Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Christopher J Ong"'
Autor:
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 219-238 (2018)
Abstract Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathway
Externí odkaz:
https://doaj.org/article/2f44866b8d6c48509b92457ef60f92f1
Autor:
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevale
Externí odkaz:
https://doaj.org/article/04472dd65cc24c0c8a00dc7c0f4fd55c
Autor:
Peter T W Kim, Brad G Hoffman, Annette Plesner, Cheryl D Helgason, C Bruce Verchere, Stephen W Chung, Garth L Warnock, Alice L F Mui, Christopher J Ong
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14146 (2010)
Pluripotent embryonic stem cells hold a great promise as an unlimited source of tissue for treatment of chronic diseases such as Type 1 diabetes. Herein, we describe a protocol using all-trans-retinoic acid, basic fibroblast growth factor and dibutyr
Externí odkaz:
https://doaj.org/article/7d56353c45af4bfab4d144d96218cca8
Autor:
Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong
Publikováno v:
Cells, Vol 12, Iss 13, p 1715 (2023)
Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ident
Externí odkaz:
https://doaj.org/article/ce525f990ef941c8b21cdd5b891206db
Autor:
Abrar Samiea, Jeff S. J. Yoon, Christopher J. Ong, Amina Zoubeidi, Thomas C. Chamberlain, Alice L.-F. Mui
Publikováno v:
Prostate Cancer, Vol 2020 (2020)
Interleukin-10 (IL10) is best studied for its inhibitory action on immune cells and ability to suppress an antitumour immune response. But IL10 also exerts direct effects on nonimmune cells such as prostate cancer epithelial cells. Elevated serum lev
Externí odkaz:
https://doaj.org/article/bc6b7ee61bac411b9c6eba4813cc37ea
Autor:
Yuzhuo Wang, Dong Lin, Colin C. Collins, Martin E. Gleave, Housheng H. He, Amina Zoubeidi, Christopher J. Ong, Francesco Crea, Ladan Fazli, Anne M. Haegert, Fang Zhang, Peter W. Gout, Sifeng Qu, Rebecca Wu, Hui Xue, Stephen Y. Choi, Xin Dong, Jun Hao, Xinpei Ci
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer arising mostly from adenocarcinoma via neuroendocrine transdifferentiation following androgen deprivation therapy. Mechanisms contributing to both NEPC development and its a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f33ba9b997e9d31ab8e21602e825984
https://doi.org/10.1158/0008-5472.c.6510333
https://doi.org/10.1158/0008-5472.c.6510333
Autor:
Yuzhuo Wang, Dong Lin, Colin C. Collins, Martin E. Gleave, Housheng H. He, Amina Zoubeidi, Christopher J. Ong, Francesco Crea, Ladan Fazli, Anne M. Haegert, Fang Zhang, Peter W. Gout, Sifeng Qu, Rebecca Wu, Hui Xue, Stephen Y. Choi, Xin Dong, Jun Hao, Xinpei Ci
Supplementary materials and methods used in this study. Supplementary table with primer sequences. Figure S1, Histological feature of PDX models and heatmaps of PDX and clinical cohorts. Figure S2, IHC staining of HP1α in PDX models, and expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a50416361d81a88dcc967056579c57
https://doi.org/10.1158/0008-5472.22419258
https://doi.org/10.1158/0008-5472.22419258
Autor:
Mani Roshan-Moniri, Franck Duong, Fuqiang Ban, Hélène Morin, Huifang Li, Kush Dalal, Paul S. Rennie, Christopher J. Ong, Eric Leblanc, Michael Carlson, Kevin J. Tam, Ashley Shepherd, Artem Cherkasov, James W. Peacock, Aishwariya Sharma, Carl Perez
Publikováno v:
Cancer Letters. 437:35-43
Prostate cancer (PCa) is a leading cause of death for men in North America. The androgen receptor (AR) - a hormone inducible transcription factor - drives expression of tumor promoting genes and represents an important therapeutic target in PCa. The
Autor:
Kamaldeep Jawanda, Christopher J. Ong, Soroush Shakibakho, Filip Van Petegem, Thomas C. Chamberlain, Edis Dzananovic, Fuqiang Ban, Sylvia T. Cheung, Bernd R. Gardill, Jeff S. J. Yoon, Raymond J. Andersen, Andrew Ming-Lum, Artem Cherkasov, John J. Priatel, Sean A. McKenna, Abrar Samiea, Gerald Krystal, Alice L.-F. Mui
The anti-inflammatory actions of interleukin-10 (IL10) are thought to be mediated primarily by the STAT3 transcription factor, but pro-inflammatory cytokines such as interleukin-6 (IL6) also act through STAT3. We now report that IL10, but not IL6 sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78413ed51d0ff77ae4b6e3593eac57cc
https://doi.org/10.1101/2020.05.29.123943
https://doi.org/10.1101/2020.05.29.123943
Publikováno v:
The ProstateREFERENCES. 81(6)
Background Castration resistant prostate cancer progression is associated with an acquired intratumoral androgen synthesis. Signaling pathways that can upregulate androgen production in prostate tumor microenvironment are not entirely known. In this