Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christopher J Tape"'
Autor:
Jinhai Deng, Teng Pan, Dan Wang, Yourae Hong, Zaoqu Liu, Xingang Zhou, Zhengwen An, Lifeng Li, Giovanna Alfano, Gang Li, Luigi Dolcetti, Rachel Evans, Jose M Vicencio, Petra Vlckova, Yue Chen, James Monypenny, Camila Araujo De Carvalho Gomes, Gregory Weitsman, Kenrick Ng, Caitlin McCarthy, Xiaoping Yang, Zedong Hu, Joanna C Porter, Christopher J Tape, Mingzhu Yin, Fengxiang Wei, Manuel Rodriguez-Justo, Jin Zhang, Sabine Tejpar, Richard Beatson, Tony Ng
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2080-2108 (2024)
Abstract Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognized to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify oxal
Externí odkaz:
https://doaj.org/article/5559931ff7c94961b54686129b587544
Autor:
Rachael Natrajan, Heba Sailem, Faraz K Mardakheh, Mar Arias Garcia, Christopher J Tape, Mitch Dowsett, Chris Bakal, Yinyin Yuan
Publikováno v:
PLoS Medicine, Vol 13, Iss 2, p e1001961 (2016)
BackgroundThe intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that is key to cancer progression and evolution. We aimed to assess the degree of micro
Externí odkaz:
https://doaj.org/article/35ff3f6e44eb4dfeadeb84a0e001c74e
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40597 (2012)
ADAM 17 (TNF-α converting enzyme, TACE) is a potential target for cancer therapy, but the small molecule inhibitors reported to date are not specific to this ADAM family member. This membrane-bound metalloproteinase is responsible for ectodomain she
Externí odkaz:
https://doaj.org/article/760cb5010af7480e95abc83b4efb7152
Autor:
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2810-2822.e5 (2019)
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs under
Externí odkaz:
https://doaj.org/article/4fe1b76aeb144cf7aa575df20599c264
Autor:
Mark Nitz, Petra Vlckova, Jahangir Sufi, Christopher J. Tape, Xiao Qin, Yong Jia Bu, Ferran Cardoso Rodriguez, María Ramos Zapatero
Publikováno v:
Nature Protocols. 16:4897-4918
Organoids are biomimetic tissue models comprising multiple cell types and cell states. Post-translational modification (PTM) signaling networks control cellular phenotypes and are frequently dysregulated in diseases such as cancer. Although signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a92bd2c0071785f025877718c7a5a2
https://doi.org/10.1038/s41596-021-00603-4
https://doi.org/10.1038/s41596-021-00603-4
Autor:
Ilaria M. Michelozzi, Eduardo Gomez-Castaneda, Ruben V. C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
Publikováno v:
Blood advances.
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and antitumor efficacy compared with the high-affinity (FMC63-based) CAR used in tisagenlecleucel, in precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed2f0f05acff2656fbf94aef8ae3ab2
https://pubmed.ncbi.nlm.nih.gov/36453632
https://pubmed.ncbi.nlm.nih.gov/36453632
Autor:
Christopher J. Tape, Xiao Qin
Publikováno v:
Trends in Biotechnology. 39:774-787
Organoids are self-organising stem cell-derived ex vivo cultures widely adopted as biomimetic models of healthy and diseased tissues. Traditional low-dimensional experimental methods such as microscopy and bulk molecular analysis have generated remar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b76a9312c8030e430f83a6e9fc2171
https://doi.org/10.1016/j.tibtech.2020.10.013
https://doi.org/10.1016/j.tibtech.2020.10.013
Publikováno v:
Trends in pharmacological sciences. 42(8)
Cardiac physiology and homeostasis are maintained by the interaction of multiple cell types, via both intra- and intercellular signaling pathways. Perturbations in these signaling pathways induced by oncology therapies can reduce cardiac function, ul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6fc4fd1564099131229e2a9ffd2b7b
https://pubmed.ncbi.nlm.nih.gov/34092416
https://pubmed.ncbi.nlm.nih.gov/34092416
Autor:
Ilaria M. Michelozzi, Jahangir Sufi, Thomas A. Adejumo, Persis J. Amrolia, Christopher J. Tape, Alice Giustacchini
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101174-(2022)
Summary: Here, we present a comprehensive protocol for the generation and functional characterization of chimeric antigen receptor (CAR) T cells and their products by mass cytometry in a reproducible and scalable manner. We describe the production of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7010b26b86bfa17347420a858da84d
https://doi.org/10.1016/j.xpro.2022.101174
https://doi.org/10.1016/j.xpro.2022.101174
Autor:
Ilaria M. Michelozzi, Eduardo Gomez Castaneda, Ruben V.C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and anti-tumour efficacy compared to the high-affinity (FMC63 based) CAR used in Tisagenlecleucel, in pre-cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79f0bbfa6bbb39f2b825d5e9d2ba484
https://doi.org/10.1101/2020.09.22.291831
https://doi.org/10.1101/2020.09.22.291831
