Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher J. Bley"'
Publikováno v:
Cold Spring Harbor perspectives in biology. 14(12)
The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a double membrane continuous with the endoplasmic reticulum. The nuclear pore complex (NPC) is an ∼110-MDa, ∼1000-protein channel that selectively transports macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5a2cc02a0c4ef9fab235277724990e
https://pubmed.ncbi.nlm.nih.gov/36096637
https://pubmed.ncbi.nlm.nih.gov/36096637
Autor:
Stefan Petrovic, Dipanjan Samanta, Thibaud Perriches, Christopher J. Bley, Karsten Thierbach, Bonnie Brown, Si Nie, George W. Mobbs, Taylor A. Stevens, Xiaoyu Liu, Giovani Pinton Tomaleri, Lucas Schaus, André Hoelz
Publikováno v:
Science
INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC). Embedded in nuclear envelope pores, the ~110-MDa human NPC is an ~1200-Å-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05f53a74a72b4d8ed0c06189ff80ea9
https://doi.org/10.1126/science.abm9798
https://doi.org/10.1126/science.abm9798
Autor:
Christopher J. Bley, Si Nie, George W. Mobbs, Stefan Petrovic, Anna T. Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M. Huber, Daniel H. Lin, Bonnie Brown, Aaron W. Tang, Emily J. Rundlet, Ana R. Correia, Shane Chen, Saroj G. Regmi, Taylor A. Stevens, Claudia A. Jette, Mary Dasso, Alina Patke, Alexander F. Palazzo, Anthony A. Kossiakoff, André Hoelz
Publikováno v:
Science (New York, N.Y.). 376(6598)
INTRODUCTIONThe subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein–nucleic acid complexes. Embedded in nuclear envelope pores, which are generated by the circumscribed fusion of the inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d66691a34cb3dd35cafaab2561b734
https://pubmed.ncbi.nlm.nih.gov/35679398
https://pubmed.ncbi.nlm.nih.gov/35679398
Autor:
André Hoelz, Thibaud Perriches, George W. Mobbs, Christopher J. Bley, Karsten Thierbach, Stefan Petrovic, Taylor A. Stevens, Xiaoyu Liu, Bonnie Brown, Dipanjan Samanta, Si Nie
The nuclear pore complex (NPC) is the sole bidirectional gateway for nucleocytoplasmic transport. Despite recent progress in elucidating the arrangement of the structured scaffold building blocks in the NPC symmetric core, their cohesion by multivale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79903593e00cb1f80fb9a3cddd85a6e1
https://doi.org/10.1101/2021.10.26.465796
https://doi.org/10.1101/2021.10.26.465796
Autor:
Anthony A. Kossiakoff, Ferdinand M. Huber, Mary Dasso, Emily J. Rundlet, Saroj G. Regmi, Anna T. Gres, Alina Patke, Alexander F. Palazzo, George W. Mobbs, Daniel H. Lin, Somnath Mukherjee, Sho Harvey, Christopher J. Bley, Xiaoyu Liu, André Hoelz, Bonnie Brown, Ana R. Correia, Aaron W. Tang, Stefan Petrovic, Shane Chen, Si Nie
The nuclear pore complex (NPC) is the sole bidirectional gateway for nucleocytoplasmic transport. Despite recent progress in elucidating the NPC symmetric core architecture, the asymmetrically decorated cytoplasmic face, essential for mRNA export and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6421e1976bd726cc0e8c631f4edd780c
https://doi.org/10.1101/2021.10.26.465790
https://doi.org/10.1101/2021.10.26.465790
Autor:
Daniel J. Mayo, Young E. Jeon, Stefan Petrovic, Marcin Paduch, Ed Hurt, Vincent Lu, Leslie N. Collins, Christopher J. Bley, Tobias Stuwe, André Hoelz, Jessica Fischer, Daniel H. Lin, Sandra Schilbach, Akiko Koide, Shohei Koide, Anthony A. Kossiakoff, Ferdinand M. Huber, Thibaud Perriches, Emily J. Rundlet, Karsten Thierbach
Publikováno v:
Science. 350:56-64
Building a gate to the nucleus Nuclear pore complexes form a gateway between the cytoplasm and the nucleus (see the Perspective by Ullman and Powers). Stuwe et al. combined structural, biochemical, and functional analyses to elucidate the architectur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2636ad106ac16299ec859f3e45c97d3
https://doi.org/10.1126/science.aac9176
https://doi.org/10.1126/science.aac9176
Publikováno v:
Bio-protocol. 5(16)
Telomerase is a large ribonucleoprotein complex that replicates the linear chromosome ends in most eukaryotes. Large-scale preparation of the telomerase core components in vitro has long been a big challenge in this field, hindering the understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bba76ab0a479cb8de8601201f946275
https://pubmed.ncbi.nlm.nih.gov/29104888
https://pubmed.ncbi.nlm.nih.gov/29104888
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1587
Telomerase is a unique reverse transcriptase that replicates the telomeric DNA at most eukaryotic chromosomal ends. The telomerase consists of the catalytic protein subunit TERT and the RNA component TR that provides the template for telomeric DNA sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b92e9203d5d841f7111de0ebcebd2d3
https://pubmed.ncbi.nlm.nih.gov/28324508
https://pubmed.ncbi.nlm.nih.gov/28324508
Publikováno v:
Telomeres and Telomerase ISBN: 9781493968916
Telomerase is a unique reverse transcriptase that replicates the telomeric DNA at most eukaryotic chromosomal ends. The telomerase consists of the catalytic protein subunit TERT and the RNA component TR that provides the template for telomeric DNA sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40cfb095f3950f4763f13e245413b85
https://doi.org/10.1007/978-1-4939-6892-3_16
https://doi.org/10.1007/978-1-4939-6892-3_16
Autor:
Christopher J. Bley, Randall W. Nelson, Julian J.-L. Chen, Chad R. Borges, Dustin P. Rand, Xiaodong Qi
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20333-20338
Telomerase is a specialized reverse transcriptase containing an intrinsic telomerase RNA (TR) which provides the template for telomeric DNA synthesis. Distinct from conventional reverse transcriptases, telomerase has evolved a unique TR-binding domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017c00314cefc49e53daee607294aa8d
https://doi.org/10.1073/pnas.1100270108
https://doi.org/10.1073/pnas.1100270108