Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christopher J. Krueger"'
Autor:
Bingzhou Han, Yage Zhang, Xuetong Bi, Yang Zhou, Christopher J. Krueger, Xinli Hu, Zuoyan Zhu, Xiangjun Tong, Bo Zhang
Publikováno v:
Protein & Cell, Vol 12, Iss 1, Pp 39-56 (2020)
Abstract Gene expression labeling and conditional manipulation of gene function are important for elaborate dissection of gene function. However, contemporary generation of pairwise dual-function knockin alleles to achieve both conditional and geno-t
Externí odkaz:
https://doaj.org/article/bf57ec43300c4577bca79749231aea1a
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 17, Iss 2, Pp 119-128 (2019)
Chromatin conformation, localization, and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased
Externí odkaz:
https://doaj.org/article/e24729cbe2994ce7aac6317d78c9ba45
Autor:
Bingzhou Han, Yage Zhang, Yang Zhou, Biao Zhang, Christopher J. Krueger, Xuetong Bi, Zuoyan Zhu, Xiangjun Tong, Bo Zhang
Publikováno v:
Biology, Vol 11, Iss 3, p 411 (2022)
In zebrafish, RNA-guided endonucleases such as Cas9 have enabled straightforward gene knockout and the construction of reporter lines or conditional alleles via targeted knockin strategies. However, the performance of another commonly used CRISPR sys
Externí odkaz:
https://doaj.org/article/9812cb7db799470b9b8b3036a3ade4d9
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 15, Iss 5, Pp 279-286 (2017)
With numerous advancements in novel biochemical techniques, our knowledge of the role of RNAs in the regulation of cellular physiology and pathology has grown significantly over the past several decades. Nevertheless, detailed information regarding R
Externí odkaz:
https://doaj.org/article/9ae32e63922a48ef81d4b3882150b2c5
Publikováno v:
Protein & Cell, Vol 9, Iss 7, Pp 640-651 (2017)
Abstract We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag assembly at the plasma
Externí odkaz:
https://doaj.org/article/bab271869b784deb9a42e3c69975ccb7
Autor:
Mingming Chen, Zhao Ma, Xiaotian Wu, Shiqi Mao, Yantao Yang, Jie Tan, Christopher J. Krueger, Antony K. Chen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Analysis of RNA dynamics and localization at the single-molecule level in living cells has been predominantly achieved by engineering target RNAs with large insertions of tandem repeat sequences that are bound by protein-based or oligonucleo
Externí odkaz:
https://doaj.org/article/830019b1912f4a87a66e26d327bea6da
Autor:
Wen Xu, Yongxing Yang, Biying Yang, Christopher J. Krueger, Qianlin Xiao, Si Zhao, Lu Zhang, Guiting Kang, Feipeng Wang, Hongmei Yi, Wen Ren, Lu Li, Xiaoqing He, Chuanmao Zhang, Bo Zhang, Jiuran Zhao, Jinxiao Yang
Publikováno v:
Nature plants. 8(1)
The ability to manipulate the genome in a programmable manner has illuminated biology and shown promise in plant breeding. Prime editing, a versatile gene-editing approach that directly writes new genetic information into a specified DNA site without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ce5abd30926d48e5a5fd4b01cacc3e
https://pubmed.ncbi.nlm.nih.gov/34949803
https://pubmed.ncbi.nlm.nih.gov/34949803
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2166
The ability to monitor the behavior of specific genomic loci in living cells can offer tremendous opportunities for deciphering the molecular basis driving cellular physiology and disease evolution. Toward this goal, clustered regularly interspersed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbc23a11ec2ea13a2e7af093bb5f1d1c
https://pubmed.ncbi.nlm.nih.gov/32710420
https://pubmed.ncbi.nlm.nih.gov/32710420
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607114
The ability to monitor the behavior of specific genomic loci in living cells can offer tremendous opportunities for deciphering the molecular basis driving cellular physiology and disease evolution. Toward this goal, clustered regularly interspersed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a34a1901187a2bc984cda0360719203c
https://doi.org/10.1007/978-1-0716-0712-1_21
https://doi.org/10.1007/978-1-0716-0712-1_21
Autor:
Min Chen, Yiming Zhou, Nisi Zhang, Xiaolong Liang, Chuang Gao, Zhuoran Gong, Gang Bao, Christopher J. Krueger, Zhifei Dai
Publikováno v:
ACS Applied Materials & Interfaces. 10:29385-29397
Triple-negative breast cancer (TNBC) is a malignant and refractory disease with high morbidity and mortality. The TNBC shows no response to hormonal therapy nor targeted therapy due to the lack of known targetable biomarkers. Furthermore, the TNBC al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1b76957d2925b5afe5e3624ec8d4b9
https://doi.org/10.1021/acsami.8b11723
https://doi.org/10.1021/acsami.8b11723