Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Christopher J Lengner"'
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Publikováno v:
eLife, Vol 11 (2022)
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to
Externí odkaz:
https://doaj.org/article/5a2e0adc44d4496d8818d07ddfebb226
Autor:
Yuhua Tian, Xianghui Ma, Cong Lv, Xiaole Sheng, Xiang Li, Ran Zhao, Yongli Song, Thomas Andl, Maksim V Plikus, Jinyue Sun, Fazheng Ren, Jianwei Shuai, Christopher J Lengner, Wei Cui, Zhengquan Yu
Publikováno v:
eLife, Vol 6 (2017)
Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration and tumorigenesis can help uncover the underlying principles of intestinal homeo
Externí odkaz:
https://doaj.org/article/1d2bccaaafe9496e8e76507d170d4c34
Autor:
Ning Li, Qin Zhu, Yuhua Tian, Kyung Jin Ahn, Xin Wang, Zvi Cramer, Justine Jou, Ian W. Folkert, Pengfei Yu, Stephanie Adams-Tzivelekidis, Priyanka Sehgal, Najia N. Mahmoud, Cary B. Aarons, Robert E. Roses, Andrei Thomas-Tikhonenko, Emma E. Furth, Ben Z. Stanger, Anil Rustgi, Malay Haldar, Bryson W. Katona, Kai Tan, Christopher J. Lengner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenv
Externí odkaz:
https://doaj.org/article/27a70ad4c8a74c5881020e751a7a5388
Autor:
Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
Publikováno v:
eLife, Vol 3 (2014)
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated
Externí odkaz:
https://doaj.org/article/1bcc618553ce4884a9566906671808ea
Autor:
Ozlem Yildirim, Jui-Hung Hung, Ryan J Cedeno, Zhiping Weng, Christopher J Lengner, Oliver J Rando
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004515 (2014)
Dynamic exchange of a subset of nucleosomes in vivo plays important roles in epigenetic inheritance of chromatin states, chromatin insulator function, chromosome folding, and the maintenance of the pluripotent state of embryonic stem cells. Here, we
Externí odkaz:
https://doaj.org/article/1b6ec453cb6040e98a013ba86c79d207
Autor:
Young-Jun Choi, Melissa S. Kim, Joshua H. Rhoades, Nicolette M. Johnson, Corbett T. Berry, Sarah Root, Qijun Chen, Yuhua Tian, Rafael J. Fernandez, III, Zvi Cramer, Stephanie Adams-Tzivelekidis, Ning Li, F. Brad Johnson, Christopher J. Lengner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 451-472 (2023)
Background & Aims: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction experience multiorgan failure. In
Externí odkaz:
https://doaj.org/article/097aee7b209740a1bf70038743eb0b74
Autor:
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial
Externí odkaz:
https://doaj.org/article/4cc16e72c1d5417fbecfca91adb61af1
Autor:
Xiaolei Liu, William D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga, Kristin Lorent, Alexander J. Valvezan, Rebecca L. Myers, Ning Li, Christopher J. Lengner, Yoseph Barash, Michael Pack, Peter S. Klein
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 3, p 29 (2023)
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understandin
Externí odkaz:
https://doaj.org/article/f1611d5c12b54d1ba12ab6eacd305385
Autor:
Klein, Xiaolei Liu, William D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga, Kristin Lorent, Alexander J. Valvezan, Rebecca L. Myers, Ning Li, Christopher J. Lengner, Yoseph Barash, Michael Pack, Peter S.
Publikováno v:
Journal of Developmental Biology; Volume 11; Issue 3; Pages: 29
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understandin
Autor:
Ajeya Nandi, Rahul Debnath, Anupma Nayak, Tsun Ki Jerrick To, Gatha Thacker, Megan Reilly, Sanjeev Gumber, Ilias Karagounis, Ning Li, Christopher J. Lengner, Malay Haldar, Alana L. Welm, Andres M. Blanco, Christoforos Thomas, Rumela Chakrabarti
Publikováno v:
Cancer Res
Resistance to radiotherapy is a major obstacle for effective cancer treatment. Both cancer-associated fibroblasts (CAF) within the tumor microenvironment (TME) and Notch signaling are implicated in radioresistance, but their potential interrelationsh