Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christopher J. Benway"'
Autor:
Seong Kyu Han, Michelle T. McNulty, Christopher J. Benway, Pei Wen, Anya Greenberg, Ana C. Onuchic-Whitford, Nephrotic Syndrome Study Network (NEPTUNE), Dongkeun Jang, Jason Flannick, Noël P. Burtt, Parker C. Wilson, Benjamin D. Humphreys, Xiaoquan Wen, Zhe Han, Dongwon Lee, Matthew G. Sampson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are ongo
Externí odkaz:
https://doaj.org/article/7d29a604d3e4432e9d83b826b3e053bc
Autor:
Josée Dupuis, Victoria E. Jackson, Hanfei Xu, Brian D. Hobbs, Edwin K. Silverman, Michael H. Cho, Megan L. Grove, Jennifer N. Nguyen, Jiangyuan Liu, George T. O'Connor, Natalie Terzikhan, Ani Manichaikul, Patricia A. Cassano, Colleen M. Sitlani, Buhm Han, Ian P. Hall, Bing Yu, Sina A. Gharib, Lies Lahousse, Louise V. Wain, Traci M. Bartz, Christopher J. Benway, R. Graham Barr, Phuwanat Sakornsakolpat, Guy Brusselle, Stephanie J. London, Kun Hee Kim, Martin D. Tobin, Matthew Moll, Jinkyeong Park, Woo Jin Kim, Bonnie K Patchen, Stephen S. Rich
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L130-L143. American Physiological Society
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L130-L143. American Physiological Society
Genome-wide association studies (GWASs) have identified regions associated with chronic obstructive pulmonary disease (COPD). GWASs of other diseases have shown an approximately 10-fold overrepresentation of nonsynonymous variants, despite limited ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cb68b992b8fdd29d75b61efee547b4
https://doi.org/10.1152/AJPLUNG.00009.2021
https://doi.org/10.1152/AJPLUNG.00009.2021
Autor:
Xiaobo Zhou, Scott H. Randell, Fei Du, Feng Guo, Edwin K. Silverman, Christopher J. Benway, Michael H. Cho, Jiangyuan Liu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Genome-wide association studies (GWASs) have identified dozens of loci associated with risk of chronic obstructive pulmonary disease (COPD). However, identifying the causal variants and their functional role in the appropriate cell type remains a maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248218dfd96e26000f094c44309cc51f
https://doi.org/10.1165/rcmb.2020-0475oc
https://doi.org/10.1165/rcmb.2020-0475oc
Autor:
Sharon M. Lutz, Craig P. Hersh, Julian Hecker, Brian D. Hobbs, John E. Hokanson, Dawn L. DeMeo, Michael H. Cho, Edwin K. Silverman, Christoph Lange, Peter J. Castaldi, Russell P. Bowler, Christopher J. Benway, Terri H. Beaty, James D. Crapo, M.F. Ragland
Publikováno v:
Am J Respir Crit Care Med
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d606267692cc6b77eb0bea12a704426
https://doi.org/10.1164/rccm.201808-1455so
https://doi.org/10.1164/rccm.201808-1455so
Autor:
Feng Guo, Jin-Ah Park, Samuel Bates, Fei Du, Christopher J. Benway, Xiaobo Zhou, Jiangyuan Liu, Michael H. Cho, Lu Gong, Craig P. Hersh, Peter J. Castaldi, Hongmei Mou, Yuan Hao, Betty Pham, Jarrett D. Morrow, Weiliang Qiu, Jeong H. Yun, Yihan Zhang, Ivan O. Rosas
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Genetic association studies have identified rs2076295 in association with idiopathic pulmonary fibrosis (IPF). We hypothesized that rs2076295 is the functional variant regulating DSP (de...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5508dcdb8ecf33ff67cafac8a23377
https://pubmed.ncbi.nlm.nih.gov/32716632
https://pubmed.ncbi.nlm.nih.gov/32716632
Autor:
Katherine E, Lowe, Elizabeth A, Regan, Antonio, Anzueto, Erin, Austin, John H M, Austin, Terri H, Beaty, Panayiotis V, Benos, Christopher J, Benway, Surya P, Bhatt, Eugene R, Bleecker, Sandeep, Bodduluri, Jessica, Bon, Aladin M, Boriek, Adel Re, Boueiz, Russell P, Bowler, Matthew, Budoff, Richard, Casaburi, Peter J, Castaldi, Jean-Paul, Charbonnier, Michael H, Cho, Alejandro, Comellas, Douglas, Conrad, Corinne, Costa Davis, Gerard J, Criner, Douglas, Curran-Everett, Jeffrey L, Curtis, Dawn L, DeMeo, Alejandro A, Diaz, Mark T, Dransfield, Jennifer G, Dy, Ashraf, Fawzy, Margaret, Fleming, Eric L, Flenaugh, Marilyn G, Foreman, Spyridon, Fortis, Hirut, Gebrekristos, Sarah, Grant, Philippe A, Grenier, Tian, Gu, Abhya, Gupta, MeiLan K, Han, Nicola A, Hanania, Nadia N, Hansel, Lystra P, Hayden, Craig P, Hersh, Brian D, Hobbs, Eric A, Hoffman, James C, Hogg, John E, Hokanson, Karin F, Hoth, Albert, Hsiao, Stephen, Humphries, Kathleen, Jacobs, Francine L, Jacobson, Ella A, Kazerooni, Victor, Kim, Woo Jin, Kim, Gregory L, Kinney, Harald, Koegler, Sharon M, Lutz, David A, Lynch, Neil R, MacIntye, Barry J, Make, Nathaniel, Marchetti, Fernando J, Martinez, Diego J, Maselli, Anne M, Mathews, Meredith C, McCormack, Merry-Lynn N, McDonald, Charlene E, McEvoy, Matthew, Moll, Sarah S, Molye, Susan, Murray, Hrudaya, Nath, John D, Newell, Mariaelena, Occhipinti, Matteo, Paoletti, Trisha, Parekh, Massimo, Pistolesi, Katherine A, Pratte, Nirupama, Putcha, Margaret, Ragland, Joseph M, Reinhardt, Stephen I, Rennard, Richard A, Rosiello, James C, Ross, Harry B, Rossiter, Ingo, Ruczinski, Raul, San Jose Estepar, Frank C, Sciurba, Jessica C, Sieren, Harjinder, Singh, Xavier, Soler, Robert M, Steiner, Matthew J, Strand, William W, Stringer, Ruth, Tal-Singer, Byron, Thomashow, Gonzalo, Vegas Sánchez-Ferrero, John W, Walsh, Emily S, Wan, George R, Washko, J, Michael Wells, Chris H, Wendt, Gloria, Westney, Ava, Wilson, Robert A, Wise, Andrew, Yen, Kendra, Young, Jeong, Yun, Edwin K, Silverman, James D, Crapo
Publikováno v:
Chronic obstructive pulmonary diseases (Miami, Fla.). 6(5)
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62e4d02722f11d3899cb483a5d84ec66
https://pubmed.ncbi.nlm.nih.gov/31710793
https://pubmed.ncbi.nlm.nih.gov/31710793
Autor:
Christopher J. Benway, E.K. Silverman, Phuwanat Sakornsakolpat, Brian D. Hobbs, Michael H. Cho, James C. Ross
Publikováno v:
D29. LUNG MULTI-OMICS TO MECHANISM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b165fcf9614067c1f5f210f0b50da20
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6091
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6091
Autor:
Harry B. Rossiter, Spyridon Fortis, Panayiotis V. Benos, Andrew Yen, Woo Jin Kim, John W. Walsh, John D. Newell, Jessica C. Sieren, Gloria Westney, Margaret Fleming, Katherine E Lowe, William W. Stringer, Gonzalo Vegas Sanchez-Ferrero, Hirut T. Gebrekristos, Marilyn G. Foreman, M.F. Ragland, Barry J. Make, Trisha M. Parekh, Hrudaya Nath, Harjinder Singh, Raúl San José Estépar, Francine L. Jacobson, Jeffrey L. Curtis, Karin F. Hoth, Matthew J. Budoff, Kathleen Jacobs, Stephen M. Humphries, Victor Kim, Lystra P. Hayden, Robert A. Wise, Philippe Grenier, Diego J. Maselli, Neil R. MacIntye, Michael H. Cho, Gregory L. Kinney, Nathaniel Marchetti, Stephen I. Rennard, Russell P. Bowler, MeiLan K. Han, J. Michael Wells, Eric Flenaugh, Abhya Gupta, Christopher J. Benway, Nirupama Putcha, Brian D. Hobbs, Matthew Moll, Mark T. Dransfield, Eric A. Hoffman, Jennifer G. Dy, James C. Hogg, Charlene McEvoy, Anne M. Mathews, Antonio Anzueto, James C. Ross, Harald Koegler, Erin Austin, Chris H. Wendt, Peter J. Castaldi, John E. Hokanson, Frank C. Sciurba, Xavier Soler, Surya P. Bhatt, Craig P. Hersh, George R. Washko, Gerard J. Criner, Corinne Costa Davis, Sharon M. Lutz, Mariaelena Occhipinti, Douglas Conrad, Jessica Bon, Elizabeth A. Regan, Joseph M. Reinhardt, Dawn L. DeMeo, Emily S. Wan, Kendra A. Young, Byron Thomashow, Meredith C. McCormack, Ingo Ruczinski, Sandeep Bodduluri, Douglas Curran-Everett, Matteo Paoletti, Katherine A. Pratte, Robert M. Steiner, Merry-Lynn McDonald, Edwin K. Silverman, Tian Gu, Massimo Pistolesi, Sarah Schmidt Grant, Aladin M. Boriek, David A. Lynch, Alejandro A. Diaz, Ruth Tal-Singer, Ava C. Wilson, Adel Boueiz, Terri H. Beaty, James D. Crapo, Eugene R. Bleecker, Alejandro P. Comellas, Ashraf Fawzy, Susan Murray, Albert Hsiao, Nadia N. Hansel, John H. M. Austin, Jeong H. Yun, Sarah S. Molye, Richard Casaburi, Ella A. Kazerooni, Jean-Paul Charbonnier, Richard Rosiello, Fernando J. Martinez, Matthew Strand, Nicola A. Hanania
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5cc3900bf1718c84260395c7b870f6
http://hdl.handle.net/2158/1193313
http://hdl.handle.net/2158/1193313
Publikováno v:
American Journal of Transplantation. 15:1682-1691
A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. In this study, we examined whether microRNAs play a role in cyclosporine-induced nephrotoxicity. Treatment of mice with CsA resulted in nephrotoxicity that was assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14510b4d7844f968291d2f31b7a34603
https://doi.org/10.1111/ajt.13161
https://doi.org/10.1111/ajt.13161
Autor:
John Iacomini, Christopher J. Benway
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 18(4)
Calcineurin inhibitors induce nephrotoxicity through poorly understood mechanisms thereby limiting their use in transplantation and other diseases. Here we define a microRNA (miRNA)-messenger RNA (mRNA) interaction map that facilitates exploration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef38bf8564c8b9f9177c1b14a379d9a1
https://pubmed.ncbi.nlm.nih.gov/28925592
https://pubmed.ncbi.nlm.nih.gov/28925592