Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Christopher J. Bagley"'
Publikováno v:
Proteome Science
Proteomic matrix-assisted laser desorption/ionisation (MALDI) linear time-of-flight (TOF) mass spectrometry (MS) may be used to produce protein profiles from biological samples with the aim of discovering biomarkers for disease. However, the raw prot
Autor:
Peter Hoffmann, Mark R. Condina, Manuela Klingler-Hoffmann, Shaun R. McColl, Johan O. R. Gustafsson, Christopher J. Bagley
Publikováno v:
PROTEOMICS. 10:2516-2530
The quality of MALDI-TOF mass spectrometric analysis is highly dependent on the matrix and its deposition strategy Although different matrix-deposition methods have specific advantages, one major problem in the field of proteomics, particularly with
Autor:
Roberto Cappai, William J. McKinstry, Gabriela A. N. Crespi, Kevin J. Barnham, Kwok S. Wun, Michelle T. Fodero-Tavoletti, Denise Galatis, Luke A. Miles, Christopher J. Bagley, Colin L. Masters, Michael W. Parker, Konrad Beyreuther
Publikováno v:
Journal of Molecular Biology. 377:181-192
Alzheimer's disease (AD) is the most common form of dementia. Amyloid-beta (A beta) peptide, generated by proteolytic cleavage of the amyloid precursor protein, is central to AD pathogenesis. Most pharmaceutical activity in AD research has focused on
Autor:
Roberto Romero, Jui T. Ho, John G. Lewis, Christopher J. Bagley, Gus A. Dekker, Peter D. O’Loughlin, David J. Torpy
Publikováno v:
Clinical Endocrinology. 66:869-877
OBJECTIVE To measure and contrast maternal cortisol and corticosteroid-binding globulin (CBG) levels in pregnancies with normal outcomes, pre-eclampsia, intrauterine growth restriction (IUGR) and in gamete recipients. STUDY DESIGN Prospective study o
Autor:
T. Quach, John G. Lewis, J. T. Ho, Marianne J. Chapman, David J. Torpy, H. Al-Musalhi, P. Thomas, Christopher J. Bagley
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:105-114
Severe systemic infection leads to hypercortisolism. Reduced cortisol binding proteins may accentuate the free cortisol elevations seen in systemic infection. Recently, low total cortisol increments after tetracosactrin have been associated with incr
Autor:
Angel F. Lopez, Joanna M. Woodcock, Christopher J. Bagley, Timothy Robert Hercus, Geoff J. Howlett, Barbara J. McClure, Bronwyn Cambareri
Publikováno v:
Blood. 101:1308-1315
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that stimulates the production and functional activity of granulocytes and macrophages, properties that have encouraged its clinical use in bone marrow transplantat
Autor:
Reza Zareie, Paul A.B. Moretti, Richard J D'Andrea, Andrew L. Darrow, Mathew A. Vadas, Stuart M. Pitson, Julia R. Zebol, Binks W. Wattenberg, Christopher J. Bagley, Claudia K. Derian, Jenson Qi
Publikováno v:
Journal of Biological Chemistry. 277:49545-49553
Sphingosine kinase catalyzes the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses including mitogenesis, anti-apoptosis, and expression of inflammatory molecules.
Several members of the CLC family of proteins are voltage-gated, and this entire family is sometimes termed the voltage-gated family of Cl- channels (chloride channels). Bioinformatics screening of CLC channels suggests the existence of regions in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afabee643ac8da59250637e4ab10731a
https://doi.org/10.1128/9781555816452.ch11
https://doi.org/10.1128/9781555816452.ch11
Autor:
Richard J D'Andrea, M.A. Vadas, K.L. Jones, C. Butcher, Christopher J. Bagley, Simon C. Barry
Publikováno v:
Cytokine. 14:303-315
A mutant form of the common beta-subunit of the GM-CSF, interleukin-3 (IL3) and IL5 receptors is activated by a 37 residue duplicated segment which includes the WSXWS motif and an adjacent, highly conserved, aliphatic/basic element. Haemopoietic expr
Autor:
Christopher J. Bagley, Angel F. Lopez, Barbara J. McClure, Joanna M. Woodcock, Hayley S. Ramshaw, T.R. Hercus
Publikováno v:
Immunology & Cell Biology. 79:154-159
Asthma is a common and complex inflammatory disease of the airways that remains incurable. Current forms of therapy are long term and may exhibit associated side-effect problems. Major participants in the development of an asthma phenotype include th