Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Christopher J Sinal"'
Autor:
Jay Toulany, Sebastian D Parlee, Christopher J Sinal, Kathryn Slayter, Shelly McNeil, Kerry B Goralski
Publikováno v:
Endocrine Connections, Vol 5, Iss 6, Pp 70-81 (2016)
Prochemerin is the inactive precursor of the adipokine chemerin. Proteolytic processing is obligatory for the conversion of prochemerin into active chemerin and subsequent regulation of cellular processes via the chemokine-like receptor 1 (CMKLR1). E
Externí odkaz:
https://doaj.org/article/96a245eb356e4eddb738cc45e6e52857
Autor:
Sebastian D Parlee, Jenna O McNeil, Shanmugam Muruganandan, Christopher J Sinal, Kerry B Goralski
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51072 (2012)
Chemerin is a leukocyte chemoattractant and adipokine with important immune and metabolic roles. Chemerin, secreted in an inactive form prochemerin, undergoes C-terminal proteolytic cleavage to generate active chemerin, a ligand for the chemokine-lik
Externí odkaz:
https://doaj.org/article/932b16fbdaa14e608cd83afcdc31a578
Autor:
Rebekka Pohl, Susanne Feder, Elisabeth M. Haberl, Lisa Rein-Fischboeck, Thomas S. Weiss, Marlen Spirk, Astrid Bruckmann, Nichole McMullen, Christopher J. Sinal, Christa Buechler
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 132 (2022)
Non-alcoholic steatohepatitis (NASH) is marked by macrophage infiltration and inflammation. Chemerin is a chemoattractant protein and is abundant in hepatocytes. The aim of this study was to gain insight into the role of hepatocyte-produced prochemer
Externí odkaz:
https://doaj.org/article/539de5e026b348d78767ce25dfe19292
Publikováno v:
Frontiers in Endocrinology. 13
When compared to adipocytes in other anatomical sites, the interaction of bone marrow resident adipocytes with the other cells in their microenvironment is less well understood. Bone marrow adipocytes originate from a resident, self-renewing populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fed1701e244b5e586727bb0d481258
https://doi.org/10.3389/fendo.2022.903925
https://doi.org/10.3389/fendo.2022.903925
Autor:
Rebekka Pohl, Laura Eichelberger, Susanne Feder, Elisabeth M. Haberl, Lisa Rein-Fischboeck, Nichole McMullen, Christopher J. Sinal, Astrid Bruckmann, Thomas S. Weiss, Michael Beck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Reiner Wiest, Josef Wanninger, Christa Buechler
Publikováno v:
Pohl, Rebekka; Eichelberger, Laura; Feder, Susanne; Haberl, Elisabeth M; Rein-Fischboeck, Lisa; McMullen, Nichole; Sinal, Christopher J; Bruckmann, Astrid; Weiss, Thomas S; Beck, Michael; Höring, Marcus; Krautbauer, Sabrina; Liebisch, Gerhard; Wiest, Reiner; Wanninger, Josef; Buechler, Christa (2022). Hepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis. Molecular and cellular biochemistry, 477(8), pp. 2059-2071. Springer 10.1007/s11010-022-04430-3
Non-alcoholic steatohepatitis (NASH) is a rapidly growing liver disease. The chemoattractant chemerin is abundant in hepatocytes, and hepatocyte expressed prochemerin protected from NASH. Prochemerin is inactive and different active isoforms have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d2fdad06a6e1e6ba0426490eb9dc5c
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 11, Pp 2503-2514 (2006)
Apolipoprotein A-IV (apoA-IV) is a 46 kDa glycoprotein that associates with triglyceride-rich and high density lipoproteins. Blood levels of apoA-IV generally correlate with triglyceride levels and are increased in diabetic patients. This study inves
Externí odkaz:
https://doaj.org/article/e5d84ab2fda94455af1c795d3aef0f21
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2595-2604 (2005)
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid homeostasis. This study was undertaken to investigate the pathological consequences of the loss of FX
Externí odkaz:
https://doaj.org/article/a8f92fbbe5b84b11ae6e7991d50547e2
Autor:
Amina M. Bagher, Ganesh A. Thakur, Robert B. Laprairie, Melanie E. M. Kelly, Eileen M. Denovan-Wright, Christopher J. Sinal, Elizabeth A. Cairns, Pushkar M. Kulkarni, Adel Zrein, Jillian L. Rourke
Publikováno v:
Neuropharmacology
Huntington’s disease (HD) is an inherited progressive neurodegenerative disease characterized by motor, cognitive, and behavioural changes. One of the earliest changes to occur in HD is a reduction in cannabinoid 1 receptor (CB(1)) levels in the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd016b59610315da927267995660e8c
https://doi.org/10.1016/j.neuropharm.2019.03.033
https://doi.org/10.1016/j.neuropharm.2019.03.033
Publikováno v:
International Journal of Molecular Sciences; Volume 21; Issue 19; Pages: 7205
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7205, p 7205 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7205, p 7205 (2020)
Murine chemerin is C-terminally processed to the bioactive isoforms, muChem-156 and muChem-155, among which the longer variant protects from hepatocellular carcinoma (HCC). However, the role of muChem-155 is mostly unknown. Here, we aimed to compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a872ffab8dc7242c43576252a70f1a
Autor:
Mahtab Tavasoli, Sarah Lahire, Stanislav Sokolenko, Robyn Novorolsky, Sarah Anne Reid, Abir Lefsay, Meredith O. C. Otley, Kitipong Uaesoontrachoon, Joyce Rowsell, Sadish Srinivassane, Molly Praest, Alexandra MacKinnon, Melissa Stella Mammoliti, Ashley Alyssa Maloney, Marina Moraca, J. Pedro Fernandez-Murray, Meagan McKenna, Christopher J. Sinal, Kanneboyina Nagaraju, George S. Robertson, Eric P. Hoffman, Christopher R. McMaster
Publikováno v:
Nature communications. 13(1)
CHKB encodes one of two mammalian choline kinase enzymes that catalyze the first step in the synthesis of the membrane phospholipid phosphatidylcholine. In humans and mice, inactivation of the CHKB gene (Chkb in mice) causes a recessive rostral-to-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c03787b601c23aaa02007697fbedd85
https://pubmed.ncbi.nlm.nih.gov/35322809
https://pubmed.ncbi.nlm.nih.gov/35322809