Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christopher J. Dionne"'
Autor:
Ellen V. Rothenberg, Christopher J. Dionne, Christopher B. Franco, Kevin Y. Tse, Michele K. Anderson, Angela H. Weiss, David L. Wiest
Publikováno v:
Developmental Biology. 280:448-466
Specification of mammalian T lymphocytes involves prolonged developmental plasticity even after lineage-specific gene expression begins. Expression of transcription factor PU.1 may maintain some myeloid-like developmental alternatives until commitmen
Publikováno v:
Immunological Reviews. 187:96-115
The earliest stages of intrathymic T-cell development include not only the acquisition of T-cell characteristics but also programmed loss of potentials for B, natural killer, and dendritic cell development. Evidence from genetics and cell-transfer st
Publikováno v:
Immunological reviews. 187
The earliest stages of intrathymic T-cell development include not only the acquisition of T-cell characteristics but also programmed loss of potentials for B, natural killer, and dendritic cell development. Evidence from genetics and cell-transfer st
Autor:
Michele K. Anderson, Dan Chen, Christopher J. Dionne, Alexandra M. Arias, Ellen V. Rothenberg, Gabriela Hernandez-Hoyos
Publikováno v:
Developmental biology. 246(1)
PU.1 and GATA-3 are transcription factors that are required for development of T cell progenitors from the earliest stages. Neither one is a simple positive regulator for T lineage specification, however. When expressed at elevated levels at early st
Autor:
Christopher J. Dionne, Angela H. Weiss, Ellen V. Rothenberg, Michele K. Anderson, Gabriela Hernandez-Hoyos
Publikováno v:
Immunity. (2):285-296
The essential hematopoietic transcription factor PU.1 is expressed in multipotent thymic precursors but downregulated during T lineage commitment. The significance of PU.1 downregulation was tested using retroviral vectors to force hematopoietic prec