Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Christopher J T, Hyland"'
Autor:
Liam M. Joyce, Stephen A. Moggach, Christopher J. T. Hyland, Stephen G. Pyne, Scott G. Stewart
Publikováno v:
The Journal of Organic Chemistry. 88:5391-5402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e81616cac8b333e89ec1f8e9d8a7ee
https://doi.org/10.1021/acs.joc.2c03040
https://doi.org/10.1021/acs.joc.2c03040
Autor:
Quoc Hoang Pham, Andrew J. Tague, Christopher Richardson, Michael G. Gardiner, Stephen G. Pyne, Christopher J. T. Hyland
Publikováno v:
Chemical Science. 14:4893-4900
Formation of valuable spiroheterocycles with multiple contiguous stereogenic centres from palladium-catalysed enantioselective (3 + 2) cycloaddition reactions of sulfamidate-derived azadienes and vinylcyclopropanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0e3a774c0a007d755c9742f9df6640
https://doi.org/10.1039/d3sc01510f
https://doi.org/10.1039/d3sc01510f
Autor:
Quoc Hoang Pham, Andrew J. Tague, Stephen G. Pyne, Christopher Richardson, Christopher J. T. Hyland
Publikováno v:
Chemical Science
The Pd-catalysed asymmetric allylic alkylation (Pd-AAA) of prochiral enamide anions derived from 5H-oxathiazole 2,2-dioxides has been developed. Various 4,5-disubstituted and 4-substituted cyclic sulfamidate imines have participated in the transforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ea382f2e9915e6dd11f7dfef1609f
http://europepmc.org/articles/PMC8494038
http://europepmc.org/articles/PMC8494038
Autor:
Andrew J. Tague, Christopher Richardson, Melanie A. Drew, Stephen G. Pyne, Christopher J. T. Hyland
Publikováno v:
Organic Letters. 23:4635-4639
A two-step Pd-catalyzed (3 + 2) cycloaddition/HNO2 elimination reaction sequence has been developed to give novel cyclic 1,3-dien-5-yne systems from Pd-stabilized zwitterionic 1,3-dipoles and 2-nitro-1,3-enyne substrates. The process is highly atom-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e679739f79a2139a7d85dc68cf3bdef8
https://doi.org/10.1021/acs.orglett.1c01364
https://doi.org/10.1021/acs.orglett.1c01364
Publikováno v:
ACS Catalysis. 11:5795-5807
Density functional theory calculations were used to investigate the mechanisms of established hydroalkylation reactions of styrenes with 1,3-diketones that are promoted by either AuCl3/AgOTf or AgOTf catalyst systems. In the former case, our studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83341de96b6b805929983de045f405a
https://doi.org/10.1021/acscatal.0c05260
https://doi.org/10.1021/acscatal.0c05260
Publikováno v:
Organic & Biomolecular Chemistry. 19:7098-7115
Medium-ring (7-9-membered) benzo-fused N-heterocycles - a core structure in several important pharmaceuticals - have a diverse range of interesting conformational and stereochemical properties which arise from restricted bond rotation in the non-arom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3578d3bbbcf7f0a5ef1c89dd09bd238a
https://doi.org/10.1039/d1ob00836f
https://doi.org/10.1039/d1ob00836f
Publikováno v:
Chemical Reviews. 121:8685-8755
The past decade has witnessed the golden age of homogeneous gold-catalyzed reactions, especially those that involve the transformation of highly strained molecules into complex molecular architectures. Gold catalysts, with unique electronic propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db758d51efa20d03e02768415321bfb
https://doi.org/10.1021/acs.chemrev.0c00624
https://doi.org/10.1021/acs.chemrev.0c00624
Publikováno v:
Synlett. 31:916-924
A diastereoselective palladium-catalyzed dearomative formal (4+2) cycloaddition between vinyl benzoxazinanones and 3-nitroindoles has been developed. This reaction provides a concise route to tetrahydro-5H-indolo[2,3-b]quinolines in excellent yield (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6885bd83165f1462e761e96715643ab1
https://doi.org/10.1055/s-0040-1707995
https://doi.org/10.1055/s-0040-1707995
Autor:
Melanie A. Drew, Stephen G. Pyne, Srinivas Thadkapally, Christopher Richardson, Christopher J. T. Hyland, Alireza Ariafard, Kaveh Farshadfar
Publikováno v:
Chemical Science. 11:10945-10950
Efficient methods for the synthesis of fused-aromatic rings is a critical endeavour in the creation of new pharmaceuticals and materials. A direct method for preparing these systems is the tetradehydro-Diels–Alder reaction, however this is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f62e38762bed2bed224076afe1d9853
https://doi.org/10.1039/d0sc04390g
https://doi.org/10.1039/d0sc04390g
Autor:
Ronald W. Brown, Vicky M. Avery, Melissa Sykes, Paul A. Keller, Ashraf M. Abdel-Megeed, Amy J. Jones, Christopher J. T. Hyland, Jonathan B. Baell, Marcel Kaiser
Publikováno v:
RSC Med Chem
African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa. High-throughput screening identified the thiazolyl–benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72a8f11e2e7a5222d6d5ed9e132a513
https://doi.org/10.1039/d0md00277a
https://doi.org/10.1039/d0md00277a