Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Christopher J. Oldfield"'
Publikováno v:
ACS Omega, Vol 5, Iss 29, Pp 17883-17891 (2020)
Externí odkaz:
https://doaj.org/article/5133fee4b3a640fd8a36d4313de99bef
Autor:
Christopher J. Oldfield, Teri L. Moffatt, Kimberley A. O'Hara, Bo Xiang, Vernon W. Dolinsky, Todd A. Duhamel
Publikováno v:
Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Abstract Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca2+ in cardiomyocytes. SERCA2a is altered by diet and ace
Externí odkaz:
https://doaj.org/article/880616f7b546467d8cd271f29449ae6b
Autor:
Ruiyang Song, Baixin Cao, Zhenling Peng, Christopher J. Oldfield, Lukasz Kurgan, Ka-Chun Wong, Jianyi Yang
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1337 (2021)
Non-synonymous single nucleotide polymorphisms (nsSNPs) may result in pathogenic changes that are associated with human diseases. Accurate prediction of these deleterious nsSNPs is in high demand. The existing predictors of deleterious nsSNPs secure
Externí odkaz:
https://doaj.org/article/abe8750b19bf4586b1b4639a08a9bb2f
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 100:361-370
Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase (SERCA) transports Ca2+ in muscle. Impaired SERCA activity may contribute to diabetic myopathy. Sirtuin (SIRT) 3 regulates muscle metabolism and function; however, it is unknown if SIRT3 regulates mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac61e1517f9e98021b5d345363f454c8
https://doi.org/10.1139/cjpp-2021-0587
https://doi.org/10.1139/cjpp-2021-0587
Autor:
Yaoqi Zhou, Andrzej Kloczkowski, Johannes Söding, Milot Mirdita, Lukasz Kurgan, Zoran Obradovic, Martin Steinegger, Akila Katuwawala, A. Keith Dunker, Jörg Gsponer, Eshel Faraggi, Bi Zhao, Christopher J. Oldfield, Nawar Malhis
Publikováno v:
Nucleic Acids Research
We present DescribePROT, the database of predicted amino acid-level descriptors of structure and function of proteins. DescribePROT delivers a comprehensive collection of 13 complementary descriptors predicted using 10 popular and accurate algorithms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5532799427c4aea84e9ae9e5cf3d8db5
http://europepmc.org/articles/PMC7778963
http://europepmc.org/articles/PMC7778963
Autor:
Wenying Yan, Fei Huang, Jianhong Zhou, Christopher J. Oldfield, A. Keith Dunker, Bairong Shen
Publikováno v:
ACS Omega, Vol 5, Iss 29, Pp 17883-17891 (2020)
ACS Omega
ICCABS
ACS Omega
ICCABS
Background: Intrinsically disordered proteins or regions (IDPs or IDRs) lack stable structures in solution, yet often fold upon binding with partners. IDPs or IDRs are highly abundant in all proteomes and represent a significant modification of seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04ada8373b26c75e5c14a6a733ff44
https://doaj.org/article/5133fee4b3a640fd8a36d4313de99bef
https://doaj.org/article/5133fee4b3a640fd8a36d4313de99bef
Autor:
Vernon W. Dolinsky, Bo Xiang, Todd A. Duhamel, Kimberley A. O'Hara, Teri L. Moffatt, Christopher J. Oldfield
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca2+ in cardiomyocytes. SERCA2a is altered by diet and acetylation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6d4889b38293d5cb979d7274a81c88
https://pubmed.ncbi.nlm.nih.gov/34405591
https://pubmed.ncbi.nlm.nih.gov/34405591
Publikováno v:
Protein Sci
The intense interest in the intrinsically disordered proteins in the life science community, together with the remarkable advancements in predictive technologies, have given rise to the development of a large number of computational predictors of int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943112244d1a54d2b52ca519157eb041
https://doi.org/10.1002/pro.3756
https://doi.org/10.1002/pro.3756
Autor:
Kanwal Kumar, Todd A. Duhamel, Olga Toleva, Christopher J. Oldfield, D. Scott Kehler, Kevin F. Boreskie, Jacqueline L. Hay, Rakesh C. Arora, Nicole M Johnston, Alexandra V Rose
Publikováno v:
Clinics in Geriatric Medicine. 35:571-585
The wait before elective cardiac intervention or surgery presents an opportunity to prevent further physiologic decline preoperatively in older patients. Implementation of prehabilitation programs decreases length of hospital stay postoperatively, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266ab1c58ed979d5beea48f491756e33
https://doi.org/10.1016/j.cger.2019.07.006
https://doi.org/10.1016/j.cger.2019.07.006
Publikováno v:
Briefings in Bioinformatics. 21:1509-1522
Experimental annotations of intrinsic disorder are available for 0.1% of 147 000 000 of currently sequenced proteins. Over 60 sequence-based disorder predictors were developed to help bridge this gap. Current benchmarks of these methods assess predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd8701104c255986d4a09874ef5018a
https://doi.org/10.1093/bib/bbz100
https://doi.org/10.1093/bib/bbz100