Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christopher J Traynham"'
Autor:
Christopher J Traynham, Steve R Roof, Honglan Wang, Robert A Prosak, Lifei Tang, Serge Viatchenko-Karpinski, Hsiang-Ting Ho, Ira O Racoma, Dominic J Catalano, Xin Huang, Yongbin Han, Shang-U Kim, Sandor Gyorke, George E Billman, Frederick A Villamena, Mark T Ziolo
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52005 (2012)
Nitric oxide (NO) and superoxide (O(2) (-)) are important cardiac signaling molecules that regulate myocyte contraction. For appropriate regulation, NO and O(2) (.-) must exist at defined levels. Unfortunately, the NO and O(2) (.-) levels are altered
Externí odkaz:
https://doaj.org/article/8e0cb70510354f61a6e1f4f77eeaac16
Autor:
Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J. Elliott, Christopher J. Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J. Koch
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integr
Externí odkaz:
https://doaj.org/article/70ab970e75e145a7b7e6fbb932036a1c
Autor:
Rajika Roy, Ancai Yuan, Christopher J. Traynham, Erhe Gao, Konstantinos Drosatos, Gavin Landesberg, Steven J. Forrester, Claudio de Lucia, Douglas G. Tilley, Walter J. Koch, Jessica Pfleger, Jennifer Petovic, Michela Piedepalumbo, Matthew Hoffman, Rosario Scalia, Laurel A. Grisanti, Melissa Lieu, Satoru Eguchi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of cardiac G protein-coupled r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9943b5d2886fbe4556ca902d4895978e
https://pubmed.ncbi.nlm.nih.gov/32216616
https://pubmed.ncbi.nlm.nih.gov/32216616
Autor:
Steven J. Forrester, Christopher J. Traynham, Rosario Scalia, Gavin Landesberg, Satoru Eguchi, Erhe Gao, Walter J. Koch, Melissa Lieu, Jennifer Petovic
Publikováno v:
Circulation Research. 125
Nitric oxide (NO) and S-nitrosothiol (SNO) have cardiovascular-protective properties and we have shown that one mechanism is through SNO-modification of G protein-coupled receptor (GPCR) kinase 2 (GRK2). S-nitrosylation at Cys340 (C340S) of GRK2 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44490f64afdb332dbc2f08358e22504
https://doi.org/10.1161/res.125.suppl_1.841
https://doi.org/10.1161/res.125.suppl_1.841
Autor:
Meryl C. Woodall, J. Kurt Chuprun, Erhe Gao, Konstantinos Drosatos, Brett R. Brown, Priscila Y. Sato, Jessica Ibetti, Anna Maria Lucchese, Ancai Yuan, Rajika Roy, Walter J. Koch, Doug G. Tilley, Laurel A. Grisanti, Christopher J. Traynham
Publikováno v:
Science signaling. 11(560)
Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the pathogenesis of heart failure after ischemia-reperfusion (IR) inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca0150a93f061874c927baf2eb1bb36
https://pubmed.ncbi.nlm.nih.gov/30538174
https://pubmed.ncbi.nlm.nih.gov/30538174
Publikováno v:
Pharmacological Research. 110:52-64
Heart failure (HF) is a global epidemic with the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) are prominent regulators of cardiovascular function. Activated GPCRs are “turned off”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9740afbe33659d65420ed09241aee2f
https://doi.org/10.1016/j.phrs.2016.05.008
https://doi.org/10.1016/j.phrs.2016.05.008
Autor:
Andrés Pun García, Christopher J. Traynham, Walter J. Koch, Borja Ibanez, Daohai Yu, Laurel A. Grisanti, Rhonda L. Carter, Ashley A. Repas, Douglas G. Tilley, Anna M. Gumpert, Joshua Gorsky, John W. Calvert, Joseph E. Rabinowitz, Erhe Gao
Publikováno v:
Circulation. 134:153-167
Background: Immune cell–mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous system is known to regulate immune system function through β-adrenergic receptors (βARs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca559461bc37aa507fffd6192d1bfd06
https://doi.org/10.1161/circulationaha.116.022304
https://doi.org/10.1161/circulationaha.116.022304
Publikováno v:
Journal of Molecular and Cellular Cardiology. 92:196-202
As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5625c4b564e3c1d33b3f16b14b8f0a
https://doi.org/10.1016/j.yjmcc.2016.01.027
https://doi.org/10.1016/j.yjmcc.2016.01.027
Autor:
Jessica Ibetti, Walter J. Koch, Yan Zhou, Jessica I. Gold, Benjamin P. Woodall, Christopher J. Traynham, Alessandro Cannavo, Alexandre G. Vouga, Erhe Gao, Jonathan Hullmann, J. Kurt Chuprun
Publikováno v:
Circulation Research. 117:1001-1012
Rationale : G protein–coupled receptor kinases (GRKs) are dynamic regulators of cellular signaling. GRK5 is highly expressed within myocardium and is upregulated in heart failure. Although GRK5 is a critical regulator of cardiac G protein–coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71c2aaba7af5c6cc3f9c58ac5b40293
https://doi.org/10.1161/circresaha.115.306961
https://doi.org/10.1161/circresaha.115.306961
Autor:
Erhe Gao, J K Chuprun, Walter J. Koch, Ancai Yuan, Anna Maria Lucchese, Priscila Y. Sato, Christopher J. Traynham
Publikováno v:
Circulation Research. 119
β-adrenergic receptors (βARs) are critical regulators of cardiac contractility whose function are drastically impaired during heart failure (HF). Activated βARs are regulated via phosphorylation by G-protein coupled receptor kinase-2 (GRK2) and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32fa1e21a2c1b9105411aa3f32038f2b
https://doi.org/10.1161/res.119.suppl_1.449
https://doi.org/10.1161/res.119.suppl_1.449