Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christopher J. Farady"'
Autor:
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B. Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J. Farady, Simón Méndez-Ferrer, Radek C. Skoda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Inflammatory cytokines are elevated in patients with myeloproliferative neoplasms (MPN). Here the authors show that the JAK2-V617F mutation is associated with increased expression of IL-1 in MPN patients and that loss of IL-1β in JAK2-V617F mutant h
Externí odkaz:
https://doaj.org/article/9e49c6b3c0a84551bf6d7fb1d605c39b
Autor:
Diane Heiser, Joëlle Rubert, Adeline Unterreiner, Claudine Maurer, Marion Kamke, Ursula Bodendorf, Christopher J. Farady, Ben Roediger, Frédéric Bornancin
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions. Protein kinase D
Externí odkaz:
https://doaj.org/article/b34f9244fab24b9282945afea3cea706
Autor:
Shivam Rai, Yang Zhang, Elodie Grockowiak, Quentin Kimmerlin, Nils Hansen, Cedric B. Stoll, Marc Usart, Hui Hao-Shen, Michael S. Bader, Jakob R. Passweg, Stefan Dirnhofer, Christopher J. Farady, Timm Schroeder, Simón Méndez-Ferrer, Radek C. Skoda
JAK2-V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). However,JAK2-V617F can also be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much higher than the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14733e1fc258e0cbd8402d7f500276c2
https://doi.org/10.1101/2023.05.21.541610
https://doi.org/10.1101/2023.05.21.541610
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
Supplementary Figure 4 from Tumor Detection by Imaging Proteolytic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48840cf50c26f0a84ae789161a92f4f8
https://doi.org/10.1158/0008-5472.22386572
https://doi.org/10.1158/0008-5472.22386572
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
Supplementary Figure 2 from Tumor Detection by Imaging Proteolytic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d333cbf685b218f0922b1f6ef2b21c1
https://doi.org/10.1158/0008-5472.22386578.v1
https://doi.org/10.1158/0008-5472.22386578.v1
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
Supplementary Figure 1 from Tumor Detection by Imaging Proteolytic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5475715bde4fb5a501ff071109d487bd
https://doi.org/10.1158/0008-5472.22386581.v1
https://doi.org/10.1158/0008-5472.22386581.v1
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
The cell surface protease membrane-type serine protease-1 (MT-SP1), also known as matriptase, is often upregulated in epithelial cancers. We hypothesized that dysregulation of MT-SP1 with regard to its cognate inhibitor hepatocyte growth factor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1807888727f30a3cefa6c3ce9ddf2fa
https://doi.org/10.1158/0008-5472.c.6501575
https://doi.org/10.1158/0008-5472.c.6501575
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Autor:
Andreas Boettcher, Adeline Unterreiner, Muriel Kauffmann, Christopher J. Farady, Jörg Eder, Alice Fruhauf, Ursula Bodendorf, Joëlle Rubert, Diane Heiser, Achim Schlapbach, Frédéric Bornancin, P. Erbel
Publikováno v:
Biochemical and Biophysical Research Communications. 545:177-182
The NLRP3 inflammasome is a critical component of the innate immune response to sterile inflammation. Its regulation involves a priming step, required for up-regulation of inflammasome protagonists and an activation step leading to NLRP3 inflammasome
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Anna Kostina, Svenja Wöhrle, Stephan Flemming, Larissa Fischer, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian Parker, Andreas Boettcher, Christopher J. Farady, Rolf Backofen, Marta Rodriguez-Franco, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Inflammasomes are intracellular protein complexes that control proteolytic maturation and secretion of inflammatory interleukin-1 (IL-1) family cytokines and are thus important in host defense. While some inflammasomes are activated simply by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91918a639a74468417a76d5d58c4b680
https://doi.org/10.1101/2022.02.19.480941
https://doi.org/10.1101/2022.02.19.480941