Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Christopher J Heath"'
Autor:
Ella Waters, Perla Pucci, Ruman Rahman, Anna P Yatsyshyna, Harry Porter, Mark Hirst, Radka Gromnicova, Igor Kraev, Vera Mongiardini, Benedetto Grimaldi, Jon Golding, Helen L Fillmore, Balázs Győrffy, Priyadarsini Gangadharannambiar, Christos N Velanis, Christopher J Heath, Francesco Crea
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312237 (2024)
The long non-coding RNA (lncRNA), HAR1A is emerging as a putative tumour suppressor. In non-neoplastic brain cells, REST suppresses HAR1A expression. In gliomas REST acts as an oncogene and is a potential therapeutic target. It is therefore conceivab
Externí odkaz:
https://doaj.org/article/c9807a1bb67247c59c737f1393640411
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
Autor:
So Yeon Cho, Eun Woo Kim, Soo Jin Park, Benjamin U. Phillips, Jihyeon Jeong, Hyunjeong Kim, Christopher J. Heath, Daehwan Kim, Yurim Jang, Laura López-Cruz, Lisa M. Saksida, Timothy J. Bussey, Do Yup Lee, Eosu Kim
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer’s disease (AD), also known as “type 3 diabetes”. Nevertheless, some studies have demonstrated that metformin may trigger AD pathology
Externí odkaz:
https://doaj.org/article/fb57a506ec6e4434861058289b715df9
Autor:
Cheryl A. Hawkes, Christopher J. Heath, Matthew M. Sharp, Dariusz C. Górecki, Roxana O. Carare
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract α-Dystrobrevin (α-DB) is a major component of the dystrophin-associated protein complex (DAPC). Knockout (KO) of α-DB in the brain is associated with astrocytic abnormalities and loss of neuronal GABA receptor clustering. Mutations in DAP
Externí odkaz:
https://doaj.org/article/306a2ece7fcb4cad83f65ebbf1a9a1e1
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
The COVID-19 pandemic led to the introduction of a range of infection prevention and control (IPC) measures that resulted in dramatic changes in people's lives however these IPC measures are not practiced consistently across the population. One predi
Externí odkaz:
https://doaj.org/article/48cb73afe82a4fb3aaad80fc30d6f12c
Autor:
Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath, Chul Hoon Kim
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful
Externí odkaz:
https://doaj.org/article/17f58c3c082c4681a072d3458b175a73
Autor:
Eun Woo Kim, Benjamin U. Phillips, Christopher J. Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J. Bussey, Chul Hoon Kim, Eosu Kim, Lisa M. Saksida
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal stan
Externí odkaz:
https://doaj.org/article/043513ee44e341bca0a70b93ab0796c9
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Compelling experimental and clinical evidence supports a role for maternal obesity in offspring health. Adult children of obese mothers are at greater risk of obesity, diabetes, coronary heart disease and stroke. These offspring may also be at greate
Externí odkaz:
https://doaj.org/article/ff598a9e24a44aab8cdab891fa00ac1e
Autor:
Christopher J. Heath, Claire O'Callaghan, Sarah L. Mason, Benjamin U. Phillips, Lisa M. Saksida, Trevor W. Robbins, Roger A. Barker, Timothy J. Bussey, Barbara J. Sahakian
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation o
Externí odkaz:
https://doaj.org/article/ae37506d2123462dbd8a8a78b1519506
Autor:
Laura López-Cruz, Christopher J. Heath
Motivation and motivated behaviors are crucial to the survival of living organisms. In the clinical context, inappropriate elevations or decrements in motivation are associated with a variety of adverse indications, ranging from addiction to illicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b9ae50f8a9344a5bab5f46d13cbec7
https://doi.org/10.1016/b978-0-12-809324-5.23956-4
https://doi.org/10.1016/b978-0-12-809324-5.23956-4
Publikováno v:
Nutrients; Volume 14; Issue 23; Pages: 5161
Alterations in neural pathways that regulate appetitive motivation may contribute to increased obesity risk in offspring born to mothers fed a high fat (HF) diet. However, current findings on the impact of maternal obesity on motivation in offspring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6881d5b380020d50b4e52b411acbe7
https://doi.org/10.3390/nu14235161
https://doi.org/10.3390/nu14235161