Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher J. Paddon"'
Autor:
Karl J. Fisher, Robert Kinsey, Raodoh Mohamath, Tony Phan, Hong Liang, Mark T. Orr, William R. Lykins, Jeffrey A. Guderian, Julie Bakken, David Argilla, Gabi Ramer-Denisoff, Elise Larson, Yizhi Qi, Sandra Sivananthan, Karina Smolyar, Darrick Carter, Christopher J. Paddon, Christopher B. Fox
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-19 (2023)
Abstract Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One of the only unmodified animal products used in medicine is squalene, a triterpenoi
Externí odkaz:
https://doaj.org/article/1ba5dda07550439bbc3f99d9fae12512
Autor:
Emily A. Voigt, Alana Gerhardt, Derek Hanson, Madeleine F. Jennewein, Peter Battisti, Sierra Reed, Jasneet Singh, Raodoh Mohamath, Julie Bakken, Samuel Beaver, Christopher Press, Patrick Soon-Shiong, Christopher J. Paddon, Christopher B. Fox, Corey Casper
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for co
Externí odkaz:
https://doaj.org/article/b05c7356768348d7b26ac8fcef521efa
Autor:
Emily A. Voigt, Alana Gerhardt, Derek Hanson, Madeleine F. Jennewein, Peter Battisti, Sierra Reed, Jasneet Singh, Raodoh Mohamath, Julie Bakken, Samuel Beaver, Christopher Press, Patrick Soon-Shiong, Christopher J. Paddon, Christopher B. Fox, Corey Casper
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/d1865c20b9014e8295382ad0a298dfb9
Autor:
Ganesh Devidas Mahale, Subhash Singh, Brajesh Sharma, Neeraj Kumar, Ashok Kumar, Yogesh Patel, Christopher J. Paddon, Dharmendra Singh, Lavkesh Dayashankar Shri Trimurti Apt Kushwaha, Derek McPhee, Ghanshyam Maurya, Joel R. Cherry, Satinder Singh
Publikováno v:
Organic Process Research & Development. 21:551-558
The development of a cost-effective process for the production of artemisinin, the precursor of all artemisinin-derived drugs, the first-line treatment for malaria, has been a long-pursued endeavor. The breakthrough achievement of coaxing genetically
Autor:
Kirsten R. Benjamin, D. Dengrove, T. Treynor, Hanxiao Jiang, Darwin W. Reed, Karl Fisher, Douglas J. Pitera, S. Secrest, Kenneth W. Ellens, Patrick J. Westfall, M. Yu, Rika Regentin, T. Iqbal, A. Main, H. Tsuruta, Derek McPhee, Tizita Horning, R. Vazquez, S. Bajad, Ronald Henry, G. Dang, Keat H. Teoh, Jefferson C. Lievense, J. Galazzo, Scott Fickes, L. Kizer, Don Diola, Anna Tai, K. K. Reiling, B. Lieu, Patrick S. Covello, Lars F. Westblade, G. Dorin, Sara P. Gaucher, M. Fleck, Jacob R. Lenihan, M. Hepp, Michael D. Leavell, N. S. Renninger, Lishan Zhao, D. Melis, Diana Eng, Lan Xu, Jay D. Keasling, Christopher J. Paddon, Nathan A. Moss, T. Geistlinger, Jack D. Newman, Devin R Polichuk, Yansheng Zhang
Publikováno v:
Nature. 496:528-532
Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to
Autor:
Patrick J. Westfall, Derek McPhee, Christopher J. Paddon, Jack D. Newman, Douglas J. Pitera, Kirsten R. Benjamin, Karl Fisher, Michael D. Leavell, Rika Regentin, Scott Fickes
Publikováno v:
Isoprenoid Synthesis in Plants and Microorganisms ISBN: 9781461440628
Artemisinin is a sesquiterpene lactone endoperoxide with potent antimalarial properties, recommended by the World Health Organization for the treatment of malaria in artemisinin combination therapies (ACTs). It is extracted from the plant Artemisia a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2f7c395299484146814ac7e3c7bd77
https://doi.org/10.1007/978-1-4614-4063-5_7
https://doi.org/10.1007/978-1-4614-4063-5_7
Autor:
Diana Eng, Tizita Horning, Christopher J. Paddon, Larry Cameron Anthony, Jacob R. Lenihan, Jack D. Newman, Jay D. Keasling, Neil Stephen Renninger, Rika Regentin, Hiroko Tsuruta
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4489 (2009)
PloS one, vol 4, iss 2
PLoS ONE
PloS one, vol 4, iss 2
PLoS ONE
BackgroundArtemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons
Publikováno v:
Genetics. 122(3)
GCD12 encodes a translational repressor of the GCN4 protein, a transcriptional activator of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. gcd12 mutations override the requirement for the GCN2 and GCN3 gene products for derepres
Autor:
Hiroko Tsuruta, Christopher J Paddon, Diana Eng, Jacob R Lenihan, Tizita Horning, Larry C Anthony, Rika Regentin, Jay D Keasling, Neil S Renninger, Jack D Newman
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4489 (2009)
BackgroundArtemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons
Externí odkaz:
https://doaj.org/article/29329a6165654224a54f2846107a793c