Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christopher J Smyrniotis"'
Autor:
Eric K Hoobler, Ganesha Rai, Andrew G S Warrilow, Steven C Perry, Christopher J Smyrniotis, Ajit Jadhav, Anton Simeonov, Josie E Parker, Diane E Kelly, David J Maloney, S L Kelly, Theodore R Holman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65928 (2013)
We report the discovery of a novel dual inhibitor targeting fungal sterol 14α-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. A s
Externí odkaz:
https://doaj.org/article/7993a077535548118bd36c4560fa1ddb
Autor:
Christopher J. Smyrniotis, Diane E. Kelly, Theodore R. Holman, Andrew G. S. Warrilow, David D. Hughes, Claire L. Price, Josie E. Parker, Nicola J. Rolley, Vera Thoss, Steven L. Kelly, W. David Nes
Publikováno v:
Scientific Reports
Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14α-demethylase (the target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole drug target), respectively. Lanosterol, eburicol and obtusifoliol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893eb523ad7ede097eb7c167ad43c913
https://cronfa.swan.ac.uk/Record/cronfa34335
https://cronfa.swan.ac.uk/Record/cronfa34335
Autor:
David J. Maloney, Jennifer Yeung, Theodore R. Holman, Jin Ren, Benjamin E. Tourdot, Diane K. Luci, Ajit Jadhav, Joanne Vesci, Anton Simeonov, Steven E. McKenzie, Michael Holinstat, Pilar Fernandez-Perez, Christopher J. Smyrniotis
Publikováno v:
Blood. 124(14)
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet activity often results in thrombotic complications leading to myocardial infarction and stroke. Activation of the FcγRIIa re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf8bbadd51e88966fe897f8ffa69831
https://pubmed.ncbi.nlm.nih.gov/25278566
https://pubmed.ncbi.nlm.nih.gov/25278566
Publikováno v:
Biochemistry
5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd490b3688c2616606a237a08bce6f
https://pubmed.ncbi.nlm.nih.gov/24893149
https://pubmed.ncbi.nlm.nih.gov/24893149
Autor:
Diane E. Kelly, Andrew G. S. Warrilow, Ganesha Rai, Eric K. Hoobler, Steven L. Kelly, Theodore R. Holman, Ajit Jadhav, David J. Maloney, Josie E. Parker, Anton Simeonov, Christopher J. Smyrniotis, Steve Perry
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65928 (2013)
PLoS ONE, Vol 8, Iss 6, p e65928 (2013)
We report the discovery of a novel dual inhibitor targeting fungal sterol 14α-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f644e841e113549f48d38bc9b255ac
http://europepmc.org/articles/PMC3691235
http://europepmc.org/articles/PMC3691235