Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christopher J Traynham"'
Autor:
Christopher J Traynham, Steve R Roof, Honglan Wang, Robert A Prosak, Lifei Tang, Serge Viatchenko-Karpinski, Hsiang-Ting Ho, Ira O Racoma, Dominic J Catalano, Xin Huang, Yongbin Han, Shang-U Kim, Sandor Gyorke, George E Billman, Frederick A Villamena, Mark T Ziolo
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52005 (2012)
Nitric oxide (NO) and superoxide (O(2) (-)) are important cardiac signaling molecules that regulate myocyte contraction. For appropriate regulation, NO and O(2) (.-) must exist at defined levels. Unfortunately, the NO and O(2) (.-) levels are altered
Externí odkaz:
https://doaj.org/article/8e0cb70510354f61a6e1f4f77eeaac16
Autor:
Rajika Roy, Ancai Yuan, Christopher J. Traynham, Erhe Gao, Konstantinos Drosatos, Gavin Landesberg, Steven J. Forrester, Claudio de Lucia, Douglas G. Tilley, Walter J. Koch, Jessica Pfleger, Jennifer Petovic, Michela Piedepalumbo, Matthew Hoffman, Rosario Scalia, Laurel A. Grisanti, Melissa Lieu, Satoru Eguchi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of cardiac G protein-coupled r
Autor:
Steven J. Forrester, Christopher J. Traynham, Rosario Scalia, Gavin Landesberg, Satoru Eguchi, Erhe Gao, Walter J. Koch, Melissa Lieu, Jennifer Petovic
Publikováno v:
Circulation Research. 125
Nitric oxide (NO) and S-nitrosothiol (SNO) have cardiovascular-protective properties and we have shown that one mechanism is through SNO-modification of G protein-coupled receptor (GPCR) kinase 2 (GRK2). S-nitrosylation at Cys340 (C340S) of GRK2 inhi
Autor:
Meryl C. Woodall, J. Kurt Chuprun, Erhe Gao, Konstantinos Drosatos, Brett R. Brown, Priscila Y. Sato, Jessica Ibetti, Anna Maria Lucchese, Ancai Yuan, Rajika Roy, Walter J. Koch, Doug G. Tilley, Laurel A. Grisanti, Christopher J. Traynham
Publikováno v:
Science signaling. 11(560)
Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the pathogenesis of heart failure after ischemia-reperfusion (IR) inj
Publikováno v:
Pharmacological Research. 110:52-64
Heart failure (HF) is a global epidemic with the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) are prominent regulators of cardiovascular function. Activated GPCRs are “turned off”
Autor:
Andrés Pun García, Christopher J. Traynham, Walter J. Koch, Borja Ibanez, Daohai Yu, Laurel A. Grisanti, Rhonda L. Carter, Ashley A. Repas, Douglas G. Tilley, Anna M. Gumpert, Joshua Gorsky, John W. Calvert, Joseph E. Rabinowitz, Erhe Gao
Publikováno v:
Circulation. 134:153-167
Background: Immune cell–mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous system is known to regulate immune system function through β-adrenergic receptors (βARs
Publikováno v:
Journal of Molecular and Cellular Cardiology. 92:196-202
As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a
Autor:
Jessica Ibetti, Walter J. Koch, Yan Zhou, Jessica I. Gold, Benjamin P. Woodall, Christopher J. Traynham, Alessandro Cannavo, Alexandre G. Vouga, Erhe Gao, Jonathan Hullmann, J. Kurt Chuprun
Publikováno v:
Circulation Research. 117:1001-1012
Rationale : G protein–coupled receptor kinases (GRKs) are dynamic regulators of cellular signaling. GRK5 is highly expressed within myocardium and is upregulated in heart failure. Although GRK5 is a critical regulator of cardiac G protein–coupled
Autor:
Christopher J. Traynham, Erhe Gao, Douglas G. Tilley, Walter J. Koch, Ashley A. Repas, Laurel A. Grisanti
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(52)
Following cardiac injury, early immune cell responses are essential for initiating cardiac remodeling and tissue repair. We previously demonstrated the importance of β2-adrenergic receptors (β2ARs) in the regulation of immune cell localization foll
Autor:
J. Kurt Chuprun, Meryl C. Woodall, Ancai Yuan, Anna Maria Lucchese, Erhe Gao, Priscila Y. Sato, Christopher J. Traynham, Jessica Ibetti, Laurel A. Grisanti, Doug G. Tilley, Walter J. Koch
Publikováno v:
Journal of Molecular and Cellular Cardiology. 112:152-153