Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Christopher J. Ormandy"'
Autor:
Wing-Hong Jonathan Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E. Castillo, Amanda Mawson, Moira K. O’Bryan, Christopher C. Goodnow, David Gallego-Ortega, Samantha R. Oakes, Christopher J. Ormandy
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we found a mouse with an
Externí odkaz:
https://doaj.org/article/b46a129834b748d4b3d442674bc2a867
Autor:
Andrew M. K. Law, Jiamin Chen, Yolanda Colino‐Sanguino, Laura Rodriguez de la Fuente, Guocheng Fang, Susan M. Grimes, Hongxu Lu, Robert J. Huang, Sarah T. Boyle, Jeron Venhuizen, Lesley Castillo, Javad Tavakoli, Joanna N. Skhinas, Ewan K. A. Millar, Julia Beretov, Fernando J. Rossello, Joanne L. Tipper, Christopher J. Ormandy, Michael S. Samuel, Thomas R. Cox, Luciano Martelotto, Dayong Jin, Fatima Valdes‐Mora, Hanlee P. Ji, David Gallego‐Ortega
Publikováno v:
Advanced Science, Vol 9, Iss 21, Pp n/a-n/a (2022)
Abstract To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate
Externí odkaz:
https://doaj.org/article/7c01605cf8c442bb9c5423b06b6545f3
Autor:
Laura A. Baker, Holly Holliday, Daniel Roden, Christoph Krisp, Sunny Z. Wu, Simon Junankar, Aurelien A. Serandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan, Andrew M. K. Law, Andrea McFarland, Peter T. Simpson, Sunil Lakhani, Eoin Dodson, Christina Selinger, Lyndal Anderson, Goli Samimi, Neville F. Hacker, Elgene Lim, Christopher J. Ormandy, Matthew J. Naylor, Kaylene Simpson, Iva Nikolic, Sandra O’Toole, Warren Kaplan, Mark J. Cowley, Jason S. Carroll, Mark Molloy, Alexander Swarbrick
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-18 (2020)
Abstract Background Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understanding of the molecular u
Externí odkaz:
https://doaj.org/article/afb42d75b5ee42f1b156380d241ca612
Autor:
Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z. Wu, Laura A. Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N. Skhinas, Thomas R. Cox, Bhupinder Pal, Nicholas D. Huntington, Christopher J. Ormandy, Jason S. Carroll, Jane Visvader, Mark P. Molloy, Alexander Swarbrick
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102072- (2021)
Summary: Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells; however,
Externí odkaz:
https://doaj.org/article/059b27e5f6484074bb041b8fe11c38dc
Autor:
Wee S. Teo, Holly Holliday, Nitheesh Karthikeyan, Aurélie S. Cazet, Daniel L. Roden, Kate Harvey, Christina Valbirk Konrad, Reshma Murali, Binitha Anu Varghese, Archana P. Thankamony, Chia-Ling Chan, Andrea McFarland, Simon Junankar, Sunny Ye, Jessica Yang, Iva Nikolic, Jaynish S. Shah, Laura A. Baker, Ewan K. A. Millar, Matthew J. Naylor, Christopher J. Ormandy, Sunil R. Lakhani, Warren Kaplan, Albert S. Mellick, Sandra A. O'Toole, Alexander Swarbrick, Radhika Nair
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Breast cancers display phenotypic and functional heterogeneity and several lines of evidence support the existence of cancer stem cells (CSCs) in certain breast cancers, a minor population of cells capable of tumor initiation and metastatic dissemina
Externí odkaz:
https://doaj.org/article/2535bb7b93e94bffa1b48aa93c0aa118
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Fatima Valdes-Mora, Kristina Handler, Andrew M. K. Law, Robert Salomon, Samantha R. Oakes, Christopher J. Ormandy, David Gallego-Ortega
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular matrix form the tumor microenvironment. These cancer-associated cells and components contri
Externí odkaz:
https://doaj.org/article/27903686e0c942289f8c9dfe1b98c669
Autor:
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent me
Externí odkaz:
https://doaj.org/article/df26cad288c04a3b996446d05fb3fd9a
Autor:
Elizabeth A. Musgrove, Susan J. Clark, Cristin G. Print, Robert I. Nicholson, Julia M.W. Gee, Andrew V. Biankin, Christopher J. Ormandy, C. Elizabeth Caldon, David Gallego-Ortega, C. Marcelo Sergio, Rachael A. McCloy, Fatima Valdes-Mora, Mark J. Cowley, Andrew Stone
PDF - 80KB, The effect of BI2536 in endocrine-sensitive and endocrine-resistant breast cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48de6ce62c37be717935252685c4307a
https://doi.org/10.1158/1535-7163.22499772.v1
https://doi.org/10.1158/1535-7163.22499772.v1
Autor:
Elizabeth A. Musgrove, Susan J. Clark, Cristin G. Print, Robert I. Nicholson, Julia M.W. Gee, Andrew V. Biankin, Christopher J. Ormandy, C. Elizabeth Caldon, David Gallego-Ortega, C. Marcelo Sergio, Rachael A. McCloy, Fatima Valdes-Mora, Mark J. Cowley, Andrew Stone
PDF - 221KB, A. Plk1 Expression vs relapse-free survival in endocrine treated ER-positive breast cancer patients (n=287). B. Correlative analysis of ER, BCL-2 and PLK1 gene expression in TCGA breast cohort (n=774).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017fdbbb2b1d07e283ecb30798a51fe
https://doi.org/10.1158/1535-7163.22499778.v1
https://doi.org/10.1158/1535-7163.22499778.v1