Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher J. Gould"'
Autor:
Daqi Tu, Yiqun Li, Hyun Kyu Song, Angela V Toms, Christopher J Gould, Scott B Ficarro, Jarrod A Marto, Bruce L Goode, Michael J Eck
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18080 (2011)
The small GTPase Rho and one of its targets, Rho-associated kinase (ROCK), participate in a variety of actin-based cellular processes including smooth muscle contraction, cell migration, and stress fiber formation. The ROCK protein consists of an N-t
Externí odkaz:
https://doaj.org/article/3e1213b7b7234af680f68a6be46937f2
Autor:
Jeffrey P. Bombardier, Richa Jaiswal, Christopher J. Gould, Bruce L. Goode, Jeff Gelles, Dennis Breitsprecher
Publikováno v:
Science. 336:1164-1168
See How They Grow Controlled assembly and disassembly of the actin cytoskeleton is essential for processes such as cell motility, cytokinesis, and tumor metastasis. The formation of new actin filaments appears to involve the protein formin paired wit
Autor:
Salvatore L. Alioto, Bruce L. Goode, Melissa Chesarone-Cataldo, Bénédicte Salin, Isabelle Sagot, Christopher J. Gould
Formins perform essential roles in actin assembly and organization in vivo, but they also require tight regulation of their activities to produce properly functioning actin structures. Saccharomyces cerevisiae Bud14 is one member of an emerging class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e770a57f53556b22e56103513a5effc
https://europepmc.org/articles/PMC4140247/
https://europepmc.org/articles/PMC4140247/
Drug resistance, either intrinsic or acquired, remains one of the primary causes of failure for cancer chemotherapy. This chapter focuses on alterations in the carrier mediated transport systems that are responsible for intrinsic and acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345769e90331c6f7cd0d14b899c244d8
https://doi.org/10.1128/9781555817572.ch36
https://doi.org/10.1128/9781555817572.ch36
Autor:
Ariana Axiaq, MBBS, Renier A.B. Visser, MBBS, Manasi Shirke, BSc, Arwa Khashkhusha, MBBS, Sara Zaidi, BSc, Raneesha Pillay, BSc, Christopher J. Goulden, BSc, Amer Harky, MRCS, MSc, Hugo Labat, Khubbaib Hasan, Marco Shiu Tsun Leung, Makishaa Nanthakumar
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 509-517 (2021)
Objectives: The UK postgraduate training program in cardiothoracic surgery is challenging and competitive, with trainees choosing the field for different reasons. This study aims to identify factors that influence medical students in pursuing a caree
Externí odkaz:
https://doaj.org/article/1ef0c4a00ebc4a9a9a230f4a0f14f545
Autor:
Timothy Cheng, BSc, Rajas Barve, BSc, Yeu Wah Michael Cheng, BSc, Andrew Ravendren, BSc, Amna Ahmed, MBBS, Steven Toh, MBBS, Christopher J. Goulden, BSc, Amer Harky, MRCS, MSc
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 418-441 (2021)
Objective: A meta-analysis of randomized controlled trials was performed to compare the effects of miniaturized extracorporeal circulation (MECC) and conventional extracorporeal circulation (CECC) on morbidity and mortality rates after cardiac surger
Externí odkaz:
https://doaj.org/article/4439cf2d27e6476882d2e7d48a5d8d9c
Publikováno v:
The Journal of Cell Biology
Bil1 binds to the regulatory sequence of Bud6, unmasking its ability to stimulate the activity of the formin Bni1 and promote actin nucleation.
Formins associate with other nucleators and nucleation-promoting factors (NPFs) to stimulate collabor
Formins associate with other nucleators and nucleation-promoting factors (NPFs) to stimulate collabor
Autor:
Olga Sokolova, Laurent Blanchoin, Alphée Michelot, Sankar Maiti, Christopher J. Gould, Bruce L. Goode
Publikováno v:
Cytoskeleton (Hoboken)
Cytoskeleton (Hoboken), 2012, 69 (6), pp.393-405. ⟨10.1002/cm.21033⟩
Cytoskeleton (Hoboken), 2012, 69 (6), pp.393-405. ⟨10.1002/cm.21033⟩
International audience; Formins are a conserved family of actin assembly-promoting factors with essential and diverse biological roles. Most of our biochemical understanding of formin effects on actin dynamics is derived from studies using formin fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72e32ebaf0fbf263195c595351d9347
https://hal.archives-ouvertes.fr/hal-00735048
https://hal.archives-ouvertes.fr/hal-00735048
Autor:
Christopher J. Gould, Laurent Blanchoin, Brian R. Graziano, Bruce L. Goode, Sankar Maiti, Alphée Michelot
Publikováno v:
Current Biology-CB
Current Biology-CB, 2011, 21 (5), pp.384-390. ⟨10.1016/j.cub.2011.01.047⟩
Current Biology-CB, Elsevier, 2011, 21 (5), pp.384-390. ⟨10.1016/j.cub.2011.01.047⟩
Current Biology-CB, 2011, 21 (5), pp.384-390. ⟨10.1016/j.cub.2011.01.047⟩
Current Biology-CB, Elsevier, 2011, 21 (5), pp.384-390. ⟨10.1016/j.cub.2011.01.047⟩
International audience; Formins are a large family of actin assembly-promoting proteins with many important biological roles [1-3]. However, it has remained unclear how formins nucleate actin polymerization. All other nucleators are known to recruit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac1fae137165453a155b406c34b5462
https://europepmc.org/articles/PMC3058777/
https://europepmc.org/articles/PMC3058777/
Publikováno v:
Developmental cell. 16(2)
Summary Normal cellular development and function require tight spatiotemporal control of actin assembly. Formins are potent actin assembly factors that protect the growing ends of actin filaments from capping proteins. However, it is unresolved how t