Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christopher J Eden"'
Autor:
Ashley Hagan, Christopher J. Eden, Alycia C.R. Lackey, Jacqueline M. Doyle, Michael P. Moore, Morgan Geile, Nicole Gerlanc, Howard H. Whiteman
Publikováno v:
The American Naturalist. 194:230-245
Polyphenisms-alternative morphs produced through plasticity-can reveal the evolutionary and ecological processes that initiate and maintain diversity within populations. We examined lifetime fitness consequences of two morphs in a polyphenic populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea74806a98a446b8935d6958e22efab7
https://doi.org/10.1086/704156
https://doi.org/10.1086/704156
Autor:
David Finkelstein, Kirti Gupta, Nidal Boulos, Tanya A. Kranenburg, Geoffrey Neale, Elsie White, Scott R. Olsen, Richard J. Gilbertson, Arzu Onar Thomas, Radhika Thiruvenkatam, Christopher J. Eden, Yong-Dong Wang, Jason Dapper, Birgit Nimmervoll, David S. Currle, David W. Ellison, Karen Wright, Kumarasamypet M. Mohankumar, Michele Connelly
Publikováno v:
Nature genetics
Cancers are characterized by non-random chromosome copy number alterations that presumably contain oncogenes and tumor-suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72944b79bf99c7978e7a185edf54fd3b
https://doi.org/10.1038/ng.3323
https://doi.org/10.1038/ng.3323
Autor:
Yiai Tong, David Finkelstein, Bensheng Ju, Jason Dapper, Richard J. Gilbertson, Nidal Boulos, Michael R. Taylor, Radhika Thiruvenkatam, Christopher J. Eden, Birgit Nimmervoll, Charles A. Lessman, Mohankumar Murugesan, Timothy N. Phoenix, Karen Wright, David W. Ellison
Publikováno v:
Oncogene
High-throughput screens (HTS) of compound toxicity against cancer cells can identify thousands of potential new drug-leads. But only limited numbers of these compounds can progress to expensive and labor intensive efficacy studies in mice, creating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a64bc464459eaafa51b1a2a14db48b3
http://europepmc.org/articles/PMC4205223
http://europepmc.org/articles/PMC4205223
Autor:
Waldemar Priebe, Anang A. Shelat, Paul Gibson, Dimpy Koul, Liqin Zhu, Angel M. Carcaboso, Clementine Feau, R. Kiplin Guy, Robert A. Johnson, Christopher J. Eden, Nidal Boulos, Amar Gajjar, Karen Wright, Yiai Tong, Kumarasamypet M. Mohankumar, Tanya A. Kranenburg, W. K. Alfred Yung, Leggy A. Arnold, Timothy N. Phoenix, Clinton F. Stewart, Richard J. Gilbertson, David W. Ellison, Jennifer M. Atkinson, Helen Poppleton
Publikováno v:
Cancer Cell. 20:384-399
Summary Using a mouse model of ependymoma—a chemoresistant brain tumor—we combined multicell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy studies, to identify potential treatments with predicted toxicity again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f5c351904eec4afd7c1247f7a9296e
https://doi.org/10.1016/j.ccr.2011.08.013
https://doi.org/10.1016/j.ccr.2011.08.013
Publikováno v:
Copeia. 2007:471-477
Skeletochronology is the most commonly used tool for evaluating the age of amphibians and reptiles. However, the accuracy of skeletochronology is questionable because few studies have utilized individuals of known age to calibrate their results. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad98e4cd39cfd60644c168beab6c1c7c
https://doi.org/10.1643/0045-8511(2007)7[471:aaosit]2.0.co
https://doi.org/10.1643/0045-8511(2007)7[471:aaosit]2.0.co
Autor:
Hannah E. Henson, Bensheng Ju, Wenbiao Chen, Sujuan Jia, Brent A. Orr, Michael R. Taylor, Jan M. Spitsbergen, Christopher J. Eden
Publikováno v:
Molecular Cancer
Background Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eefeb9e239ccb576590619fd3a6cb8f
https://doi.org/10.1186/s12943-015-0288-2
https://doi.org/10.1186/s12943-015-0288-2
Autor:
Yancey Gillespie, Richard Grundy, Robert A. Johnson, Richard J. Gilbertson, Jennifer M. Atkinson, Elsie White, David Finkelstein, Stephen C. Mack, Thomas E. Merchant, Christopher J. Eden, Robert A. Sanford, F.A. Boop, Kumarasamypet M. Mohankumar, Mariko DeWire, Tanya A. Kranenburg, Michael D. Taylor, Vikki Rand, Sarah Leary, David W. Ellison, Beth Coyle, Geoffrey Neale, Karen Wright, Twala L. Hogg, Paul A. Northcott, Yong Dong Wang, Amar Gajjar, Stanley Pounds, Jeffrey C. Allen, Helen Poppleton
Publikováno v:
Nature
Understanding the biology that underlies histologically similar but molecularly distinct subgroups of cancer has proven difficult because their defining genetic alterations are often numerous, and the cellular origins of most cancers remain unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c140edb1c4c7ab03b572c3bcbeed0ca9
https://pubmed.ncbi.nlm.nih.gov/20639864
https://pubmed.ncbi.nlm.nih.gov/20639864
Autor:
Christopher J Eden, Susan Magdaleno, Shannon M Norland, Diana M Batten, Tom Curran, Patricia Jensen, Tommie Cornelius, Dennis S. Rice, Nilesh Dosooye, Andrew Asbury, Karen M. Lehman, Sundeep Shakya, Anna Seal, Perdeep Mehta, Tony Cheung, Craig L. Brumwell
Publikováno v:
PLoS Biology, Vol 4, Iss 4, p e86 (2006)
PLoS Biology
PLoS Biology
This article describes an open-access gene expression database analyzed for more than 2,000 genes on mouse nervous system tissue in the coronal, sagittal, and transverse orientation representing multiple developmental ages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c564d06ea8da7a469987c00844018fa2
https://doaj.org/article/9b7ec956c92f4a0898a4a4322db9c2e1
https://doaj.org/article/9b7ec956c92f4a0898a4a4322db9c2e1
Autor:
Angel M. Carcaboso, Paul Gibson, R. Kip Guy, Robert A. Johnson, Clinton F. Stewart, Helen Poppleton, Yiai Tong, Tanya A. Kranenburg, Jennifer M. Atkinson, Anang A. Shelat, Kumarasamypet M. Mohankumar, Alexander Arnold, Karen Wright, Liqin Zhu, Timothy N. Phoenix, Amar Gajjar, Christopher J. Eden, Richard J. Gilbertson
Publikováno v:
Cancer Research. 71:4759-4759
Ependymomas are rare brain tumors that are incurable unless completely excised. The low incidence of the disease and lack of pre-clinical models has limited research efforts to advance understanding of biology and treatment. Recently, we used intersp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb62855df3f7ee4c1e5461d2a772544a
https://doi.org/10.1158/1538-7445.am2011-4759
https://doi.org/10.1158/1538-7445.am2011-4759
Autor:
Steven C. Clifford, Stanley Pounds, Yiai Tong, David Finkelstein, Helen Poppleton, Richard J. Gilbertson, Amar Gajjar, Paul Gibson, Robert J. Wechsler-Reya, Frederique Zindy, Frederic A. Boop, Janet C. Lindsey, Christopher J. Eden, Robert J. Ogg, Yanxin Pei, Zoltan Patay, David S. Currle, David W. Ellison, David H. Gutmann, Margaret C. Thompson, Matthew A. Scoggins, Giles W. Robinson, Twala L. Hogg, Martine F. Roussel, Peter J. McKinnon, Youngsoo Lee
Publikováno v:
Cancer Research. 71:3448-3448
Medulloblastoma encompasses a collection of clinically and molecularly diverse tumor subtypes that together comprise the most common malignant childhood brain tumor. These tumors are thought to arise within the cerebellum, with approximately 25% orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583874823c1e8f86a9b07326280a5dd2
https://doi.org/10.1158/1538-7445.am2011-3448
https://doi.org/10.1158/1538-7445.am2011-3448