Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Christopher J Ormandy"'
Autor:
Catherine L Piggin, Daniel L Roden, Andrew M K Law, Mark P Molloy, Christoph Krisp, Alexander Swarbrick, Matthew J Naylor, Maria Kalyuga, Warren Kaplan, Samantha R Oakes, David Gallego-Ortega, Susan J Clark, Jason S Carroll, Nenad Bartonicek, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008531 (2020)
Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor ELF5 as a potential modulator of estr
Externí odkaz:
https://doaj.org/article/f5de2fac668846768ca5f83785f674e7
Autor:
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92
Autor:
David Gallego-Ortega, Anita Ledger, Daniel L Roden, Andrew M K Law, Astrid Magenau, Zoya Kikhtyak, Christina Cho, Stephanie L Allerdice, Heather J Lee, Fatima Valdes-Mora, David Herrmann, Robert Salomon, Adelaide I J Young, Brian Y Lee, C Marcelo Sergio, Warren Kaplan, Catherine Piggin, James R W Conway, Brian Rabinovich, Ewan K A Millar, Samantha R Oakes, Tatyana Chtanova, Alexander Swarbrick, Matthew J Naylor, Sandra O'Toole, Andrew R Green, Paul Timpson, Julia M W Gee, Ian O Ellis, Susan J Clark, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt
Externí odkaz:
https://doaj.org/article/eb537bc34b10404fbde06ea888ba833f
Autor:
Shu Ly Lim, Zhi Peng Qu, R Daniel Kortschak, David M Lawrence, Joel Geoghegan, Anna-Lena Hempfling, Martin Bergmann, Christopher C Goodnow, Christopher J Ormandy, Lee Wong, Jeff Mann, Hamish S Scott, Duangporn Jamsai, David L Adelson, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005782 (2015)
Externí odkaz:
https://doaj.org/article/8d893ef0cd6a4757964e622bdb13063f
Autor:
Shu Ly Lim, Zhi Peng Qu, R Daniel Kortschak, David M Lawrence, Joel Geoghegan, Anna-Lena Hempfling, Martin Bergmann, Christopher C Goodnow, Christopher J Ormandy, Lee Wong, Jeff Mann, Hamish S Scott, Duangporn Jamsai, David L Adelson, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005620 (2015)
piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of piRNA methylation is poorly defined in mammals. Usi
Externí odkaz:
https://doaj.org/article/696a274f282f4f478e57fd44243324b3
LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.
Autor:
Yan Liu, Kathleen DeBoer, David M de Kretser, Liza O'Donnell, Anne E O'Connor, D Jo Merriner, Hidenobu Okuda, Belinda Whittle, David A Jans, Athina Efthymiadis, Robert I McLachlan, Christopher J Ormandy, Chris C Goodnow, Duangporn Jamsai, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005090 (2015)
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OA
Externí odkaz:
https://doaj.org/article/040121e1c3374ed8a427d065623bd48c
Autor:
Moira K O'Bryan, Brett J Clark, Eileen A McLaughlin, Rebecca J D'Sylva, Liza O'Donnell, Jacqueline A Wilce, Jessie Sutherland, Anne E O'Connor, Belinda Whittle, Christopher C Goodnow, Christopher J Ormandy, Duangporn Jamsai
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003628 (2013)
Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation
Externí odkaz:
https://doaj.org/article/5e823f89f3ff43c5a2abffb7ec30fb03
Autor:
Duangporn Jamsai, Brett J Clark, Stephanie J Smith, Belinda Whittle, Christopher C Goodnow, Christopher J Ormandy, Moira K O'Bryan
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77311 (2013)
ETV5 (Ets variant gene 5) is a transcription factor that is required for fertility. In this study, we demonstrate that ETV5 plays additional roles in embryonic and postnatal developmental processes in the mouse. Through a genome-wide mouse mutagenesi
Externí odkaz:
https://doaj.org/article/af678d0fd4c74217b9323efeea6a6902
Autor:
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia M W Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibilit
Externí odkaz:
https://doaj.org/article/7e94d3be63174fc88be2581b9f7d3521
Autor:
Jennifer C Y Lo, Duangporn Jamsai, Anne E O'Connor, Claire Borg, Brett J Clark, James C Whisstock, Mark C Field, Vicki Adams, Tomomoto Ishikawa, R John Aitken, Belinda Whittle, Christopher C Goodnow, Christopher J Ormandy, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002969 (2012)
A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia. C
Externí odkaz:
https://doaj.org/article/0a77d3c55a5a43aba77dfcbf7ca1d93d