Výsledky vyhledávání - "Christopher J. Kochansky"

Metabolite identification using an ion mobility enhanced data‐independent acquisition strategy and automated data processing

Autor: Mark Wrona, Ismael Zamora, Mark T. Cancilla, Tatiana Radchenko, Gordon Murray, Christopher J. Kochansky, Jayne Kirk, Fabien Fontaine, Russell J. Mortishire-Smith

Publikováno v: Rapid Communications in Mass Spectrometry. 34

Rationale Liquid chromatography/mass spectrometry is an essential tool for efficient and reliable quantitative and qualitative analysis and underpins much of contemporary drug metabolism and pharmacokinetics. Data-independent acquisition methods such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04ab39241b52267fdfd8609f6fbc023
https://doi.org/10.1002/rcm.8792

Zobrazit plný text záznamu

Administration of Fenofibrate Markedly ElevatesFabp3in Rat Liver and Plasma and Confounds Its Use as a Preclinical Biomarker of Cardiac and Muscle Toxicity

Autor: Michael J. Lyman, Scott Fauty, Anil P. D'mello, Christopher J. Kochansky, Katerina Vlasakova

Publikováno v: Lipids. 53:947-960

Proteins involved in lipid homeostasis are often regulated through the nuclear peroxisome proliferator-activated receptors (PPAR). PPARα is the target for the fibrate-class of drugs. Fenofibrate has been approved for its lipid-lowering effects in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469fd347f3bc59c8f6365ce5355f20a
https://doi.org/10.1002/lipd.12110

Zobrazit plný text záznamu

Decreased liver triglyceride content in adult rats exposed to protein restriction during gestation and lactation: roles of hepatic lipogenesis and lipid utilization in muscle and adipose tissue

Autor: Anil P. D'mello, Veron Browne, Claudia Mendez-Garcia, Afsana Trini, Laura Pontiggia, Christopher J. Kochansky

Publikováno v: Canadian journal of physiology and pharmacology. 97(10)

Protein restriction throughout pregnancy and lactation reduces liver triglyceride (TG) content in adult male rat offspring. The study determined the contribution of hepatic lipogenesis to the reduction in liver TG content. Rats received either contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d01328bb40eaa55191b1ceb39e05e
https://pubmed.ncbi.nlm.nih.gov/31238009

Zobrazit plný text záznamu

Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry

Autor: Andreas Brink, Christopher J. Kochansky, Tatiana Radchenko, Luca Morettoni, Alison Bateman, Fabien Fontaine, Yves Siegrist, Ismael Zamora

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0186461 (2017)

Interest in using peptide molecules as therapeutic agents due to high selectivity and efficacy is increasing within the pharmaceutical industry. However, most peptide-derived drugs cannot be administered orally because of low bioavailability and inst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af255ca576c1954c4425b0591c44ebd4
https://pubmed.ncbi.nlm.nih.gov/29995925

Zobrazit plný text záznamu

Disposition of the Dipeptidyl Peptidase 4 Inhibitor Sitagliptin in Rats and Dogs

Autor: Donald F. Hora, Suzanne L. Ciccotto, James R. Reed, Stella H. Vincent, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Ralph A. Stearns, Maria G. Beconi, Charles S. Elmore, Yohannes Teffera, Yuan-Qing Xia

Publikováno v: Drug Metabolism and Disposition. 35:525-532

The pharmacokinetics, metabolism, and excretion of sitagliptin [MK-0431; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine], a potent dipeptidyl peptidase 4 inhibitor, were eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ab689fa7f08ad97b8496dc34b69f8
https://doi.org/10.1124/dmd.106.013110

Zobrazit plný text záznamu

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability

Publikováno v: Bioorganic & Medicinal Chemistry. 14:6900-6916

Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1 position. Using these as lead compounds for further optimization, we identified sites of me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f376b03a161dd0c0e74d58d1df6a5
https://doi.org/10.1016/j.bmc.2006.06.040

Zobrazit plný text záznamu

The Role of P-glycoprotein in the Bioactivation of Raloxifene

Autor: Magang Shou, Jae H. Chang, Christopher J. Kochansky

Publikováno v: Drug Metabolism and Disposition. 34:2073-2078

Drug transporters have been shown to alter drug metabolism. Similarly, bioactivation of drugs may also be altered by drug transporters. The aim of this work was to examine the role of P-glycoprotein (Pgp) in the bioactivation of a Pgp substrate, ralo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661042c2143a61bd81187bf7991b4f04
https://doi.org/10.1124/dmd.106.012179

Zobrazit plný text záznamu

Differences in the metabolism and pharmacokinetics of two structurally similar PPAR agonists in dogs: involvement of taurine conjugation

Autor: Christopher J. Kochansky, Donald F. Hora, Sui Wang, Stella H. Vincent, K Lynn, Zhen Wang, J Brunner, Mi-Sook Kim, Zhongzhou Shen, Ronald B. Franklin

Publikováno v: Xenobiotica. 34:665-674

1. The metabolism and pharmacokinetics of two structurally similar PPAR agonists, MRL-I, (2R)-7-[3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy]-2-ethyl-3,4-dihydro-2H-benzopyran-2-carboxylic acid, and MRL-II, (2R)-7-[3-[2-chloro-4-(2,2,2,-trifluoroe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6626ae23bb403e10c7d735462bbd317d
https://doi.org/10.1080/00498250412331285445

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání