Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher J. Dougherty"'
Effective virus inactivation and removal by steps of Biotest Pharmaceuticals IGIV production process
Autor:
Christopher J. Dougherty, Eckhard Flechsig, Michael Kretschmar, Herbert O. Dichtelmüller, Frank Sananes
Publikováno v:
Results in Immunology
The virus validation of three steps of Biotest Pharmaceuticals IGIV production process is described here. The steps validated are precipitation and removal of fraction III of the cold ethanol fractionation process, solvent/detergent treatment and 35n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5079ed0f6e49093ef1d407e265a8ae74
Autor:
Lori A. Kubasiak, Christopher J. Dougherty, Nanette H. Bishopric, Donna P. Frazier, Keith A. Webster, Wen Cheng Xiong, Huifang Li
Publikováno v:
The FASEB Journal. 18:1060-1070
C-Jun N-terminal kinase (JNK) is part of the mitogen-activated protein kinase (MAPK) family of signaling pathways that are induced in response to extracellular stimuli. JNK is primarily a stress-response pathway and can be activated by proinflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f13ec68c92ee97ffa24e5a10d162c85
https://doi.org/10.1096/fj.04-1505com
https://doi.org/10.1096/fj.04-1505com
Autor:
Christopher J. DOUGHERTY, Lori A. KUBASIAK, Howard PRENTICE, Peter ANDREKA, Nanette H. BISHOPRIC, Keith A. WEBSTER
Publikováno v:
Biochemical Journal. 362:561-571
Reperfusion injury occurs when ischaemic tissue is reperfused. It involves the generation and release of reactive oxygen that activates numerous signalling pathways and initiates cell death. Exposure of isolated cardiac myocytes to chronic hypoxia fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ce27bae240391c8fe07a47058ee8033
https://doi.org/10.1042/bj3620561
https://doi.org/10.1042/bj3620561
Autor:
Keith A. Webster, Tatiana I. Slepak, Christopher J. Dougherty, Jie Zang, Nanette H. Bishopric, Péter Andréka
Publikováno v:
Circulation Research. 88:305-312
Abstract —Nitric oxide (NO) induces apoptosis in cardiac myocytes through an oxidant-sensitive mechanism. However, additional factors appear to modulate the exact timing and rate of NO-dependent apoptosis. In this study, we investigated the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb60c48d23dc8b155612601c66403b0
https://doi.org/10.1161/01.res.88.3.305
https://doi.org/10.1161/01.res.88.3.305
Publikováno v:
Infection
An available supply of intravenous immunoglobulin (IVIG) is essential for individuals with primary humoral immunodeficiency. A shortage in 1997 prompted the Food and Drug Administration (FDA) to revise guidelines for the licensure, production, and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59934c7f541c6d7fe7867350189bafd0
https://pubmed.ncbi.nlm.nih.gov/22968971
https://pubmed.ncbi.nlm.nih.gov/22968971
Autor:
Huilan Wang, Keith A. Webster, Ines Chopra, Nikhil Adi, Weiwen Wang, Christopher J. Dougherty, Jennipher Adi, Jianqin Wei, Huifang Li
Brief periods of ischemia do not damage the heart and can actually protect against reperfusion injury caused by extended ischemia. It is not known what causes the transition from protection to irreversible damage as ischemia progresses. c-Jun N-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf26fa56a8ad0be9e2c8ba532e1a335
https://europepmc.org/articles/PMC3077600/
https://europepmc.org/articles/PMC3077600/
Autor:
Janet C. Blanks, Michele Nachman-Clewner, Christopher J. Dougherty, Loan Dang, Robert H. I. Blanks, Frank J. Giblin, C. Kathleen Dorey
Publikováno v:
Investigative ophthalmologyvisual science. 49(7)
PURPOSE. Metallothioneins (MTs) in the brain and retina are believed to bind metals and reduce free radicals, thereby protecting neurons from oxidative damage. This study was undertaken to investigate whether retinal photoreceptor (PR) cells lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c47757b43a999becc3816b27480a2a
https://pubmed.ncbi.nlm.nih.gov/18579766
https://pubmed.ncbi.nlm.nih.gov/18579766
Autor:
Wei-Ping Min, Gary Reznik, Thomas E. Ichim, Boris N. Reznik, Christopher J. Dougherty, Liping Liu, Anahit Ghochikyan, Michael G. Agadjanyan
Publikováno v:
Biochemical and biophysical research communications. 370(1)
Brother of the regulator of imprinted sites (BORIS) is an epigenetically acting transcription factor which represses the tumor inhibitor functions of the tumor suppressor protein CTCF. BORIS expression has not been documented in adult females, making
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58943705ab912deb4a7ead9008b14c87
https://pubmed.ncbi.nlm.nih.gov/18355444
https://pubmed.ncbi.nlm.nih.gov/18355444
Autor:
I.A. Moench, Keith A. Webster, Howard Prentice, Christopher J. Dougherty, Z.T. Rickaway, Herbert Weissbach
Publikováno v:
Biochemical and biophysical research communications. 366(3)
Reactive oxygen species (ROS) are critical in tissue responses to ischemia-reperfusion. The enzyme methionine sulfoxide reductase-A (MsrA) is capable of protecting cells against oxidative damage by reversing damage to proteins caused by methionine ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe6407b2b6ac34439a6613870a6b785
https://pubmed.ncbi.nlm.nih.gov/18083115
https://pubmed.ncbi.nlm.nih.gov/18083115
Publikováno v:
Circulation. 116
Loss of pericytes is a critical event early in the progression of microvascular dysfunction in diabetic retinopathy. Pericyte loss may be linked to high glucose mediated reactive oxygen species generation, blocking N-cadherin trafficking to the endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed46f66da2bac47b756197f0412d781
https://doi.org/10.1161/circ.116.suppl_16.ii_26-c
https://doi.org/10.1161/circ.116.suppl_16.ii_26-c