Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher J. Northfield"'
Autor:
Stephen Stokes, Patrick C. Mahon, Alan D. Robertson, Jalanie D’Alessandro, Paul Webb, Charles Parry, Lisa Baker, Natalia Matassova, Nicholas G. M. Davies, Sean McKenna, Andrew Massey, Rachel Parsons, Yikang Wang, Macias Alba, Paul Brough, Ben Davis, Michael Wood, Simon Bedford, Jonathan D. Moore, Christopher J. Northfield, Loic le Strat, Stephen D. Roughley, Daniel Maddox, Seema Chavda, James Brooke Murray, Allan E. Surgenor, Johannes W. G. Meissner, Terry Shaw, Heather Simmonite, Stefaniak Emma Jayne, Victoria Chell, Neil Whitehead, Kirsten Brown
Publikováno v:
Journal of medicinal chemistry. 60(6)
Libraries of nonpurified resorcinol amide derivatives were screened by surface plasmon resonance (SPR) to determine the binding dissociation constant (off-rate, kd) for compounds binding to the pyruvate dehydrogenase kinase (PDHK) enzyme. Parallel of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5f231f5660155f00b4666296b0e799
https://pubmed.ncbi.nlm.nih.gov/28199108
https://pubmed.ncbi.nlm.nih.gov/28199108
Autor:
David A. Robinson, Claire L. Nunns, Christopher J. Northfield, Jonathan D. Moore, Christine M. Richardson, Ben Davis, James Brooke Murray, Victoria Oldfield, Pawel Dokurno, Simon F. Scrace, Lisa Baker, Stuart C. Ray, Christophe Fromont, Allan E. Surgenor, Natalia Matossova, Andrew John Potter, Christopher J. Bryant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6483-6488
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb408e6192ebe8b2b837d4cc02d11d9
https://doi.org/10.1016/j.bmcl.2010.09.063
https://doi.org/10.1016/j.bmcl.2010.09.063
Autor:
Sean McKenna, Andrew Massey, Lisa Baker, K Benwell, Heather Simmonite, Teresa Brooks, Michael Wood, Stephen Stokes, Nicolas Foloppe, Andrea Fiumana, Paul Webb, Stefaniak Emma Jayne, Christopher J. Northfield, Macias Alba, Zoe Daniels, Daniel Maddox, Helen Browne, Joanne Wayne, Christopher John Graham, Stuart C. Ray
Publikováno v:
Molecular Cancer Therapeutics. 17:B163-B163
On sustaining damage to their DNA, cells employ a sophisticated mechanism of detection and repair, termed the DNA damage response (DDR). As a critical component of the DDR and G2/M checkpoint, Chk1 kinase represents an attractive target for cancer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4ad7ce30c29670a74658952948678e4
https://doi.org/10.1158/1535-7163.targ-17-b163
https://doi.org/10.1158/1535-7163.targ-17-b163
Autor:
Karen James, Ian Collins, Kathy Boxall, Brian Dymock, Paul Workman, Florence I. Raynaud, Chrisostomos Prodromou, Angela Hayes, Suzanne A. Eccles, Kwai-Ming J. Cheung, Allan E. Surgenor, Paul Webb, Martin J. Drysdale, D. Lee Walmsley, Stuart C. Ray, Allan M. Jordan, Jenifer Borgognoni, Vanessa Martins, Swee Y. Sharp, Andrea M. Lockie, Nicholas G. M. Davies, R. Howes, Lisa Wright, Thomas P. Matthews, Andrew Massey, Michael Wood, Roderick E. Hubbard, Wynne Aherne, Stephen D. Roughley, Alexandra Fink, Harry Finch, Julie E. Cansfield, Christopher J. Northfield, Paul Brough, Edward McDonald, Xavier Barril, Laurence H. Pearl
Publikováno v:
Journal of Medicinal Chemistry. 51:196-218
Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, synthesis, structure-activity relationships and pharmacokinetics of potent sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1119161a7c8a6071c66a4cc2e2330e66
https://doi.org/10.1021/jm701018h
https://doi.org/10.1021/jm701018h
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1715-1721
New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d1a7e6b148f3b2cd6a0c65bebe2052
https://doi.org/10.1039/b001569p
https://doi.org/10.1039/b001569p
Publikováno v:
Tetrahedron Letters. 40:143-146
A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baf810371875aa95f0313f224e545872
https://doi.org/10.1016/s0040-4039(98)80042-7
https://doi.org/10.1016/s0040-4039(98)80042-7
Publikováno v:
Tetrahedron Letters. 39:4905-4908
A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::256346ad0aad65cddc34e3815321054e
https://doi.org/10.1016/s0040-4039(98)00892-2
https://doi.org/10.1016/s0040-4039(98)00892-2
Publikováno v:
Tetrahedron Letters. 38:3627-3630
Condensation of 2-formylbenzoic acid with α-amino alcohol substrates proceeds with extremely high diastereoselectivity to produce tricyclic γ-lactam products. The relative stereochemistry of the major diastereoisomer has been determined by X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c592e948d2b860dc6681722eb3fd48d1
https://doi.org/10.1016/s0040-4039(97)00686-2
https://doi.org/10.1016/s0040-4039(97)00686-2
Publikováno v:
ChemInform. 29
A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd1d53817829b820a9313447bf018ab
https://doi.org/10.1002/chin.199839167
https://doi.org/10.1002/chin.199839167
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a9636242e8c10967581ccee01c62e8e
https://doi.org/10.1002/chin.199914143
https://doi.org/10.1002/chin.199914143