sharma, Catherine E. Cargill, Marc I. Broudy, Thuy Ho, Joseph J. Goodwin, Andre A. Dandeneau, Shangara S. Dehal
Publikováno v:
Drug Metabolism and Disposition. 32:105-112
Azamulin [14-O-(5-(2-amino-1,3,4-triazolyl)thioacetyl)-dihydromutilin] is an azole derivative of the pleuromutilin class of antiinfectives. We tested the inhibition potency of azamulin toward 18 cytochromes P450 using human liver microsomes or micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3591095bd3827c7d53a82bd20d40b4
https://doi.org/10.1124/dmd.32.1.105
https://doi.org/10.1124/dmd.32.1.105
Autor:
David J. Greenblatt, Michael H. Court, Su X. Duan, Qin Hao, Soundarajan Krishnaswamy, Christopher J. Patten, Lisa L. von Moltke
Publikováno v:
Drug Metabolism and Disposition. 31:1125-1133
UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in the glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans. The aim of this study was to identify an isoform-selective probe substrate that could be use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c28fd1d0555f8bda9341738afbe4a8
https://doi.org/10.1124/dmd.31.9.1125
https://doi.org/10.1124/dmd.31.9.1125
Autor:
Christopher J. Patten, David M. Stresser, Stephanie D. Turner, Laura Kragie, Charles L. Crespi
Publikováno v:
Endocrine Research. 28:129-140
Human aromatase (CYP19) converts C19 androgens to aromatic C18 estrogenic steroids. Its activity is critical for early and mid pregnancy maintenance and in regulating parturition in late pregnancy. Past studies have utilized placental microsome triti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ddfaf29d5374c7044ee36bfa769515
https://doi.org/10.1081/erc-120015045
https://doi.org/10.1081/erc-120015045
Autor:
Christopher J. Patten, Charles L. Crespi, Sweta Parikh, Ronald A. Faris, Jin Liu, Feng Li, Rongjun Zuo, Kirsten Cooper
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726363cb20e6009b0714b5116597188f
https://doi.org/10.1016/j.dmpk.2016.10.404
https://doi.org/10.1016/j.dmpk.2016.10.404
Autor:
Kirsten Cooper, Joanne Bourgea, Charles L. Crespi, Jie Wang, Ritu Singh, Christopher J. Patten, Na Li, Tim Creegan
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8660a0bb0d0e0681427d48d35383dfa
https://doi.org/10.1016/j.dmpk.2016.10.403
https://doi.org/10.1016/j.dmpk.2016.10.403
Autor:
Nadia Carlesso, Christopher J. Patten, Jeffrey P. Jones, Dan A. Rock, Brittany M. Weber, Shing Ming Cheng, Peter Christmas, David T. Scadden, Allan E. Rettie, Yi-Min Zheng, Roy J. Soberman
Publikováno v:
Journal of Biological Chemistry. 276:38166-38172
Diversity of cytochrome P450 function is determined by the expression of multiple genes, many of which have a high degree of identity. We report that the use of alternate exons, each coding for 48 amino acids, generates isoforms of human CYP4F3 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0489205cc0993c7a1cb7a0ea87acc7
https://doi.org/10.1074/jbc.m104818200
https://doi.org/10.1074/jbc.m104818200