Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christopher J. Ochs"'
Autor:
Bruk Mensa, Iain C. Clark, Marco Mravic, Christopher J. Ochs, Adam R. Abate, Nathan W. Schmidt, Francisco J. Quintana, William F. DeGrado
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 12
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance DNA variant libraries allow unbiased analysis of sequence–function relationships. However, exhaustive combinatorial assemblies of even a modest number of parts produce libraries too large to practically screen. Library size can be redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447853e6e26db0a5cbfdd6a1f7278cea
https://doi.org/10.1073/pnas.2017719118
https://doi.org/10.1073/pnas.2017719118
Autor:
Adam R. Abate, Christopher J. Ochs
Publikováno v:
Lab on a chip, vol 15, iss 1
Single-layer membrane valves are simple to fabricate and to integrate into microfluidic devices. However, due to their rectangular flow channel geometry, they do not fully seal. Here, we show that liquid flow can be reduced by over 3 orders of magnit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dc7b2004e3688c215023a8167ba8c1
https://doi.org/10.1039/c4lc01040j
https://doi.org/10.1039/c4lc01040j
Autor:
Jonathan Hobley, Aicha Boudhar, Christopher J. Ochs, Gomathy Sandhya Subramanian, Johannes Brennecke, Dieter Trau, Martin J. Lear, Bastien Reux
Publikováno v:
Applied Surface Science. 307:475-481
Tetraphenylethene (TPE) shows a significant increase of fluorescence intensity when the rotational freedom of its phenyl groups is restricted. This special property allows the use of TPE in sensor applications, which have been previously described fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f4e6ddffb876ebd0e629f2557094df
https://doi.org/10.1016/j.apsusc.2014.04.061
https://doi.org/10.1016/j.apsusc.2014.04.061
Publikováno v:
PMC
We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dd8e5d5ffe9bb765c5cf54eaa39784
https://doi.org/10.1039/c3lc51160j
https://doi.org/10.1039/c3lc51160j
Autor:
Dieter Trau, Sebastian Beyer, Jean-Yves Dewavrin, Arjun Subramanian, Houwen Matthew Pan, Christopher J. Ochs
Publikováno v:
RSC Adv.. 4:35163-35166
Edible polyelectrolyte microcapsules are constructed from food-grade materials classified as “Generally Recognized as Safe” (GRAS). e-polylysine (EPL) and polyglutamic acid (PGA) are deposited onto water-soluble sugar–cargo mixtures by an organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a691b7b9afa74e2447654545e7c9b9
https://doi.org/10.1039/c4ra04750h
https://doi.org/10.1039/c4ra04750h
Publikováno v:
BIOspektrum. 20:773-775
A new imaging system allows visualizing oxygen distributions in 2D. Combining sensor foils with microfluidic devices enables online monitoring of cellular oxygen consumption in whole chip areas. Furthermore, suitable device materials depending on app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d233b4579cc801db667764f2a509cdb
https://doi.org/10.1007/s12268-014-0518-y
https://doi.org/10.1007/s12268-014-0518-y
Publikováno v:
ACS Nano. 4:1653-1663
We report the modular assembly of a polymer-drug conjugate into covalently stabilized, responsive, biodegradable, and drug-loaded capsules with control over drug dose and position in the multilayer film. The cancer therapeutic, doxorubicin hydrochlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609bf77d0cecec332e1813a23e3f3e81
https://doi.org/10.1021/nn9014278
https://doi.org/10.1021/nn9014278
Publikováno v:
Biomacromolecules. 9:3389-3396
We report the synthesis of covalently stabilized hollow capsules from biodegradable materials using a combination of click chemistry and layer-by-layer (LbL) assembly. The biodegradable polymers poly(L-lysine) (PLL) and poly(L-glutamic acid) (PGA) we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8abd8ecd25937592ba38a253da312
https://doi.org/10.1021/bm800794w
https://doi.org/10.1021/bm800794w
Autor:
Yi Wang, Qin Qin, Alex Y. Strongin, Roger D. Kamm, Eddie Y. Chung, Lei Lei, Christopher J. Ochs, Shaoying Lu, Andrew M. Smith, Yingxiao Wang, Ying-Xin Qi
We developed a quantum-dot-based fluorescence resonance energy transfer (QD-FRET) nanosensor to visualize the activity of matrix metalloproteinase (MT1-MMP) at cell membrane. A bended peptide with multiple motifs was engineered to position the FRET p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cffea57a0891f21237fc7ff07bcf38
https://europepmc.org/articles/PMC4675668/
https://europepmc.org/articles/PMC4675668/
Publikováno v:
Chemistry of Materials. 23:3141-3143
PGA-dopamine conjugates (PGAPDA) were synthesized and assembled onto silica particles to yield biodegradable capsules with tunable degradation properties. Increasing the dopamine content results in thicker films with a concomitant reduction in the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c23d79cf0e84eadaf0d9c11c82ede6
https://doi.org/10.1021/cm201390e
https://doi.org/10.1021/cm201390e