Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Christopher J. Hewitt"'
Autor:
Jelena Ochs, Mariana P. Hanga, Georgina Shaw, Niamh Duffy, Michael Kulik, Nokilaj Tissin, Daniel Reibert, Ferdinand Biermann, Panagiota Moutsatsou, Shibani Ratnayake, Alvin Nienow, Niels Koenig, Robert Schmitt, Qasim Rafiq, Christopher J. Hewitt, Frank Barry, J. Mary Murphy
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Abstract Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high‐quality, clinically‐compliant GMP cells to replace costly, high‐risk and limited sc
Externí odkaz:
https://doaj.org/article/8d664c132f564d2da30264fa84d60be3
Autor:
Mariana P. Hanga, Alvin W. Nienow, Christopher J. Hewitt, Panagiota Moutsatsou, Ivan Wall, Fritz Anthony de la Raga
Publikováno v:
Biotechnology and Bioengineering. 118:3175-3186
Cultivated meat is an emerging field, aiming to establish the production of animal tissue for human consumption in an in vitro environment, eliminating the need to raise and slaughter animals for their meat. To realise this, the expansion of primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbed4e10a319c1acb010ad63963d0c7
https://doi.org/10.1002/bit.27842
https://doi.org/10.1002/bit.27842
Autor:
Christopher J. Hewitt, Neil Bargh, Qasim A. Rafiq, John Betts, Marco Rotondi, Elena Costariol, Barney Zoro, Ned Grace, Alvin W. Nienow
Publikováno v:
Biotechnology Letters
The emergence of cell and gene therapies has generated significant interest in their clinical and commercial potential. However, these therapies are prohibitively expensive to manufacture and can require extensive time for development due to our limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f205678fabf244bcbeaf02190314be9
https://doi.org/10.1007/s10529-021-03076-3
https://doi.org/10.1007/s10529-021-03076-3
Autor:
null Jelena Ochs, null Mariana P. Hanga, null Georgina Shaw, null Niamh Duffy, null Michael Kulik, null Nokilaj Tissin, null Daniel Reibert, null Ferdinand Biermann, null Panagiota Moutsatsou, null Shibani Ratnayake, null Alvin Nienow, null Niels Koenig, null Robert Schmitt, null Qasim Rafiq, null Christopher J. Hewitt, null Frank Barry, null J. Mary Murphy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee07ab682f149b4734fc48f1d20e1b49
https://doi.org/10.1002/btm2.10387/v3/response1
https://doi.org/10.1002/btm2.10387/v3/response1
Autor:
Andrzej W. Pacek, Halina Murasiewicz, Alvin W. Nienow, Christopher J. Hewitt, Mariana P. Hanga, Karen Coopman
Publikováno v:
Journal of Chemical Technology and Biotechnology
BACKGROUND Traditional large‐scale culture systems for human mesenchymal stem/stromal cells (hMSCs) use solid microcarriers as attachment substrates. Although the use of such substrates is advantageous because of the high surface‐to‐volume rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044bdbdeabdb4883e7d503fa3e7f793c
http://europepmc.org/articles/PMC7984227
http://europepmc.org/articles/PMC7984227
Publikováno v:
Journal of Chemical Technology and Biotechnology
BACKGROUND The loss of efficiency and performance of bioprocesses on scale‐up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb198777cf231d152e1403e3f106d9c
http://europepmc.org/articles/PMC7043379
http://europepmc.org/articles/PMC7043379
Publikováno v:
Biotechnology Letters
Biotechnology letters 41(11), 1245-1253 (2019). doi:10.1007/s10529-019-02732-z
Biotechnology letters 41(11), 1245-1253 (2019). doi:10.1007/s10529-019-02732-z
Biotechnology letters 41(11), 1245-1253 (2019). doi:10.1007/s10529-019-02732-z
Published by Springer Science + Business Media B.V, Dordrecht [u.a.]
Published by Springer Science + Business Media B.V, Dordrecht [u.a.]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd492c5af3f5431ea930e9342b2ae1d7
http://europepmc.org/articles/PMC6811377
http://europepmc.org/articles/PMC6811377
Autor:
Arman Amini, Marco Rotondi, Alvin W. Nienow, Martina Micheletti, Qasim A. Rafiq, Christopher J. Hewitt, Thomas R.J. Heathman, Elena Costariol
Publikováno v:
Biotechnology and Bioengineering. 116:2488-2502
Advanced cell and gene therapies such as chimeric antigen receptor T-cell immunotherapies (CAR-T), present a novel therapeutic modality for the treatment of acute and chronic conditions including acute lymphoblastic leukaemia and non-Hodgkin lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c778f3558c04659506659a7391a17218
https://doi.org/10.1002/bit.27088
https://doi.org/10.1002/bit.27088
Autor:
Qasim A. Rafiq, Bo Kara, Karen Coopman, Alvin W. Nienow, Christopher J. Hewitt, Thomas R.J. Heathman
Publikováno v:
Biochemical Engineering Journal. 141:200-209
Human Mesenchymal Stem Cells (hMSCs) are advancing through clinical development with the first allogeneic adult hMSC therapy receiving approval in Europe. To enable successful large-scale manufacture of hMSC therapies, increased product consistency a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::842dae9be6fd968695eea95746e0ab78
https://doi.org/10.1016/j.bej.2018.10.018
https://doi.org/10.1016/j.bej.2018.10.018
Autor:
Alexey Bersenev, Marco Rotondi, Frances Verter, Alvin W. Nienow, P. Silva Couto, Qasim A. Rafiq, Christopher J. Hewitt
Publikováno v:
Biotechnology advances. 45
Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular intervention for use in cell and gene therapy (CGT) applications due to their immunomodulatory properties and multi-differentiation capability. Some of the indications wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5687b16f17781b0e1faff8de2a10387
https://pubmed.ncbi.nlm.nih.gov/32980437
https://pubmed.ncbi.nlm.nih.gov/32980437