Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher J. Nunn"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Mitochondrial respiration is central to cellular and organismal health in eukaryotes. In baker’s yeast, however, respiration is dispensable under fermentation conditions. Because yeast are tolerant of this mitochondrial dysfunct
Externí odkaz:
https://doaj.org/article/8894275d15d549faa12a1e7a0fd51e65
Autor:
Christopher J Nunn, Sidhartha Goyal
Publikováno v:
eLife, Vol 11 (2022)
High frequencies of mutant mitochondrial DNA (mtDNA) in human cells lead to cellular defects that are associated with aging and disease. Yet much remains to be understood about the dynamics of the generation of mutant mtDNAs and their relative replic
Externí odkaz:
https://doaj.org/article/486bac0c3e7f474a8e7ae1b69d5719e8
Autor:
Christopher J. Nunn, Sidhartha Goyal
Publikováno v:
eLife. 11
High frequencies of mutant mitochondrial DNA (mtDNA) in human cells lead to cellular defects that are associated with aging and disease. Yet much remains to be understood about the dynamics of the generation of mutant mtDNAs and their relative replic
Publikováno v:
ACS synthetic biology. 10(4)
Real-time monitoring of gene expression dynamics and population levels in a multispecies microbial community could enable the study of the role of changing gene expression patterns on eco-evolutionary outcomes. Here we report the design and validatio
Autor:
Christopher J. Nunn, Damian P. Hruszkewycz, Derek I. Wozniak, Justin M. Kaplan, David C. Leitch, Iulia I. Strambeanu, Kelsey F. VanGelder, Anna L. Dunn, Graham E. Dobereiner
Publikováno v:
Organometallics. 38:85-96
The Pd-catalyzed carbonylation of cyclic β-chloro enones using simple phosphine ligands is described. Screening identified P(Me)(t-Bu)2 as the most general ligand for an array of chloro enone electrophiles. The reaction scope has been evaluated on a
Publikováno v:
Organic Process Research & Development. 22:54-61
A Design of Experiment (DoE) and kinetic screening study was carried out using an automated reaction screening platform, and as a case study, an early stage in the synthesis of a late phase developmental candidate was investigated. Key impurities wer