Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christopher J. Holler"'
Autor:
Meixiang Huang, Erica Modeste, Eric Dammer, Paola Merino, Georgia Taylor, Duc M. Duong, Qiudong Deng, Christopher J. Holler, Marla Gearing, Dennis Dickson, Nicholas T. Seyfried, Thomas Kukar
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-25 (2020)
Abstract Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid lipofuscinosis-11 (CLN11), a lysosome storage
Externí odkaz:
https://doaj.org/article/ddd6ed1211be478aa3e32f948993154b
Autor:
Tina L. Beckett, Dana M. Niedowicz, Christa M. Studzinski, Adam M. Weidner, Robin L. Webb, Christopher J. Holler, Rachel R. Ahmed, Harry LeVine, III, M. Paul Murphy
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 449-456 (2010)
Sporadic inclusion body myositis (sIBM) is a common age-related inflammatory myopathy characterized by the presence of intracellular inclusions that contain the amyloid-β (Aβ) peptide, a derivative of the amyloid precursor protein (APP). Aβ is bel
Externí odkaz:
https://doaj.org/article/f9fd4d5436c54d78a6f802342f23cb4e
Autor:
Jean‐François Blain, Angela Y.P. Chen, Morgan A. Brand, James C. Lanter, Christopher J. Holler, Jerusha K. Brendel, Gerhard Koenig, Duane A. Burnett, Raymond S. Hurst
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Meixiang Huang, Thomas Kukar, Paola Merino, Eric B. Dammer, Christopher J. Holler, Qiudong Deng, Nicholas T. Seyfried, Erica Modeste, Georgia L Taylor
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Helene Plun-Favreau, Daniela Melandri, Charles Arber, Jonathan D. Rohrer, Christopher J. Holler, Thomas Kukar, Marc P.M. Soutar, Adrian M. Isaacs, Selina Wray, Jackie M. Casey
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Qiudong Deng, Duc M. Duong, Thomas Kukar, Paola Merino, Georgia Taylor, Nicholas T. Seyfried, Christopher J. Holler, Dennis W. Dickson, Eric B. Dammer, Meixiang Huang, Erica Modeste, Marla Gearing
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-25 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-25 (2020)
Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid lipofuscinosis-11 (CLN11), a lysosome storage disease.
Autor:
Beatriz San Millán, Nathalie Streichenberger, Patricia J. Ward, Megan E. Merritt-Garza, Karen Jansen-West, Malú G. Tansey, Nisha Raj, Gary J. Bassell, Christopher J. Holler, María García-Murias, Leonard Petrucelli, Zhexing Wen, Koji Abe, Susana Teijeira, Jonathan D. Glass, Chongchong Xu, Anwesha Banerjee, Thomas Kukar, Brent L. Fogel, Nicholas M. Boulis, Manuel Arias, Jie Jiang, Dennis W. Dickson, Tania F. Gendron, Beatriz Quintáns, Tiffany W. Todd, María-Jesús Sobrido, Georgia Taylor, Toru Yamashita, Zachary T. McEachin, Tania García-Sobrino, Ryuichi Ohkubo, Wilfried Rossoll, Ryan H. Purcell, Chadwick M. Hales
Publikováno v:
Neuron
GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and lead to the production of aggregating dipeptide repeat proteins (DPRs) via repeat associated non-AUG (RAN) trans
Autor:
Gaurav Ghag, Georgia Taylor, Thomas Kukar, Vladimir N. Uversky, Christopher J. Holler, Vijayaraghavan Rangachari
Publikováno v:
Protein Science. 26:1759-1772
Granulins (GRNs) are a family of small (∼6 kDa) proteins generated by the proteolytic processing of their precursor, progranulin (PGRN), in many cell types. Both PGRN and GRNs are implicated in a plethora of biological functions, often in opposing
Publikováno v:
Alzheimer's & Dementia. 13
Publikováno v:
Current Enzyme Inhibition. 9:3-14