Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christopher J. Gregg"'
Autor:
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197464 (2018)
BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first exampl
Externí odkaz:
https://doaj.org/article/424df0382778463286c9255771ab2f43
Autor:
Felix B. Pedersen, Stan Wang, Marc J. Lajoie, Verena Volf, Xavier Rios, Timothy M. Wannier, Anik Debnath, John Aach, Michael T. Laub, Devon A. Stork, Isaac D. Lutz, Gabriel T. Filsinger, Julie Zhang, Kevin Gozzi, Christopher J. Gregg, Seth L. Shipman, George M. Church, Helene M. Kuchwara
Publikováno v:
Filsinger, G T, Wannier, T M, Pedersen, F B, Lutz, I D, Zhang, J, Stork, D A, Debnath, A, Gozzi, K, Kuchwara, H, Volf, V, Wang, S, Rios, X, Gregg, C J, Lajoie, M J, Shipman, S L, Aach, J, Laub, M T & Church, G M 2021, ' Characterizing the portability of phage-encoded homologous recombination proteins ', Nature Chemical Biology, vol. 17, no. 4, pp. 394-402 . https://doi.org/10.1038/s41589-020-00710-5
Nature chemical biology
Nature chemical biology
Efficient genome editing methods are essential for biotechnology and fundamental research. Homologous recombination (HR) is the most versatile method of genome editing, but techniques that rely on host RecA-mediated pathways are inefficient and labor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce71405ae8898e68bc616a0a56a0d02
https://portal.findresearcher.sdu.dk/da/publications/a434af18-9d3d-4fe9-be6d-13d7c0ffd667
https://portal.findresearcher.sdu.dk/da/publications/a434af18-9d3d-4fe9-be6d-13d7c0ffd667
Autor:
Stan Wang, Anik Debnath, Marc J. Lajoie, Michael T. Laub, George M. Church, Helene M. Kuchwara, Verena Volf, Gabriel T. Filsinger, Julie Zhang, Kevin Gozzi, Christopher J. Gregg, Timothy M. Wannier, Felix B. Pedersen, John Aach, Devon A. Stork, Seth L. Shipman, Xavier Rios, Isaac D. Lutz
Bacterial genome editing methods are used to engineer strains for biotechnology and fundamental research. Homologous recombination (HR) is the most versatile method of genome editing, but traditional techniques using endogenous RecA-mediated pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fd0788133d9c4a0b73a158a203d7c7
Autor:
George M. Church, Csaba Pál, Xavier Rios, Christopher J. Gregg, Marc J. Lajoie, Márton Czikkely, Gabriel T. Filsinger, Helene M. Kuchwara, Timothy M. Wannier, Ákos Nyerges, Nathaniel C. Borders, David Balogh
Publikováno v:
Proc Natl Acad Sci U S A
Exploiting bacteriophage-derived homologous recombination processes has enabled precise, multiplex editing of microbial genomes and the construction of billions of customized genetic variants in a single day. The techniques that enable this, Multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7117f4f7ffa89fe8cd97e18df7a77619
https://doi.org/10.1101/2020.01.14.906594
https://doi.org/10.1101/2020.01.14.906594
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44638 (2012)
Lambda Red recombineering is a powerful technique for making targeted genetic changes in bacteria. However, many applications are limited by the frequency of recombination. Previous studies have suggested that endogenous nucleases may hinder recombin
Externí odkaz:
https://doaj.org/article/4745e1fb825c462d8a1547905ee3c89f
Autor:
Ajit Varki, Heinz Läubli, Alyssa N. Crittenden, Christopher J. Gregg, Andrea E. Bingman, Oliver M. T. Pearce, Patrick Secrest, Annie N. Samraj, Sandra Diaz, Anne K. Bergfeld, Kalyan Banda, Nissi Varki
Publikováno v:
Proceedings of the National Academy of Sciences. 112:542-547
A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of "red meat" of mammalian origin. Although multiple theories have attempted to explain this human-specific association, none have been conclus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eceb7b318760533641af7cb646c1e55b
https://doi.org/10.1073/pnas.1417508112
https://doi.org/10.1073/pnas.1417508112
Autor:
Matthieu Landon, Daniel B. Goodman, Farren J. Isaacs, Joshua A. Mosberg, Marc J. Lajoie, Oscar Vargas-Rodriguez, Michael G. Napolitano, Lakshmi Narasimhan Govindarajan, Christopher J. Gregg, Dieter Söll, George M. Church, Gleb Kuznetsov
Publikováno v:
Proceedings of the National Academy of Sciences. 113
The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as non-coding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e27d5e6cc4a4c6b3e91fa5a4e3df766
https://doi.org/10.1073/pnas.1605856113
https://doi.org/10.1073/pnas.1605856113
Publikováno v:
Journal of Biological Chemistry. 287:28852-28864
Although N-acetyl groups are common in nature, N-glycolyl groups are rare. Mammals express two major sialic acids, N-acetylneuraminic acid and N-glycolylneuraminic acid (Neu5Gc). Although humans cannot produce Neu5Gc, it is detected in the epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed612f639ebdb9acde97eb14e4dff7c9
https://doi.org/10.1074/jbc.m112.364182
https://doi.org/10.1074/jbc.m112.364182
Autor:
Hunter C. Champion, Dan E. Berkowitz, Joshua M. Hare, Daniel R. Gonzalez, Daniel Nyhan, Jochen Steppan, Alexander C. Phan, Artin A. Shoukas, Christopher J. Gregg, Lili A. Barouch
Publikováno v:
Anesthesia & Analgesia. 111:870-877
Background Emerging evidence suggests that phosphoinositide 3-kinase (PI3K) may modulate cardiac inotropy; however, the underlying mechanism remains elusive. We hypothesized that β(2)-adrenergic receptor (AR)-coupled PI3K constrains increases in car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514abf5ec657a0d540d0d7e58594e276
https://doi.org/10.1213/ane.0b013e3181ee8312
https://doi.org/10.1213/ane.0b013e3181ee8312
Autor:
Ricardo U. Sorensen, Hai Yu, Jaime Inostroza, Rachel E. Taylor, Shengshu Huang, Vered Padler-Karavani, Ajit Varki, Christopher J. Gregg, Darius Ghaderi, Victor Nizet, Xi Chen
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 207, iss 8
The Journal of experimental medicine, vol 207, iss 8
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc “xeno-autoantibody” response. Given evidence that thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebb9093c534a6589b8e50005dc1f13f
https://doi.org/10.1084/jem.20100575
https://doi.org/10.1084/jem.20100575