Flower lose, a cell fitness marker, predicts COVID‐19 prognosis

Autor: Michail Yekelchyk, Esha Madan, Jochen Wilhelm, Kirsty R Short, António M Palma, Linbu Liao, Denise Camacho, Everlyne Nkadori, Michael T Winters, Emily S Rice, Inês Rolim, Raquel Cruz‐Duarte, Christopher J Pelham, Masaki Nagane, Kartik Gupta, Sahil Chaudhary, Thomas Braun, Raghavendra Pillappa, Mark S Parker, Thomas Menter, Matthias Matter, Jasmin Dionne Haslbauer, Markus Tolnay, Kornelia D Galior, Kristina A Matkwoskyj, Stephanie M McGregor, Laura K Muller, Emad A Rakha, Antonio Lopez‐Beltran, Ronny Drapkin, Maximilian Ackermann, Paul B Fisher, Steven R Grossman, Andrew K Godwin, Arutha Kulasinghe, Ivan Martinez, Clay B Marsh, Benjamin Tang, Max S Wicha, Kyoung Jae Won, Alexandar Tzankov, Eduardo Moreno, Rajan Gogna

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-17 (2021)

Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool.

Externí odkaz: https://doaj.org/article/f8eb078fb27a469bb4350f69d131fd6a

Contributors

Autor: Paban K. Agrawala, Christopher Alvarado, Mohammed Amir, Ksenija Bernau, Aditi Bhattacharya, Biswajit Biswas, Megan Block, Anvitha Boosani, Chandra S. Boosani, Allan R. Brasier, Julia A. Brown, Rajasree Chakraborty, Abhijit Das, Nikhitha Dasari, Johanna K. DiStefano, B.S. Dwarakanath, Tohru Fukai, Anil Bhanudas Gaikwad, Fangyan Gong, Rosalba Gornati, Ritobrata Goswami, Palanikumar Gunasekar, Noopur Gupta, Ebrahim Bani Hassan, Gopal P. Jadhav, Natasha Victoria Jain, Fang Jiang, Wanlin Jiang, Jonathan Kreger, Yogesh A. Kulkarni, Patricia N. Le, Lei Liu, Jayant Maini, Papiya Mondal, Kenta Nakai, Umamaheswari Natarajan, Michael T. Olson, Christina Pagiatakis, Madhura R. Pandkar, Amit M. Pant, Roberto Papait, Srinivas Patnaik, Christopher J. Pelham, Anu Prakash, Appu Rathinavelu, Nathan Sandbo, Subhajit Sarkar, Ajay Sharma, Nisha Sharma, Vineeta Sharma, Niharika Shiva, Sanjeev Shukla, Lakshman Singh, Sukhveer Singh, Saurabh Singhal, Vikas Srivastava, Varadarajan Sudhahar, Céline Tiffon, Masuko Ushio-Fukai, Alexis Vandenbon, Judy Weng, Jesse Woo, Xiumei Wu, Pooja Yadav, Melody Y. Zeng

Publikováno v: Epigenetics in Organ Specific Disorders ISBN: 9780128239315

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b7c6b2d58d0b9af9a066b8a109a3f57
https://doi.org/10.1016/b978-0-12-823931-5.09990-4

Flower lose, a cell fitness marker, predicts COVID‐19 prognosis

Autor: Christopher J Pelham, Esha Madan, Markus Tolnay, António M Palma, Emad A. Rakha, Stephanie M. McGregor, Maximilian Ackermann, Everlyne Nkadori, Alexandar Tzankov, Laura K. Muller, Linbu Liao, Mark S. Parker, Emily S Rice, Jasmin D. Haslbauer, Thomas Braun, Raquel Cruz-Duarte, Andrew K. Godwin, Max S. Wicha, Thomas Menter, Matthias S. Matter, Denise Camacho, Benjamin Tang, Kirsty R. Short, Kyoung-Jae Won, Paul B. Fisher, Michail Yekelchyk, Kristina A Matkwoskyj, Eduardo Moreno, Sahil Chaudhary, Rajan Gogna, Kornelia Galior, Inês Rolim, Masaki Nagane, Ronny Drapkin, Michael T. Winters, Kartik Gupta, Antonio Lopez-Beltran, Ivan Martinez, Arutha Kulasinghe, Clay B. Marsh, Jochen Wilhelm, Steven R Grossman, Raghavendra Pillappa

Publikováno v: EMBO Molecular Medicine
Yekelchyk, M, Madan, E, Wilhelm, J, Short, K R, Palma, A M, Liao, L, Camacho, D, Nkadori, E, Winters, M T, Rice, E S, Rolim, I, Cruz-Duarte, R, Pelham, C J, Nagane, M, Gupta, K, Chaudhary, S, Braun, T, Pillappa, R, Parker, M S, Menter, T, Matter, M, Haslbauer, J D, Tolnay, M, Galior, K D, Matkwoskyj, K A, McGregor, S M, Muller, L K, Rakha, E A, Lopez-Beltran, A, Drapkin, R, Ackermann, M, Fisher, P B, Grossman, S R, Godwin, A K, Kulasinghe, A, Martinez, I, Marsh, C B, Tang, B, Wicha, M S, Won, K J, Tzankov, A, Moreno, E & Gogna, R 2021, ' Flower lose, a cell fitness marker, predicts COVID-19 prognosis ', EMBO Molecular Medicine, vol. 13, no. 11, e13714 . https://doi.org/10.15252/emmm.202013714
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)

Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045218b1b4e74ca44637e231ad591f82
https://doi.org/10.15252/emmm.202013714

HIF-transcribed p53 chaperones HIF-1α

Autor: Maria Leonor Peixoto, Rajan Gogna, Esha Madan, Aliya Chandaria, Eduardo Moreno, Carlos Alfredo Lopes de Carvalho, Joaquim Cabral-Teixeira, Antonio Beltran, Uttam Pati, Ana R. Tomás, Periannan Kuppusamy, António M Palma, Vanessa Henriques, Christopher J Pelham, Antonio Galzerano, Taylor M. Parker, Masaki Nagane, Karuppaiyah Selvendiran, Rita Canas-Marques

Publikováno v: Nucleic Acids Research

Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects via activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d768640cd67612b07d2eca7a81fc1c
https://doi.org/10.1093/nar/gkz766

SPARC-p53: The double agents of cancer

Autor: Denise, Camacho, Joana P, Jesus, António M, Palma, Sofia A, Martins, Alexandre, Afonso, Maria Leonor, Peixoto, Christopher J, Pelham, Eduardo, Moreno, Rajan, Gogna

Publikováno v: Advances in cancer research. 148

Cancer is a complex disease with high incidence and mortality rates. The important role played by the tumor microenvironment in regulating oncogenesis, tumor growth, and metastasis is by now well accepted in the scientific community. SPARC is known t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cce7e63e37003e1578c427da936a746e
https://pubmed.ncbi.nlm.nih.gov/32723563