Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Christopher J R Loewen"'
Autor:
Garrett Strawn, Ryan W K Wong, Barry P Young, Michael Davey, Corey Nislow, Elizabeth Conibear, Christopher J R Loewen, Thibault Mayor
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract The yeast Saccharomyces cerevisiae is widely used as a host cell for recombinant protein production due to its fast growth, cost-effective culturing, and ability to secrete large and complex proteins. However, one major drawback is the relat
Externí odkaz:
https://doaj.org/article/16bae354f68542b19615ff87f578b08a
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Genetic testing is widely used in evaluating a patient’s predisposition to hereditary diseases. In the case of cancer, when a functionally impactful mutation (i.e. genetic variant) is identified in a disease-relevant gene, the p
Externí odkaz:
https://doaj.org/article/1f0dd71d3bcf464b98546c41f890974d
Autor:
Kathryn L. Post, Manuel Belmadani, Payel Ganguly, Fabian Meili, Riki Dingwall, Troy A. McDiarmid, Warren M. Meyers, Caitlin Herrington, Barry P. Young, Daniel B. Callaghan, Sanja Rogic, Matthew Edwards, Ana Niciforovic, Alessandro Cau, Catharine H. Rankin, Timothy P. O’Connor, Shernaz X. Bamji, Christopher J. R. Loewen, Douglas W. Allan, Paul Pavlidis, Kurt Haas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mutations in PTEN have been associated with various human disease, including autism spectrum disorder (ASD) and cancer. Here, the authors assess the function of 106 PTEN variants in yeast, invertebrate models and cell culture and report that PTEN var
Externí odkaz:
https://doaj.org/article/1edea52849604fc89ff112a464d20e83
Autor:
Payel Ganguly, Landiso Madonsela, Jesse T Chao, Christopher J R Loewen, Timothy P O'Connor, Esther M Verheyen, Douglas W Allan
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009774 (2021)
Gene variant discovery is becoming routine, but it remains difficult to usefully interpret the functional consequence or disease relevance of most variants. To fill this interpretation gap, experimental assays of variant function are becoming common
Externí odkaz:
https://doaj.org/article/5cb487758be84e0eb6cf26744bfaff89
Autor:
Nicholas A. T. Irwin, Benjamin J. E. Martin, Barry P. Young, Martin J. G. Browne, Andrew Flaus, Christopher J. R. Loewen, Patrick J. Keeling, LeAnn J. Howe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Dinoflagellates are known to use dinoflagellate-viral-nucleoproteins (DVNPs) in place of histones, yet this evolutionary transition is not well understood. Here, Irwin et al. use yeast expressing DVNP to show that DVNP displaces histones and that his
Externí odkaz:
https://doaj.org/article/52638ea85b694df989579b49775e0ee6
Autor:
Claire Bomkamp, Nirmala Padmanabhan, Benyamin Karimi, Yuan Ge, Jesse T. Chao, Christopher J. R. Loewen, Tabrez J. Siddiqui, Ann Marie Craig
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2019)
Formation of synapses between neurons depends in part on binding between axonal and dendritic cell surface synaptic organizing proteins, which recruit components of the developing presynaptic and postsynaptic specializations. One of these presynaptic
Externí odkaz:
https://doaj.org/article/a21c259f7a744c2e80735e08d29aee32
Autor:
John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1039-1049 (2016)
A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stre
Externí odkaz:
https://doaj.org/article/e4ad6a9d9de942b1a8efd2584d4da9bd
Autor:
Warren M. Meyers, Rocio Hollman, Christopher J. R. Loewen, Pamela Dean, Kenneth A. Matreyek, Jesse T. Chao, Douglas M. Fowler, Kurt Haas, Calvin D. Roskelley, Fabian Meili
Publikováno v:
Cancer Research. 80:2775-2789
As sequencing becomes more economical, we are identifying sequence variations in the population faster than ever. For disease-associated genes, it is imperative that we differentiate a sequence variant as either benign or pathogenic, such that the ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9821f436220d85c28bb26ac11dd620f9
https://doi.org/10.1158/0008-5472.can-19-3278
https://doi.org/10.1158/0008-5472.can-19-3278
Autor:
Esther M. Verheyen, Jesse T. Chao, Landiso Madonsela, Timothy P. O'Connor, Christopher J. R. Loewen, Douglas W. Allan, Payel Ganguly
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009774 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009774 (2021)
Gene variant discovery is becoming routine, but it remains difficult to usefully interpret the functional consequence or disease relevance of most variants. To fill this interpretation gap, experimental assays of variant function are becoming common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9a476d2d2368043f86f71177c014dc
http://europepmc.org/articles/PMC8448351
http://europepmc.org/articles/PMC8448351
Publikováno v:
Journal of Cell Biology. 220
ER-plasma membrane (PM) contacts are proposed to be held together by distinct families of tethering proteins, which in yeast include the VAP homologues Scs2/22, the extended-synaptotagmin homologues Tcb1/2/3, and the TMEM16 homologue Ist2. It is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abd7ec5d8ddca7d1d0918201b017464
https://doi.org/10.1083/jcb.201910161
https://doi.org/10.1083/jcb.201910161