Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Christopher J Papasian"'
Publikováno v:
Orthopedic Research and Reviews, Vol 2011, Iss default, Pp 11-21 (2011)
Chuan Qiu1,2, Christopher J Papasian2, Hong-Wen Deng1,2,3,4, Hui Shen1,21Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana,
Externí odkaz:
https://doaj.org/article/6ac56b021d5c4ad2a5b238d071d19719
Autor:
Li-Jun Tan, Hu Zhu, Hao He, Ke-Hao Wu, Jian Li, Xiang-Ding Chen, Ji-Gang Zhang, Hui Shen, Qing Tian, Marie Krousel-Wood, Christopher J Papasian, Claude Bouchard, Louis Pérusse, Hong-Wen Deng
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96149 (2014)
Obesity is a major public health problem with a significant genetic component. Multiple DNA polymorphisms/genes have been shown to be strongly associated with obesity, typically in populations of European descent. The aim of this study was to verify
Externí odkaz:
https://doaj.org/article/788ae98b2fc74d15823c04e7c81f264e
Autor:
Zhou Zhou, Ruidong Miao, Shengping Huang, Brandon Elder, Tim Quinn, Christopher J Papasian, Jifeng Zhang, Daping Fan, Y Eugene Chen, Mingui Fu
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82542 (2013)
Autoimmune gastritis is an organ-specific autoimmune disease of the stomach associated with pernicious anemia. The previous work from us and other groups identified MCPIP1 as an essential factor controlling inflammation and immune homeostasis. MCPIP1
Externí odkaz:
https://doaj.org/article/62dbf9d58c6243909ec1b98a5f63962e
Autor:
Hui Shen, Jian Li, Jigang Zhang, Chao Xu, Yan Jiang, Zikai Wu, Fuping Zhao, Li Liao, Jun Chen, Yong Lin, Qing Tian, Christopher J Papasian, Hong-Wen Deng
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59494 (2013)
Whole genome sequencing studies are essential to obtain a comprehensive understanding of the vast pattern of human genomic variations. Here we report the results of a high-coverage whole genome sequencing study for 44 unrelated healthy Caucasian adul
Externí odkaz:
https://doaj.org/article/365afc58c8654b5dba660759284a3a85
Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.
Autor:
Lu Sun, Li-Jun Tan, Shu-Feng Lei, Xiang-Ding Chen, Xi Li, Rong Pan, Fang Yin, Quan-Wei Liu, Xiao-Feng Yan, Christopher J Papasian, Hong-Wen Deng
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27325 (2011)
Femoral neck geometric parameters (FNGPs), such as periosteal diameter (W), cross-sectional area (CSA), cortical thickness (CT), buckling ratio (BR), and section modulus (Z), are highly genetically correlated with body lean mass. However, the specifi
Externí odkaz:
https://doaj.org/article/44bdefcae26a4dc28148f35b92bad335
Autor:
Tie-Lin Yang, Yan Guo, Hui Shen, Shu-Feng Lei, Yong-Jun Liu, Jian Li, Yao-Zhong Liu, Na Yu, Jia Chen, Ting Xu, Yu Cheng, Qing Tian, Ping Yu, Christopher J Papasian, Hong-Wen Deng
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21595 (2011)
Mitochondria play a central role in ATP production and energy metabolism. Previous studies suggest that common variants in mtDNA are associated with several common complex diseases, including obesity. To test the hypothesis that common mtDNA variants
Externí odkaz:
https://doaj.org/article/0ab465a9fb734ece874eeababf758b29
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14288 (2010)
When testing association between rare variants and diseases, an efficient analytical approach involves considering a set of variants in a genomic region as the unit of analysis. One factor complicating this approach is that the vast majority of rare
Externí odkaz:
https://doaj.org/article/c7542a3a202c47d492aaa5aec908b9c9
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13857 (2010)
Technology advances have promoted gene-based sequencing studies with the aim of identifying rare mutations responsible for complex diseases. A complication in these types of association studies is that the vast majority of non-synonymous mutations ar
Externí odkaz:
https://doaj.org/article/948d88fc870c480f90b4525ad9e8195c
Autor:
Yan Guo, Li-Jun Tan, Shu-Feng Lei, Tie-Lin Yang, Xiang-Ding Chen, Feng Zhang, Yuan Chen, Feng Pan, Han Yan, Xiaogang Liu, Qing Tian, Zhi-Xin Zhang, Qi Zhou, Chuan Qiu, Shan-Shan Dong, Xiang-Hong Xu, Yan-Fang Guo, Xue-Zhen Zhu, Shan-Lin Liu, Xiang-Li Wang, Xi Li, Yi Luo, Li-Shu Zhang, Meng Li, Jin-Tang Wang, Ting Wen, Betty Drees, James Hamilton, Christopher J Papasian, Robert R Recker, Xiao-Ping Song, Jing Cheng, Hong-Wen Deng
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000806 (2010)
Osteoporosis is a major public health problem. It is mainly characterized by low bone mineral density (BMD) and/or low-trauma osteoporotic fractures (OF), both of which have strong genetic determination. The specific genes influencing these phenotypi
Externí odkaz:
https://doaj.org/article/e625308da1c240e195cf89b00149d2c3
Autor:
Lei Zhang, Aaron J Bonham, Jian Li, Yu-Fang Pei, Jie Chen, Christopher J Papasian, Hong-Wen Deng
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8133 (2009)
The availability of a large number of dense SNPs, high-throughput genotyping and computation methods promotes the application of family-based association tests. While most of the current family-based analyses focus only on individual traits, joint an
Externí odkaz:
https://doaj.org/article/7a31cfef6f03466280016b8c64785fea