Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christopher J Stubenrauch"'
Autor:
Edward M Germany, Nakajohn Thewasano, Kenichiro Imai, Yuki Maruno, Rebecca S Bamert, Christopher J Stubenrauch, Rhys A Dunstan, Yue Ding, Yukari Nakajima, XiangFeng Lai, Chaille T Webb, Kentaro Hidaka, Kher Shing Tan, Hsinhui Shen, Trevor Lithgow, Takuya Shiota
Publikováno v:
eLife, Vol 12 (2024)
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a ‘β-signal’ imprinted in the final β-strand of the OMP engages th
Externí odkaz:
https://doaj.org/article/626715ed22904b7dba0546e776b3b008
Autor:
Natalia C Rosas, Jonathan Wilksch, Jake Barber, Jiahui Li, Yanan Wang, Zhewei Sun, Andrea Rocker, Chaille T Webb, Laura Perlaza-Jiménez, Christopher J Stubenrauch, Vijaykrishna Dhanasekaran, Jiangning Song, George Taiaroa, Mark Davies, Richard A Strugnell, Qiyu Bao, Tieli Zhou, Michael J McDonald, Trevor Lithgow
Publikováno v:
eLife, Vol 12 (2023)
Antibiotic resistance is driven by selection, but the degree to which a bacterial strain’s evolutionary history shapes the mechanism and strength of resistance remains an open question. Here, we reconstruct the genetic and evolutionary mechanisms o
Externí odkaz:
https://doaj.org/article/06b253a4bac44817adcc36b210c3c5fe
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001523 (2022)
Bacteria have membrane-spanning efflux pumps to secrete toxic compounds ranging from heavy metal ions to organic chemicals, including antibiotic drugs. The overall architecture of these efflux pumps is highly conserved: with an inner membrane energy-
Externí odkaz:
https://doaj.org/article/596736953c754b72a3f67718f23bc545
Autor:
Eric Mandela, Christopher J Stubenrauch, David Ryoo, Hyea Hwang, Eli J Cohen, Von L Torres, Pankaj Deo, Chaille T Webb, Cheng Huang, Ralf B Schittenhelm, Morgan Beeby, JC Gumbart, Trevor Lithgow, Iain D Hay
Publikováno v:
eLife, Vol 11 (2022)
The cell envelope of Gram-negative bacteria consists of two membranes surrounding a periplasm and peptidoglycan layer. Molecular machines spanning the cell envelope depend on spatial constraints and load-bearing forces across the cell envelope and su
Externí odkaz:
https://doaj.org/article/6a16e12097bc4b968927c1ab356f57a7
Autor:
Sachith D. Gunasinghe, Takuya Shiota, Christopher J. Stubenrauch, Keith E. Schulze, Chaille T. Webb, Alex J. Fulcher, Rhys A. Dunstan, Iain D. Hay, Thomas Naderer, Donna R. Whelan, Toby D.M. Bell, Kirstin D. Elgass, Richard A. Strugnell, Trevor Lithgow
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2782-2794 (2018)
The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is unclear. We developed a direct stochastic optical reconstruction microscopy (dSTORM) metho
Externí odkaz:
https://doaj.org/article/4887ae9993cc45509e28c04949566915
Publikováno v:
Nature Reviews Microbiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22cc03280c0814ed87601aedde689ba3
https://doi.org/10.1038/s41579-023-00862-w
https://doi.org/10.1038/s41579-023-00862-w
Autor:
Christopher J. Stubenrauch, Jiahui Li, Jiawei Wang, Jianzhong Su, Qi Li, Jiasheng Cai, Wei Dai
Publikováno v:
Nucleic Acids Research
From industry to food to health, bacteria play an important role in all facets of life. Some of the most important bacteria have been purposely engineered to produce commercial quantities of antibiotics and therapeutics, and non-classical secretion s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77088094356fa9ccb4a536b2d0a955bd
https://doi.org/10.1093/nar/gkab814
https://doi.org/10.1093/nar/gkab814
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They are multimeric extrusions, which are moved out of the bacterial cell through an integral outer membrane protein called usher. The complex fold
Externí odkaz:
https://doaj.org/article/096421f49a6c4b189745c15ddf65299d
Autor:
Laura Perlaza-Jiménez, Kher-Shing Tan, Sarah J. Piper, Rachel M. Johnson, Rebecca S. Bamert, Christopher J. Stubenrauch, Alexander Wright, David Lupton, Trevor Lithgow, Matthew J. Belousoff
Publikováno v:
Microbiology Spectrum. 10
Antibiotic resistance poses a critical problem to human health and decreases the utility of these lifesaving drugs. Of particular concern is the “superbug” methicillin-resistant Staphylococcus aureus (MRSA), for which treatment of infection requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e21ba00419d30a2f3ba5f1d55fd4829
https://doi.org/10.1128/spectrum.00583-22
https://doi.org/10.1128/spectrum.00583-22
Autor:
Laura, Perlaza-Jiménez, Kher-Shing, Tan, Sarah J, Piper, Rachel M, Johnson, Rebecca S, Bamert, Christopher J, Stubenrauch, Alexander, Wright, David, Lupton, Trevor, Lithgow, Matthew J, Belousoff
Publikováno v:
Microbiology spectrum. 10(4)
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen that presents great health concerns. Treatment requires the use of last-line antibiotics, such as members of the oxazolidinone family, of which linezolid is the first member t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd06f314c8bd0646e3357372048d661
https://pubmed.ncbi.nlm.nih.gov/35736238
https://pubmed.ncbi.nlm.nih.gov/35736238